숙신산메틸프레드니졸론나트륨
Methylprednisolone sodium succinate
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기본 정보
- CAS
2375-03-3- 표준 SMILES
C[C@H]1C[C@@H]2[C@H]([C@@H](O)C[C@@]3(C)[C@H]2CC[C@]3(O)C(=O)COC(=O)CCC(=O)[O-])[C@@]2(C)C=CC(=O)C=C12.[Na+]- InChIKey
FQISKWAFAHGMGT-SGJOWKDISA-M- 분자식
- C26H33NaO8
- 평균 분자량
- 496.532 g/mol
- 단동위원소 질량
- 496.2073123
이름 및 식별자
- 우선 이름
- Methylprednisolone sodium succinate
- IUPAC
- Sodium 4-[(11beta,17-dihydroxy-6alpha-methyl-3,20-dioxopregna-1,4-dien-21-yl)oxy]-4-oxobutanoate
- 현지명
- 숙신산메틸프레드니졸론나트륨
- 영어명
- Methylprednisolone sodium succinate
- 분자식
- C26H33O8.Na
- 분자량
- 497.53
이름 및 동의어
메틸프레드니솔론소듐숙시네이트6알파-메틸프레드니솔론숙신산나트륨METHYLPREDNISOLONE SODIUM SUCCINATEMethylprednisolone succinate sodium6α-methylprednisolone 21-hemisuccinate sodium salt6α-Methylprednisolone 21-hemisuccinate sodium salt1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-SUCCINATE, SODIUM SALT6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT(6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium saltu9088MetypredNSC 48989
데이터베이스 식별자
- CAS
2375-03-3- PubChem CID
- 23680530
- DTXSID
DTXSID2023303- ChEMBL
CHEMBL1201081- ChEBI
CHEBI:6890- UNII
- LEC9GKY20K
- EC Number
- 219-156-8
- Nikkaji
- J7.880H
물성
물리화학적 성질
- 녹는점
- 186 °C · >186°C (dec.)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 동결건조된 분말
- 산도 계수 (pKa)
- 4.5 · 4.5
- 색상
- 흰색에서 황백색까지
- 생물학적 소스
- synthetic
- 수용성
- 50 mg/mL, · water: 50mg/mL, clear, colorless to faintly yellow
- InChIKey
- FQISKWAFAHGMGT-JXAFMBTDNA-M
- SMILES
- [C@]12(C[C@@H](C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@H](C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)CCC([O-])=O)O)C)[H].[Na+] |&1:0,2,9,11,13,15,17,20,r|
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- rtecs
- TU4154060
- 독성
- LD50 oral in rat: > 5gm/kg
- risk_code
- 61-40
- hazard_code
- T
- safety_code
- 53-22-36/37/39-45
- 기존화학 물질
- KE-04857
- Hazard Classifications
- Carc. 2Repr. 1B
- 스토리지 클래스
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
화학 및 산업
응용 분야
개요Methylprednisolone Sodium Succinate is the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. It is converted into active prednisolone in the body, which activates glucocorticoid receptor-mediated gene expression. This includes inducing the synthesis of the anti-inflammatory protein IkappaB-alpha and inhibiting the synthesis of nuclear factor kappa B (NF-kappaB). As a result, proinflammatory cytokine production, such as IL-1, IL-2, and IL-6, is down-regulated, and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.
용도6α-Methylprednisolone 21-Hemisuccinate is a glucocorticosteroid used in anti-inflammatory medication in the treatment of spinal cord injuries.
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