D-글루탐 산
D-글루탐산 · D-글루탐산(D-GLUTAMICACID) · D-GLUTAMIC ACID · D-GLU · D-GLUCURONOLACTONE · H-D-GLU-OH · D-Glutamate · d-glutamic
식별자 및 물리적 특성
| CAS No. | 6893-26-1 |
|---|---|
| 분자식 | C5H9NO4 |
| 평균 분자량 | 147.13 g/mol |
| 단동위원소 질량 | 147.05315777 g/mol |
| SMILES | N[C@H](CCC(=O)O)C(=O)O |
| InChIKey | WHUUTDBJXJRKMK-GSVOUGTGSA-N |
| PubChem CID | 23327 |
| ChEMBL | CHEMBL76232 |
| ChEBI | CHEBI:15966 |
| EC No. | 230-000-8 |
| DTXSID | DTXSID1048675 |
| 현지명 | D-글루탐 산 |
화학 및 물리적 성질
| XLogP | -3.7 |
|---|---|
| 극성 표면적 | 101 |
| 수소 결합 공여자 수 | 3 |
| 수소 결합 수용자 수 | 5 |
| 회전 가능 결합 수 | 4 |
| 무거운 원자 수 | 10 |
| 형식 전하 | 0 |
| 복잡도 | 145 |
| 물질 분류 | Biological Agents -> Amino Acids and Derivatives |
| 의약품 | Pharmaceuticals -> Listed in ZINC15 |
| 용해도 | 8.88 mg/mL at 25 °C물(약간 용해됨) |
| 녹는점 | 201 °C200-202 °C (subl.)(lit.) |
| Physical Description | Shinny solid[Merck Index] White crystalline powder[Alfa Aesar MSDS] |
| 끓는 점 | 267.21°C (rough estimate) |
| 밀도 | 1.5380 |
| 굴절률 | 1.4210 (estimate) |
| 저장 조건 | Keep in dark place,Sealed in dry,Room Temperature |
| pKa(산도 계수) | pK1:2.162(＋1)pK2:4.272(0)pK3:9.358(－1) (25°C) |
| 물리적 상태 | 가루 |
| 색상 | 흰색에서 황백색까지 |
| 용해도 | 7g/L(20℃) |
| Merck | 14,4469 |
| BRN | 1723800 |
| InChI | 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 |
| InChIKey | WHUUTDBJXJRKMK-GSVOUGTGSA-N |
| SMILES | N[C@H](CCC(O)=O)C(O)=O |
| LogP(분배 계수) | -0.969 (est) |
| NIST | D-Glutamic acid(6893-26-1) |
| EPA | D-Glutamic acid (6893-26-1) |
화학적 성질
White cryst. powder
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 83.3% (5 of 6) of all reports.WarningH315 (16.7%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 6 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | D-Glutamic acid: Does not have an individual approval but may be used under an appropriate group standard |
| 유해성 요약 | May cause irritation[Alfa Aesar MSDS] |
| Hazard Classes and Categories | Skin Irrit. 2 (16.7%) |
| 수질 위해 등급(WGK) | 3 |
| TSCA 등재 상태 | TSCA listed |
| 관세 코드 | 29224200 |
| 위험 문구(R) | 36/37/38 |
| 위험 표시 | Xi |
| 안전 문구(S) | 24/25-36-26 |
| 기존화학 물질 | KE-17766 |
| F 고인화성물질 | 10 |
| 저장 분류 | 11 - Combustible Solids |
용도
용도
D-Glutamic Acid is the unnatural (R)-enantiomer of Glutamic Acid, a non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. Glutamic Acid is also a key molecule in cellular metabolism.
일반 설명
D-Glutamic acid is an essential constituent of the bacterial peptidoglycan structure. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor. Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan.