암피록시캠
암피록시캠 · Nasil · Flucam · CP 65703 · Ampiroam · AMPIROXICAM · Ampiroxicam 98% · Ampiroxicam(CP 65703)
식별자 및 물리적 특성
| CAS No. | 99464-64-9 |
|---|---|
| 분자식 | C20H21N3O7S |
| 평균 분자량 | 447.5 g/mol |
| 단동위원소 질량 | 447.11002119 g/mol |
| SMILES | CCOC(=O)OC(C)OC1=C(C(=O)Nc2ccccn2)N(C)S(=O)(=O)c2ccccc21 |
| InChIKey | LSNWBKACGXCGAJ-UHFFFAOYSA-N |
| PubChem CID | 2176 |
| ChEMBL | CHEMBL1566249 |
| ChEBI | CHEBI:31210 |
| EC No. | 807-877-6 |
| DTXSID | DTXSID6046474 |
| 현지명 | 암피록시캠 |
화학 및 물리적 성질
| XLogP | 4 |
|---|---|
| 극성 표면적 | 133 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 9 |
| 회전 가능 결합 수 | 8 |
| 무거운 원자 수 | 31 |
| 형식 전하 | 0 |
| 복잡도 | 808 |
| 녹는점 | 159-161C |
| 밀도 | 1.44±0.1 g/cm3(Predicted) |
| 저장 조건 | Sealed in dry,2-8°C |
| 용해도 | 클로로포름(약간 용해됨), 메탄올(약간 용해됨) |
| 물리적 상태 | 고체 |
| pKa(산도 계수) | 12.74±0.20(Predicted) |
| 색상 | 흰색에서 황백색까지 |
화학적 성질
White Solid
안전 및 규제
| GHS 분류 | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory. |
|---|---|
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Drug Induced Liver Injury | Drug-Induced Liver Injury Severity and Toxicity (DILIst)AmpiroxicamDILI PositiveDOI:10.1016/j.drudis.2019.09.022 |
| 독성 | LD50 orally in male, female rats: 1798, 747 mg/kg (Iijima) |
용도
개요
Ampiroxicam is a once-daily non-steroidal anti-inflammatory drug (NSAID) introduced in Japan. As a non-acidic ether carbonate prodrug of the widely used antiinflammatory agent, piroxicam, ampiroxicam is similar or more potent than piroxicam in suppressing carrageenan edema, ultraviolet erythema, traumatic edema, capillary permeability, acetic acid writhing, yeast algesia and yeast hyperthermia in many animals. Eioavailability studies in man show undetectable plasma levels of ampiroxicam indicating 100% conversion to piroxicam during absorption process. Ampiroxicam has been reported to have fewer side effects on the gastric mucosa than piroxicam.
용도
Prodrug of Piroxicam. Anti-inflammatory.