기본 정보
- CAS
127-27-5- 표준 SMILES
C=C[C@@]1(C)C=C2CC[C@@H]3[C@](C)(CCC[C@@]3(C)C(=O)O)[C@H]2CC1- InChIKey
MHVJRKBZMUDEEV-APQLOABGSA-N- 분자식
- C20H30O2
- 평균 분자량
- 302.5 g/mol
- 단동위원소 질량
- 302.2245802
개요
(+)-Pimaric acid is a diterpenoid.
이름 및 식별자
- 우선 이름
- Pimaric Acid
- IUPAC
- (1R,4aR,4bS,7S,10aR)-7-ethenyl-1,4a,7-trimethyl-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid
- 영어명
- Pimaric acid
- 분자식
- C20H30O2
- 분자량
- 302.45
이름 및 동의어
PIMARIC ACID127-27-5Dextropimaric acidd-Pimaric acidUsic acidalpha-Pimaric acidPimaradienoic acidPimara-8(14),15-dien-19-oic acid88R98Z71NINSC-2956(1R,4aR,4bS,7S,10aR)-7-ethenyl-1,4a,7-trimethyl-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid(1R,4aR,4bS,7S,10aR)-1,4a,7-trimethyl-7-vinyl-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthrene-1-carboxylic acid
이름 더 보기
PimaricNSC 2956Pimaric Acid (>Δ8(14)-PiMaric AcidPimaric acid (PiMA)Pimaric Acid (> 75%)Hexazinone Impurity 278(14),15-PiMaradien-18-oic Acid
RefChem:8632881-Phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-, (1R-(1alpha,4abeta,4balpha,7beta,10aalpha))-PIMARIC ACID, Dalpha-Pimaricacid(+)-Pimaric acid.alpha.-Pimaric acidNSC2956.delta.8(14)-Pimaric acid
데이터베이스 식별자
물성
구조 계산 물성
- XLogP
- 5.5
- 극성 표면적
- 37.3 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 2
- 무거운 원자 수
- 22
- 형식 전하
- 0
- 복잡도
- 534
실험 및 물리화학적 성질
Endocrine DisruptorsPotential endocrine disrupting compound
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
물리화학적 성질
- 녹는점
- 217 · 217-219°
- 끓는 점
- 18 · bp18 282°
- 밀도
- 1.0434 · 1.0434 (rough estimate)
- 굴절률
- 1.48 · 1.4800 (estimate)
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- DMSO: soluble,Water: soluble
- 산도 계수 (pKa)
- 4.68 · 4.68±0.60(Predicted)
- 물리적 상태
- Solid
- 색상
- White to off-white
- LogP
- 6.731 · 6.731 (est)
- EPA
- Pimaric acid (127-27-5)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Regulatory Information
Chemical: 1-Phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-, [1R-(1.alpha.,.4a.beta.,4b.alpha.,7.beta.,10a.alpha.)]-
Pimaric acid: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
화학 및 산업
응용 분야
개요Pimaric acid is a resin acid that has been found in A. cordata and various pines. It reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs) in a concentration-dependent manner when used at concentrations ranging from 5 to 20 μM. Pimaric acid (10-20 μM) reduces nuclear expression and binding of the transcription factors NF-κB and AP-1 to the MMP-9 promoter in HASMCs. Pimaric acid also reduces TNF-α-induced HASMC migration to control levels when used at a concentration of 20 μg/ml.
용도A novel activators of large-conductance Ca2+-activated K+ channel α-subunit.
상·하류 제품 정보
하류 제품
공급사49 곳
成都乐美天医药科技有限公司17308096051 17308096051 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
成都健腾生物技术有限公司028-85159085 18080455027 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
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