아프린딘

Aprindine

HCID 2218CAS 33237-74-0
부분 구조 검색유사 구조 찾기

기본 정보

표준 SMILES
CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1
InChIKey
NZLBHDRPUJLHCE-UHFFFAOYSA-N
분자식
C22H30N2
평균 분자량
322.5 g/mol
단동위원소 질량
322.24089896

개요

Aprindine is a member of indanes.

이름 및 식별자

우선 이름
Aprindine
IUPAC
N'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamine
현지명
아프린딘
영어명
Aprindine
분자식
C22H30N2
분자량
322.49

이름 및 동의어

APRINDINE37640-71-4AprindinaAprindinumCOMPOUND 99170COMPOUND-991701,3-Propanediamine, N-(2,3-dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenyl-DTXSID30226155Y48085P9Q(3-((2,3-dihydro-1H-inden-2-yl)(phenyl)amino)propyl)diethylamine{3-[(2,3-dihydro-1H-inden-2-yl)(phenyl)amino]propyl}diethylamineRefChem:388807
이름 더 보기
아프린딘AC-1802Lilly-83846Aprindine USP/EP/BP3-(diethylamino)propyl-indan-2-yl-phenyl-amineN,N'-Diethyl-N'-2-indanyl-N'-phenyl-1,3-Prop-anediaminen-(2,3-dihydro-1h-inden-2-yl)-n',n'-diethyl-n-phenyl-3-propanediaminen-(2,3-dihydro-1h-inden-2-yl)-n',n'-diethyl-n-phenyl-1,3-propanediamine
DTXCID702615AprindinAprinidineAprindinum [INN-Latin]Aprindina [INN-Spanish]FibocilN'-(2,3-dihydro-1H-inden-2-yl)-N,N-diethyl-N'-phenylpropane-1,3-diamineN,N-Diethyl-N'-2-indanyl-N'-phenyl-1,3-propanediamine

데이터베이스 식별자

CAS
33237-74-0、37640-71-4
PubChem CID
2218
DTXSID
DTXSID3022615
ChEMBL
CHEMBL1213033
ChEBI
CHEBI:135370
UNII
5Y48085P9Q
Nikkaji
J19.264C

물성

구조 계산 물성

XLogP
5.2
극성 표면적
6.5 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
2
회전 가능 결합 수
8
무거운 원자 수
24

실험 및 물리화학적 성질

DrugsPharmaceuticals -> Listed in ZINC15
LogP · 2건

4.86

4.86

Solubility7.82e-03 g/L
Human DrugsPharmaceuticals
Melting Point · 2건

120-121 °C

120 - 121 °C

Physical DescriptionSolid

물리화학적 성질

녹는점
120 · 120-121 °C
끓는 점
450.9 · 450.9±45.0 °C(Predicted)
밀도
1.046 · 1.046±0.06 g/cm3(Predicted)
산도 계수 (pKa)
4.53 · pKa 4.53 (H2O) (Uncertain);10.16(H2O) (Uncertain)
물리적 상태
Solid-Liquid Mixture
색상
Colorless to light yellow

화학 및 산업

약리 정보

ATC Code · 2건

C - Cardiovascular system

QC - Cardiovascular system

Metabolism/MetabolitesAprindine has known human metabolites that include Desethylaprindine, p-Hydroxyphenylaprindine, and N-[3-(N,NDiethylamino)propyl]-N-phenyl-2-aminoindan-5-ol.
MeSH Pharmacological Classification · 2건

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.

Cellular LocationsExtracellular

용도 및 제조

Use ClassificationPharmaceuticals

응용 분야

용도depressant (anti-arrhythmic).

상·하류 제품 정보

공급사10 곳

陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]
United Life Science020-82099279 18988941402 · [email protected]
湖北扬信医药科技有限公司0714-3999001 19171453112 · [email protected]
深圳振强药物研发有限公司+86-0755-66853366 +86-13670046396 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]

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