트윈 60
Polyoxyethylene sorbitan monostearate
기본 정보
- CAS
9005-67-8- 표준 SMILES
CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](OCCO)[C@H]1OCCO- InChIKey
CRBBOOXGHMTWOC-NPDDRXJXSA-N- 분자식
- C22H42O8
- 평균 분자량
- 434.6 g/mol
- 단동위원소 질량
- 434.28796829
개요
1,4-Anhydro-6-O-dodecanoyl-2,3-bis-O-(2-hydroxyethyl)-D-glucitol is a fatty acid ester.
이름 및 식별자
- 우선 이름
- Polyoxyethylene sorbitan monostearate
- IUPAC
- [(2R)-2-[(2R,3R,4S)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-hydroxyethyl] dodecanoate
- 현지명
- 트윈 60
- 영어명
- Tween 60
- 분자식
- C64H126O26
- 분자량
- 0
이름 및 동의어
(2R)-2-[(2R,3R,4S)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-hydroxyethyl dodecanoateDTXSID9029300Polysorbata 60(2R)-2-((2R,3R,4S)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl)-2-hydroxyethyl dodecanoateRefChem:1096504PEG-20 sorbitan palmitostearateINS-435E-435Polyoxyethylene 20 sorbitan monopalmitostearatePolyoxyethylene(20)sorbitan monopalmitostearate618-984-0CAL22UVI4M
이름 더 보기
에톡실래이티드소르비탄모노스테아레이트에톡실산화모노스테아린산소르비탄트윈60에톡실산화모노스테아린산소르비탄(ETHOXYLATEDSORBITANMONOSTEARATE)폴리솔베이트61폴리솔베이트60피이지-3솔비탄스테아레이트피이지-40솔비탄스테아레이트피이지-4솔비탄스테아레이트피이지-60솔비탄스테아레이트피이지-6솔비탄스테아레이트POLYSORBATE 60POLYOXYETHYLENE (20) SORBITAN MONOSTEARATETween 60, CPPolysorbat 60POLYOXYETHYLENE SORBITAN MONOSTEARATET-61PolysoFEMA 2916TWEEN(R) 60POLYETHYLENE GLYCOL SORBITAN MONOSTEARATE
CHEBI:53425FEMA No. 2916PEG sorbitan stearateSorbimacrogol stearate 300[(2R)-2-[(2R,3R,4S)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-hydroxyethyl] dodecanoateSorbomacrogol stearate 300Tween? 60DSSTox_CID_9300
데이터베이스 식별자
- CAS
9005-67-8、93906-96-8- PubChem CID
- 22833389
- ChEMBL
CHEMBL3184465- ChEBI
CHEBI:177394- EC Number
- 618-984-0
물성
구조 계산 물성
- XLogP
- 2.8
- 극성 표면적
- 115 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 20
- 무거운 원자 수
- 30
- 형식 전하
- 0
- 복잡도
- 420
실험 및 물리화학적 성질
PolymersOther Classes -> Polyoxyethylenes
CosmeticsCosmetic ingredients (Polysorbate 60) -> CIR (Cosmetic Ingredient Review)
FragrancesFragrance Ingredient (Polysorbate 60) -> IFRA transparency List
Food AdditivesBOILER WATER ADDITIVE, EMULSIFIER OR EMULSIFIER SALT, FLAVORING AGENT OR ADJUVANT, STABILIZER OR THICKENER, SURFACE-ACTIVE AGENT -> FDA Substance added to food
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Physical Description
Dark yellow opaque viscous liquid; [Sigma-Aldrich MSDS]
Liquid
물리화학적 성질
- 녹는점
- 23 °C · 23 °C
- 끓는 점
- 802.68 °C · 802.68°C (rough estimate)
- 밀도
- 1.1 g/cm · 1.1 g/cm 3 at 20 °C
- 증기압
- 10 hPa · <10 hPa (20 °C)
- FEMA
- 2916 · 2916 | POLYSORBATE 60
- 굴절률
- 20 · n 20/D 1.474
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Regulatory Information
Chemical: Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs.
FRI - indicates a polymeric substance containing no free-radical initiator in its Inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used.
Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs.: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
No evidence of reproductive or developmental toxicity in rats; [ToxPlanet: Shepard's Catalog of Teratogenic Agents] Causes pigmented or nucleated red blood cells and changes in erythrocyte count in 95-week constant oral studies of mice; Oral LD50 (rat) > 60 mL/kg; [RTECS] Acceptable daily intake (ADI) of 0-25 mg/kg; [JECFA] Not considered hazardous by GHS classification; [Sigma-Aldrich MSDS]
EPA Safer ChemicalChemical: Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs.
독성 정보
Toxicity Summary
The CIR Expert Panel concluded that the polysorbates listed below are safe in cosmetics when formulated to be nonirritating. This conclusion supersedes the conclusion reached in the 1984, 2000, and 2001 CIR safety assessments...Polysorbate 60...
Safe for use in cosmetics, with qualifications
안전 데이터
- wgk
- 1
- tsca
- TSCA listed
- rtecs
- WG2934000
- 독성
- LD50 orally in Rabbit: > 38000 mg/kg
- HS 번호
- 34021300
- safety_code
- 24/25
- 기존화학 물질
- KE-31688
화학 및 산업
약리 정보
Cellular LocationsMembrane
용도 및 제조
Uses
CIR ingredient: Polysorbate 60
Used as a flavoring agent, emulsifier, boiler water additive, surface-active agent, and stabilizer or thickener for foods; [FDA] Used in cosmetics, pharmaceuticals, as a lubricant and finish emulsifier for textile and leather manufacture, laboratory reagent, and flavoring; [ECHA REACH Registrations] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]
Leather Tanning and Processing [Category: Industry]
Use Classification
EPA Safer Chemical Functional Use Classes -> Surfactants
Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern
Fragrance Ingredients
Food Additives -> EMULSIFIER -> JECFA Functional Classes
Food Additives -> EMULSIFIER -> JECFA Functional Classes
General Manufacturing InformationSorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs.: ACTIVE
응용 분야
용도Tween 60 is an emulsifier manufactured by reacting stearic acid with sorbitol to yield a product which is reacted with ethylene oxide. It is a nonionic, waterdispersible surface-active agent which is very hydrophilic. It is also termed polysorbate 60. It is used in whipped vegetable toppings for overrun and lightness; in cakes for increased volume and fine grain; in icings and confectionery for lightness and syneresis control; and in salad dressing for emulsion stability. It is frequently used with sorbitan monostearate or monoand diglycerides. The typical usage range is 0.10–0.40%.
일반 설명TWEEN 60 is a niosome.
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