기본 정보
- CAS
85320-68-9- 표준 SMILES
COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1- InChIKey
LVEXHFZHOIWIIP-UHFFFAOYSA-N- 분자식
- C18H24N2O5S
- 평균 분자량
- 380.5 g/mol
- 단동위원소 질량
- 380.14059304
개요
Amosulalol is a sulfonamide.
이름 및 식별자
- 우선 이름
- Amosulalol
- IUPAC
- 5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamide
- 영어명
- Amosulalol
- 분자식
- C18H24N2O5S
- 분자량
- 380.46
이름 및 동의어
Amosulalol85320-68-9AmosulalolumC69JI1BAU8DTXSID908688935-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamide5-[1-Hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methylbenzenesulfonamideRefChem:112259DTXCID50816951Amosulalol [INN]5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamideAmosulalol (INN)
이름 더 보기
Amosulalol USP/EP/BPAmosulalol, 10 mM in DMSOBenzenesulfonamide, 5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-Benzenesulfonamide, 5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-, (+-)-
(+-)-5-(1-Hydroxy-2-((2-(o-methoxyphenoxy)ethyl)amino)ethyl)-o-toluenesulfonamideAmosulalolum [Latin]UNII-C69JI1BAU8AMOSULALOL [MI]5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methyl-benzenesulfonamideAMOSULALOL [WHO-DD]SCHEMBL48933CHEMBL152231
데이터베이스 식별자
- CAS
85320-68-9
물성
구조 계산 물성
- XLogP
- 1.2
- 극성 표면적
- 119 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 9
- 무거운 원자 수
- 26
- 형식 전하
- 0
- 복잡도
- 510
물리화학적 성질
- 물리적 상태
- Solid
- 색상
- White to off-white
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
응용 분야
개요Amosulalol is a potent antihypertensive with combined alpha and beta blocking properties. Indicated for the treatment of essential hypertension, it appears to possess a minimum of side-effects. Its beta-blocking property reduces the tachycardia associated with alpha-blockers, while its alpha-blocking activity reduces the peripheral vasoconstriction associated with beta-blockade.
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