페니실린 G 프로카인 모노수화물

페니실린G프로카인모노수화물 · 페니실린G프로카인모노수화물(PENICILLINGPROCAINEMONOHYDRATE) · PROCAINE PENICILLIN · Penicillin G procaine salt hydrate,Benzylpenicillin procaine salt, Procaine penicilline G hydrate · D02461 · mylipen · neoproc · wycillin

https://huagongshe.com/ko/chemical/22502

식별자 및 물리적 특성

CAS No.	6130-64-9
분자식	C29H40N4O7S
평균 분자량	588.7 g/mol
단동위원소 질량	588.26177062 g/mol
SMILES	CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.CCN(CC)CCOC(=O)c1ccc(N)cc1.O
InChIKey	KZDCMKVLEYCGQX-UDPGNSCCSA-N
PubChem CID	22502
ChEMBL	CHEMBL1200936
EC No.	612-112-2
DTXSID	DTXSID40210207
현지명	페니실린 G 프로카인 모노수화물

화학 및 물리적 성질

극성 표면적	169
수소 결합 공여자 수	4
수소 결합 수용자 수	10
회전 가능 결합 수	11
무거운 원자 수	41
형식 전하	0
복잡도	752
녹는점	106-110° (with decompn)
밀도	1.255-1.256
저장 조건	Refrigerator
용해도	물에는 약간 용해되고, 에탄올에는 거의 용해되지 않습니다(96%).
물리적 상태	Solid
색상	흰색에서 황백색까지
주요 응용	의약품(소분자)
InChIKey	WHRVRSCEWKLAHX-RLWRCNEPNA-N
SMILES	C(C1C=CC(N)=CC=1)(=O)OCCN(CC)CC.C([C@H]1C(S[C@]2([H])[C@H](NC(=O)CC3C=CC=CC=3)C(=O)N12)(C)C)(=O)O \|&1:18,21,23,r\|

화학적 성질

White Solid

안전 및 규제

GHS 분류	This chemical does not meet GHS hazard criteria for 0.6% (1 of 156) of reports.DangerH317 (99.4%): May cause an allergic skin reaction [Warning Sensitization, Skin]P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 156 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
기타 안전 정보	IMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2.alpha.,5.alpha.,6.beta.)]-, compound with 2-(diethylamino)ethyl 4-aminobenzoate (1:1), monohydrate: Environment tier I assessment
Hazard Classes and Categories	Skin Sens. 1 (99.4%)
유해 작용	Many of the most harmful adverse effects of procaine penicillin occur in the setting of inadvertent intravascular administration. These include cardiac conduction disturbance and neurologic sequelae, including tonic-clonic seizure, as well as permanent neurovascular damage in the form of conditions such as transverse myelitis and gangrene requiring digital and even proximal extremity amputation. Other adverse events noted have included necrosis and sloughing at the injection site and transient psychiatric disturbance. The latter is most often observed when administering very high doses, such as 4.8 million IM units. A syndrome related to procaine known as Hoigne syndrome has been described to include confusion, combativeness, seizures, anxiety, and a sense of impending death. Hoigne syndrome symptoms last 15 to 30 minutes with resolution as the natural course. Treatment centers on symptomatic control.
수질 위해 등급(WGK)	WGK 1
RTECS 번호	XH9450000
독성	LD50 s.c. in mice: 2.3 g/kg (Soehring)
관세 코드	2941102000
위험 문구(R)	42/43
위험 표시	Xn
안전 문구(S)	36
위험 등급	Skin Sens. 1

용도

Procaine penicilline G hydrate is a composed of the β-lactam antibiotic of Penicillin G and the sodium channel blocker Procaine. As an antibiotic, Penicillin G is noted to posses effectiveness mainly against gram-positive organisms. Procaine Penicillin G is used a growth stimulant for poultry.