기본 정보
- CAS
7758-04-5- 표준 SMILES
O=S(=O)([O-])NC1CCCCC1.[K+]- InChIKey
PALPTWOXTUVPKA-UHFFFAOYSA-M- 분자식
- C6H12KNO3S
- 평균 분자량
- 217.33 g/mol
- 단동위원소 질량
- 217.0174959
이름 및 식별자
- 우선 이름
- Potassium Cyclamate
- IUPAC
- potassium N-cyclohexylsulfamate
이름 및 동의어
POTASSIUM CYCLAMATEPotassium cyclohexylsulfamateCyclamate potassiumMonopotassium cyclohexylsulfamateMonopotassium cyclohexanesulfamate7758-04-50DS7R9NQB0Potassium cyclohexanesulfamatePotassium cyclohexyl sulfamatePotassium N-cyclohexylsulfamateCyclohexanesulfamic acid, monopotassium saltSulfamic acid, cyclohexyl-, monopotassium salt
이름 더 보기
DTXSID60228248Cyclamate, PotassiumRefChem:175452DTXCID80150739HSDB 1239N-Cyclohexylsulfamate de potassium [French]UNII-0DS7R9NQB0potassium;N-cyclohexylsulfamate
데이터베이스 식별자
- CAS
7758-04-5- PubChem CID
- 23675766
- DTXSID
DTXSID60228248- UNII
- 0DS7R9NQB0
- Nikkaji
- J1.561.357B
물성
구조 계산 물성
- 극성 표면적
- 77.6 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 2
- 무거운 원자 수
- 12
- 형식 전하
- 0
- 복잡도
- 205
실험 및 물리화학적 성질
Chemical ClassesOther Uses -> Food Additives
TasteSWEET TASTE
Food AdditivesNON-NUTRITIVE SWEETENER -> FDA Substance added to food
Color/FormCRYSTALS
Physical DescriptionSolid; [HSDB]
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Hazards Summary
After very high oral doses, dogs and cats have vomiting; About 20-40% of cyclamate is absorbed; Gut bacteria convert some of cyclamate into cyclohexylamine which is almost completely absorbed and excreted in urine; [HSDB] See Cyclamic acid. See Sodium cyclamate.
독성 정보
Human Toxicity Excerpts
HUMAN SUBJECTS HAVE CONSUMED 5 TO 12 G/DAY FOR SEVERAL WEEKS; THE ONLY NOTED EFFECT WAS A CHANGE IN STOOLS TO A MUSHY CONSISTENCY. NOT ALL SUBJECTS HAD INCREASED FREQUENCY OF BOWEL MOVEMENTS, BUT IN SOME, CATHARTIC ACTION MAY BE DUE TO OSMOTIC FLUID RETENTION BY UNABSORBED CYCLAMATE. /SODIUM CYCLAMATE/
3 PT DESCRIBED DEVELOPED VESICAL CARCINOMA OF BLADDER AFTER PROLONGED PERIOD OF INGESTION OF UNUSUALLY HIGH AMT OF CYCLAMATE SWEETNER, SEVERITY APPEARED IN PROPORTION TO DOSE INGESTED.
THE LACK OF ASSOCIATION BETWEEN SACCHARIN, CYCLAMATE, & HUMAN BLADDER CANCER IS DISCUSSED. /PRC- CONTROVERSIAL/
IN VIVO, CYCLAMATE IS CONVERTED INTO CYCLOHEXYLAMINE WHICH PER SE OR AFTER BIOTRANSFORMATION MAY PROVIDE AN ULTIMATE CARCINOGEN. /CYCLAMATE/
Non-Human Toxicity Excerpts
/ACUTE ORAL DOSES 10-17 G/KG IN MICE/...SHOW ONLY INTESTINAL FLUID ACCUMULATION & SLIGHT CARDIAC DISTENSION WITH DEATH OCCURRING IN 1 TO 24 HR. IV ADMIN OF 4-5 G/KG PRODUCES RAPID EXITUS APPARENTLY IN RESPIRATORY FAILURE. VOMITING OCCURS IN DOGS & CATS AFTER LARGE ORAL DOSES. /SODIUM CYCLAMATE/
화학 및 산업
약리 정보
Metabolism/Metabolites
...BIOTRANSFORMATION IN RATS...IS BROUGHT ABOUT BY GUT MICROFLORA. ...GUT MICROFLORA IN MAN & IN ANIMALS ACQUIRE CAPACITY TO METABOLIZE CYCLAMATE INTO CYCLOHEXYLAMINE, WHEN CYCLAMATE IS ADMIN CHRONICALLY. /CYCLAMATE/
GUT MICRO-ORGANISMS, WHICH BECOME CYCLAMATE "CONVERTERS" ARE CLOSTRIDIA IN RATS, ENTEROBACTERIA IN RABBITS, & ENTEROCOCCI IN MAN. /CYCLAMATE/
MeSH Pharmacological ClassificationSubstances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed)
Absorption, Distribution and Excretion
...CYCLOHEXYLAMINE FORMED IN INTESTINE IS ALMOST COMPLETELY ABSORBED & EXCRETED IN URINE, IN COMPARISON TO CYCLAMATE, WHICH IS ABSORBED TO AN EXTENT OF ONLY 20-40%. /CYCLAMATE/
...(14)C-CYCLAMATE, GIVEN IV TO WOMEN UNDERGOING THERAPEUTIC ABORTION, BY ABDOMINAL HYSTERECTOMY DURING EARLY PREGNANCY, CROSSED PLACENTA & DISPERSED IN FETAL TISSUES, PARTICULARLY IN LIVER, SPLEEN, PANCREAS, & KIDNEYS. ...MATERNAL BLOOD LEVELS...FELL RAPIDLY...INDICATING VERY RAPID ELIMINATION... /CYCLAMATE/
MAX DAILY EXCRETION OF CYCLOHEXYLAMINE...RANGED FROM 0.1 TO 0.9% OF DAILY CYCLAMATE INTAKE (5 G); URINARY OUTPUT OF CYCLOHEXYLAMINE WAS ERRATIC & CONTINUED FOR 3-4 DAYS AFTER ADMIN HAD CEASED. /CYCLAMATE/
용도 및 제조
Uses
Used as non-nutritive sweetener; [HSDB]
NON-NUTRITIVE SWEETENER
관련 반응
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