기본 정보
- CAS
5714-73-8- 표준 SMILES
C1N2CN3CN1CN(C2)C3.O=C(O)CNC(=O)c1ccccc1- InChIKey
ROAIXOJGRFKICW-UHFFFAOYSA-N- 분자식
- C15H21N5O3
- 평균 분자량
- 319.36 g/mol
- 단동위원소 질량
- 319.16443955
개요
Methenamine hippurate is a N-acylglycine. It is functionally related to a N-benzoylglycine.
이름 및 식별자
- 우선 이름
- Methenamine Hippurate
- IUPAC
- 2-benzamidoacetic acid;1,3,5,7-tetrazatricyclo[3.3.1.13,7]decane
- 영어명
- Methenamine hippurate
- 분자식
- C15H21N5O3
- 분자량
- 319.37
이름 및 동의어
Methenamine hippurate5714-73-8Viaptahexamine hippurateHippramineHexamethylene tetramine hippurateM329791L57Hip-RexRefChem:55599Glycine, N-benzoyl, compound with 1,3,5,7-tetraazatricyclo(3.3.1.1(sup 3,7))decane(1:1)UrexHiprex
이름 더 보기
Methenamine Hippuric acidr-657Urex (tn)cane(1:1)Hiprex (tn)
Hexamethylenetetramine monohippurate1,3,5,7-tetraazaadamantane benzoylglycinateMethenamine (hippurate)2-benzamidoacetic acid;1,3,5,7-tetrazatricyclo[3.3.1.13,7]decaneHaiprexD00855Hexamethylenetetramine hippurate1,3,5,7-Tetraazatricyclo[3.3.1.13,7]decane, compd. with N-benzoylglycine (1:1)
데이터베이스 식별자
- CAS
5714-73-8- PubChem CID
- 21945
- DTXSID
DTXSID10972603- ChEMBL
CHEMBL1201104- ChEBI
CHEBI:6825- UNII
- M329791L57
- EC Number
- 227-206-5
물성
구조 계산 물성
- 극성 표면적
- 79.4 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 23
- 형식 전하
- 0
- 복잡도
- 282
실험 및 물리화학적 성질
Human Drugs
Breast Feeding; Lactation; Anti-Infective Agents, Urinary
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 89 · 89-95°C
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
- 수용성
- 2 O: · H2O: 2mg/mL, clear
- InChI
- 1S/C9H9NO3.C6H12N4/c11-8(12)6-10-9(13)7-4-2-1-3-5-7;1-7-2-9-4-8(1)5-10(3-7)6-9/h1-5H,6H2,(H,10,13)(H,11,12);1-6H2
- InChIKey
- ROAIXOJGRFKICW-UHFFFAOYSA-N
- SMILES
- OC(CNC(C1=CC=CC=C1)=O)=O.N2(CN(C3)C4)CN3CN4C2
화학적 성질
White Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H315 (33.3%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P272, P280, P302+P352, P305+P351+P338, P321, P332+P317, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 3 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesSkin Irrit. 2 (33.3%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Methenamine hippurate
Ambiguous-DILI-concern
3
Warnings & precautions
DOI:10.1016/j.drudis.2016.02.015
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
안전 데이터
- wgk
- WGK 3
- HS 번호
- 2933690000
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Substances capable of killing agents causing urinary tract infections or of preventing them from spreading.
Substances that inhibit the growth or reproduction of BACTERIA.
응용 분야
개요Methenamine hippurate is a broad-spectrum urinary antiseptic agent. Under acidic conditions, methenamine hippurate is hydrolyzed to formaldehyde and ammonia, which exerts an antibacterial effect. It is effective against a wide range of bacteria but lacks activity against Proteus and other bacteria that increase urine alkalinity. Formulations containing methenamine hippurate have been used to treat urinary tract infections.
용도Antibacterial (urinary).
일반 설명Methenamine hippurate (Hiprex) is the hippuric acid salt ofmethenamine. It is readily absorbed after oral administrationand is concentrated in the urinary bladder, where it exerts itsantibacterial activity. Its activity is increased in acid urine.
상·하류 제품 정보
상류 원료
공급사60 곳
国药集团化学试剂有限公司86-21-63210123 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
艾吉析科技（上海）有限公司
관련 반응
0건
현재 필터 조건에 해당하는 반응 기록이 없습니다.
화합물 노트
불러오는 중…