D&C 적색 NO. 9

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

3.0 [mg/m3]

130 [mg/m3]

790 [mg/m3]

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. [http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=5160-02-1]

D & C Red No. 9

Group 3: Not classifiable as to its carcinogenicity to humans

Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

1993

1992

D & C Red No. 9

...5 MALE & 5 FEMALE OSBORNE-MENDEL RATS WERE FED 2500, 5000, 10,000 OR 20,000 MG D & C RED NO 9 PER KG OF DIET FOR 20 WK. SPLENOMEGALY OCCURRED IN ALL TREATED RATS.

...25 MALE & 25 FEMALE OSBORNE-MENDEL RATS WERE FED 0 (CONTROL), 100, 500, 2500 OR 10,000 MG.../KG OF DIET. ...RATS DEVELOPING TUMORS IN RESPECTIVE GROUPS...22/50 (CONTROLS), 19/50, 23/50, 27/50 & 21/50. ... TUMORS NOT OCCURRING IN CONTROL...INCL FIBROSARCOMAS...EPIDERMOID CARCINOMAS...INTERSTITIAL-CELL ADENOMA OF TESTIS...

Groups of 25 male and 25 female Osborne-Mendel rats, three weeks of age, were fed 1, 100, 500, 2500, or 10,000 mg/kg of diet (ppm) D&C Red No. 9 (purity, greater than or equal 86% (impurities unspecified)) for up to 103-108 weeks, when all surviving animals were killed. About 80% of rats in all groups survived 18 months or longer. There was no significant increase in the incidence of tumors at any sites.

Groups of 50 male and 50 female ICR (Swiss Webster-derived) mice (age unspecified) received topical application of 1 mg D&C Red No. 9 (90.0% pure (impurities unspecified)) in 0.1 ml water to an area of approximately 6 cm sq of clipped back skin, twice a week for 18 months. Three groups of 50 male and 50 female controls received applications of water alone. No differences in survival was observed at 18 months. No skin tumor was found. Although various tumors developed in the mammary glands and internal organ, no treatment-related difference in incidence was found.

For more Non-Human Toxicity Excerpts (Complete) data for C.I. PIGMENT RED 53:1 (9 total), please visit the HSDB record page.

Evaluation: There is inadequate evidence in humans for the carcinogenicity of D&C Red No. 9. There is limited evidence in experimental animals for the carcinogenicity of D&C Red No. 9. Overall evaluation: D&C Red No. 9 is not classifiable as to its carcinogenicity to humans (Group 3).

A carcinogenesis bioassay of D&C Red No. 9 ... was conducted by feeding diets containing 1,000 or 3,000 ppm of the test substance (89.8% pure) to groups of 50 F344 rats of either sex for 103 wk. Similar groups of 50 B6C3F1 mice received diets containing 1,000 or 2,000 ppm of the test substance for 103 wk. Groups of 50 untreated rats and mice of either sex served as controls. ... Under the conditions of this bioassay, D&C Red No. 9 was carcinogenic in male F344 rats causing an incr incidence of sarcomas of the spleen and a dose related incr in neoplastic nodules of the liver. D&C Red No. 9 was not considered carcinogenic to female F344 rats, although the incr incidence of neoplastic nodules of the liver may have been associated with the administration of the test chemical. D&C Red No. 9 was not carcinogenic in B6C3F1 mice of either sex. Levels of Evidence of Carcinogenicity: Male Rats: Positive; Female Rats: Equivocal; Male Mice: Negative; Female Mice: Negative.

1.5e-06

CALEPA

0.0053

CALEPA