(S)-리소필린
(S)-리소필린 · (S)-Lisofylline · (S)-Lisophylline · (S)-Lisofylline Exclusive · (S)-Lisofylline, 10 mM in DMSO · (S)Lisofylline,(S) Lisofylline · 1-[(5S)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione · 1H-Purine-2,6-dione, 3,7-dihydro-1-[(5S)-5-hydroxyhexyl]-3,7-dimethyl-
식별자 및 물리적 특성
| CAS No. | 100324-80-9 |
|---|---|
| 분자식 | C13H20N4O3 |
| 평균 분자량 | 280.32 g/mol |
| SMILES | C[C@H](O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O |
| InChIKey | NSMXQKNUPPXBRG-VIFPVBQESA-N |
| PubChem CID | 23519621 |
| ChEMBL | CHEMBL4300766 |
| ChEBI | CHEBI:143564 |
| 현지명 | (S)-리소필린 |
화학 및 물리적 성질
| 저장 조건 | Store at -20°C |
|---|---|
| 용해도 | ≤15mg/ml in ethanol3mg/ml in DMSO12mg/ml in dimethyl formamide |
| 물리적 상태 | 결정질 고체 |
| 색상 | Off-white to light yellow |
용도
개요
LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent. (S)-LSF is the pharmacologically inactive optical enantiomer of (R)-LSF, the biologically active isomer. When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-LSF formation. Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline.
용도
LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent. (S)-LSF is the pharmacologically inactive optical enantiomer of (R)-LSF, the biologically active isomer. When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-LSF formation. Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline.[Cayman Chemical]