CAS 141625-93-6 Dronedarone Hydrochloride (HCID 219025)

개요

Dronedarone Hydrochloride is the hydrochloride salt form of dronedarone, an orally bioavailable benzofuran derivative, with anti-arrhythmic activity. Upon oral administration, and although the exact mechanism of action through which dronedarone exerts its anti-arrhythmic effect has not been fully elucidated, it inhibits multiple voltage-gated ion channels, including sodium, potassium, and calcium ion channels, and restores the normal sinus rhythm and reduces heart rate in atrial fibrillation. It also non-competitively antagonizes adrenergic receptors.

이름 및 식별자

우선 이름: Dronedarone Hydrochloride
IUPAC: N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide;hydrochloride
영어명: Dronedarone hydrochloride
분자식: C31H44N2O5S.ClH
분자량: 593.22

이름 및 동의어

Dronedarone hydrochloride141625-93-6Dronedarone HClSR33598BUNII-FA36DV299QFA36DV299QN-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide monohydrochlorideDTXSID30161779DRONEDARONE HYDROCHLORIDE [EP MONOGRAPH]N-(2-Butyl-3-(4-(3-(dibutylamino)proproxy)benzoyl)benzofuran-5-yl) methanesulfonamide-, monohydrochlorideDRONEDARONE HYDROCHLORIDE (MART.)DRONEDARONE HYDROCHLORIDE [MART.]

이름 더 보기

Dronedarone hydrochloride, ≥98% (HPLC)MultaqCS-132SR33589SR-33589BCAS:141625-93-6DRONEDARONE HCl CAS:Multaq Hydrochloride.SR33589 Hydrochloride

DRONEDARONE HYDROCHLORIDE (USP-RS)DRONEDARONE HYDROCHLORIDE [USP-RS]Methanesulfonamide, N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-, monohydrochlorideDRONEDARONE HYDROCHLORIDE (EP MONOGRAPH)DRONEDARONE HYDROCHLORIDE (USP MONOGRAPH)DRONEDARONE HYDROCHLORIDE [USP MONOGRAPH]Methanesulfonamide, N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-, monohydrochlorideRefChem:55074

데이터베이스 식별자

CAS: 141625-93-6
PubChem CID: 219025
DTXSID: DTXSID30161779
ChEMBL: CHEMBL1201729
UNII: FA36DV299Q
EC Number: 630-355-2

물성

구조 계산 물성

극성 표면적: 97.2 Å²
수소 결합 공여자 수: 2
수소 결합 수용자 수: 7
회전 가능 결합 수: 18
무거운 원자 수: 40
형식 전하: 0
복잡도: 800

실험 및 물리화학적 성질

Human Drugs · 2건

FDA approved drugs -> Active ingredient

물리화학적 성질

녹는점: NA (low-melting)
저장 조건: 2 · 2-8°C
용해도: 15 mg/mL, · DMSO: 용해성15mg/mL, 투명
물리적 상태: 가루
색상: 흰색에서 황백색까지
Merck: 14 · 14,3449
안정성: 흡습성
InChIKey: DWKVCQXJYURSIQ-UHFFFAOYSA-N
SMILES: Cl.CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c2c(CCCC)oc3ccc(NS(C)(=O)=O)cc23

화학적 성질

Pale Yellow Solid

안전 및 규제

GHS 분류

GHS Classification · 5건

This chemical does not meet GHS hazard criteria for 8.3% (1 of 12) of reports.

Warning

H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P260, P261, P263, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 12 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 4 (33.3%)

독성 정보

Drug Induced Liver Injury · 6건

Drug Induced Liver Injury Rank (DILIrank 2.0)

Dronedarone hydrochloride

vMost-DILI-concern

7

Warnings & precautions

DOI:10.1016/j.drudis.2016.02.015

안전 데이터

wgk: 3
ridadr: UN 3077 9 / PGIII
HS 번호: 2935904000
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

응용 분야 · 2건

역사DRONEDARONE HYDROCHLORIDE (brand name: Multaq) is an antiarrhythmic drug developed by Sanofi-Aventis. It was approved by the FDA in July 2009 for the treatment of atrial fibrillation and atrial flutter, reducing the risk of cardiovascular hospitalization in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL). The drug was developed to create a treatment that maintains the therapeutic benefits of amiodarone while reducing associated serious side effects such as pulmonary toxicity and thyroid dysfunction. DRONEDARONE HYDROCHLORIDE is usually administered orally in tablet form. The recommended dose is 400 mg twice daily, one tablet in the morning and one in the evening.

용도Dronedarone Hydrochloride can be used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.