기본 정보
- CAS
903580-39-2- 표준 SMILES
COc1cc(Cl)cc(C(C)Nc2cc(N3CCNCC3)ccc2S(C)(=O)=O)c1OC.Cl- InChIKey
PILCQJJJAFRKHO-UHFFFAOYSA-N- 분자식
- C21H29Cl2N3O4S
- 평균 분자량
- 490.4 g/mol
- 단동위원소 질량
- 489.12558277
이름 및 식별자
- 우선 이름
- Prx-07034
- IUPAC
- N-[1-(5-chloro-2,3-dimethoxyphenyl)ethyl]-2-methylsulfonyl-5-piperazin-1-ylaniline;hydrochloride
- 영어명
- PRX 07034
- 분자식
- C21H28ClN3O4S.ClH
- 분자량
- 490.45
이름 및 동의어
903580-39-2PRX-07034PRX-07034 hydrochloride336H22ETCGUNII-336H22ETCGBenzenemethanamine, 5-chloro-2,3-dimethoxy-alpha-methyl-N-(2-(methylsulfonyl)-5-(1-piperazinyl)phenyl)-, hydrochloride (1:1)N-[1-(5-chloro-2,3-dimethoxyphenyl)ethyl]-2-methanesulfonyl-5-(piperazin-1-yl)aniline hydrochlorideBENZENEMETHANAMINE, 5-CHLORO-2,3-DIMETHOXY-.ALPHA.-METHYL-N-(2-(METHYLSULFONYL)-5-(1-PIPERAZINYL)PHENYL)-, HYDROCHLORIDE (1:1)N-(1-(5-chloro-2,3-dimethoxyphenyl)ethyl)-2-methanesulfonyl-5-(piperazin-1-yl)aniline hydrochlorideRefChem:176772N-(1-(5-Chloro-2,3-dimethoxyphenyl)ethyl)-2-(methylsulfonyl)-5-(piperazin-1-yl)aniline hydrochloridePRX 07034
이름 더 보기
PRX-07034 hydrochloride, 10 mM in DMSON-[1-(5-chloro-2,3-dimethoxyphenyl)ethyl]-2-methylsulfonyl-5-piperazin-1-ylaniline:hydrochloride5-Chloro-2,3-dimethoxy-α-methyl-N-[2-(methylsulfonyl)-5-(1-piperazinyl)phenyl]benzeneacetamide hydrochlorideBenzenemethanamine, 5-chloro-2,3-dimethoxy-α-methyl-N-[2-(methylsulfonyl)-5-(1-piperazinyl)phenyl]-, hydrochlorideBenzenemethanamine, 5-chloro-2,3-dimethoxy-α-methyl-N-[2-(methylsulfonyl)-5-(1-piperazinyl)phenyl]-, hydrochlorideBenzenemethanamine, 5-chloro-2,3-dimethoxy-α-methyl-N-[2-(methylsulfonyl)-5-(1-piperazinyl)phenyl]-, monohydrochlorideBenzenemethanamine, 5-chloro-2,3-dimethoxy-α-methyl-N-[2-(methylsulfonyl)-5-(1-piperazinyl)phenyl]-, hydrochloride (1:1)flexibility,5-HT6,PRX 07034,working,Serotonin Receptor,cognitive,Inhibitor,inhibit,PRX 07034 hydrochloride,memory,PRX07034,5-HT Receptor,5-hydroxytryptamine Receptor,PRX07034 hydrochloride
PRX-07034 (hydrochloride)Benzenemethanamine, 5-chloro-2,3-dimethoxy-alpha-methyl-N-[2-(methylsulfonyl)-5-(1-piperazinyl)phenyl]-, monohydrochlorideBenzenemethanamine, 5-chloro-2,3-dimethoxy-|A-methyl-N-[2-(methylsulfonyl)-5-(1-piperazinyl)phenyl]-, monohydrochlorideN-[1-(5-Chloro-2,3-dimethoxyphenyl)ethyl]-2-methylsulfonyl-5-piperazin-1-ylaniline hydrochlorideN-[1-(5-chloro-2,3-dimethoxyphenyl)ethyl]-2-methylsulfonyl-5-piperazin-1-ylaniline;hydrochlorideMFCD25976674C21H29Cl2N3O4SSCHEMBL475692
데이터베이스 식별자
- CAS
903580-39-2- PubChem CID
- 23653584
- DTXSID
DTXSID201029352- UNII
- 336H22ETCG
물성
구조 계산 물성
- 극성 표면적
- 88.3 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 31
- 형식 전하
- 0
- 복잡도
- 641
물리화학적 성질
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- DMSO에 용해됨
- 물리적 상태
- Solid
- 색상
- White to off-white
- InChI
- InChI=1S/C21H28ClN3O4S.ClH/c1-14(17-11-15(22)12-19(28-2)21(17)29-3)24-18-13-16(25-9-7-23-8-10-25)5-6-20(18)30(4,26)27;/h5-6,11-14,23-24H,7-10H2,1-4H3;1H
- InChIKey
- PILCQJJJAFRKHO-UHFFFAOYSA-N
- SMILES
- N(C1C=C(N2CCNCC2)C=CC=1S(=O)(=O)C)C(C1C=C(C=C(C=1OC)OC)Cl)C.Cl
화학 및 산업
약리 정보
Mechanism of Action
PRX-07034 is a novel, highly selective, small-molecule antagonist of a specific G-protein coupled receptor (GPCR) known as 5-HT6 being developed for the treatment of obesity, Alzheimer's disease and cognitive impairment associated with schizophrenia. PRX-07034 has also been shown to enhance cognitive function in preclinical animal models of memory impairment through a dual mechanism of action.It has an effect on both the acetylcholine and glutamate neurotransmitter systems in the brain, which makes it a potentially complementary therapy to cholinesterase inhibitors, a class of drugs approved for the treatment of Alzheimer's disease.
공급사22 곳
Hangzhou IKSChem Technology Co., Limited13625816949 · [email protected]
南京腾怡生物科技有限公司17714337195 · [email protected]
上海楼岚生物科技有限公司021-52996696，15000506266 15000506266
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
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江苏艾康生物医药研发有限公司025-66113011 19370895928 · [email protected]
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Aladdin Scientific[email protected]
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