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베메그리드

Bemegride

HCID 2310
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
64-65-3
표준 SMILES
CCC1(C)CC(=O)NC(=O)C1
InChIKey
ORRZGUBHBVWWOP-UHFFFAOYSA-N
분자식
C8H13NO2
평균 분자량
155.19 g/mol
단동위원소 질량
155.09462866

개요

Bemegride is a white crystalline solid. Sublimes at 212 °F and 200 mm pressure. (NTP, 1992)

이름 및 식별자

우선 이름
Bemegride
IUPAC
4-ethyl-4-methylpiperidine-2,6-dione
현지명
베메그리드
영어명
3-Ethyl-3-methylglutarimide
분자식
C8H13NO2
분자량
155.19

이름 및 동의어

bemegride64-65-33-Ethyl-3-methylglutarimide4-ethyl-4-methylpiperidine-2,6-dioneMethetharimideMegibalMegimideMikedimideEukratonZentraleptinBemegridAhypnon
이름 더 보기
베메그리드베메그리드및그염류NP-13DPX6573
MalysolMegimidAntibarbiAgipnonBemegrida3-Methyl-3-ethylglutarimideBemegridumbeta-Ethyl-beta-methylglutarimide

데이터베이스 식별자

CAS
64-65-3
PubChem CID
2310
DTXSID
DTXSID0045250
ChEMBL
CHEMBL1214192
ChEBI
CHEBI:92269
UNII
57DQA39DO2
EC Number
200-588-0
Nikkaji
J1.404D

물성

구조 계산 물성

XLogP
0.7
극성 표면적
46.2 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
2
회전 가능 결합 수
1
무거운 원자 수
11
형식 전하
0
복잡도
182

실험 및 물리화학적 성질

DrugsDEA NFLIS-Drug Category -> Stimulants
Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Melting Point259 to 261 °F (NTP, 1992)
Physical DescriptionBemegride is a white crystalline solid. Sublimes at 212 °F and 200 mm pressure. (NTP, 1992)

물리화학적 성질

녹는점
126 · 126-127 °C(lit.)
끓는 점
279 °C · 279°C (rough estimate)
밀도
1.1174 · 1.1174 (rough estimate)
굴절률
1.486 · 1.4860 (estimate)
저장 조건
2 · Sealed in dry,2-8°C
수용성
물에 용해됨
용해도
31 · DMSO:31.0(Max Conc. mg/mL);199.76(Max Conc. mM)Ethanol:31.0(Max Conc. mg/mL);199.76(Max Conc. mM)
물리적 상태
가루
산도 계수 (pKa)
11.7 · pKa 11.7 (Uncertain)
색상
하얀색
Merck
14 · 14,1027

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 4건

Danger

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available. It is probably not flammable. (NTP, 1992)
Health HazardsACUTE/CHRONIC HAZARDS: When heated to decomposition it emits toxic fumes. (NTP, 1992)
Reactive GroupAmides and Imides
Reactivity Profile · 1건

BEMEGRIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Air and Water ReactionsInsoluble in water.
Hazard Classes and CategoriesAcute Tox. 2 (100%)

안전 및 보호

화학 및 산업

약리 정보

ATC Code · 2건

R - Respiratory system

QR - Respiratory system

MeSH Pharmacological Classification · 3건

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.

Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools.

Drugs used for their effects on the respiratory system.

용도 및 제조

General Manufacturing Information2,6-Piperidinedione, 4-ethyl-4-methyl-: INACTIVE

응용 분야

용도CNS stimulant;GABA antagonist

일반 설명White crystalline solid. Sublimes at 212°F and 200 mm pressure.

공급사77 곳

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上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]

관련 반응

0건
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화합물 노트

불러오는 중…

이 페이지에서기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
InChI
InChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11)
InChIKey
ORRZGUBHBVWWOP-UHFFFAOYSA-N
SMILES
N1C(=O)CC(CC)(C)CC1=O
EPA
Bemegride (64-65-3)

화학적 성질

white to off-white flakes or powder

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1건

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1건

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Personal Protective Equipment (PPE) · 1건

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

안전 데이터

wgk
3
tsca
TSCA listed
rtecs
MA4550000
ridadr
UN 2811 6.1/PG 2
독성
LD50 in male mice (mg/kg): 20.1 ±1.41 i.v., 43.0 ±1.8 s.c.; LD50 in male rats (mg/kg): 16.3 ±1.24 i.v., 23.5 ±1.67 i.p (Hahn, Oberdorf)
HS 번호
2933399990
risk_code
23/24/25
hazard_code
T
safety_code
22-36/37/39-45
포장분류
II
위험 등급
6.1(a)
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