삼염화아세트산 나트륨

Fresh air, rest. Refer for medical attention.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

... The effects of treatment of pregnant Long-Evans rats with combined aqueous solutions of dichloroacetic acid (DCA) at 0, 140, 1,400 and 1,900 mg/kg/day and trichloroacetic acid (TCA) at 0, 50, 500, 800 mg/kg/day. The study /utilized/ a segment II protocol with intubation on gestation days 6-15 (plug = 0). ... All fetuses were fixed in Bouin's soln for Wilson's sectioning. A factorial design was used with 15-30 rats randomized to each of sixteen dose combinations. Twenty-two of 280 dams died. ... There was evidence of a synergistic interaction for the percent change in dam body weight from gestation day 6-9 and an antagonistic interaction for the spleen and average kidney weight, the proportion of resorbtions, heart and total visceral malformations, and affected fetuses. The results from the nested analysis of variance indicated that a significant interaction exists between TCA and DCA for individual pup weights and crown to rump lengths. ...

TERRESTRIAL FATE: When released to moist soil, sodium trichloroacetate will dissociate to the trichloroacetate ion given a pKa of 0.64(1). It will then behave like trichloroacetate. Volatilization from dry soil surfaces is not expected as this compound is a salt and thus it will not partition to the atmosphere(SRC).

AQUATIC FATE: When released to water, sodium trichloroacetate will dissociate to the trichloroacetate ion given a pKa of 0.64(1).

ATMOSPHERIC FATE: Because sodium trichloroacetate is a salt, it will not partition to the atmosphere. (SRC)

Cough. Sore throat.

Redness. Pain.

Redness. Pain.

When released to moist soil, sodium trichloroacetate with a pKa of 0.64(1) will exist in the environment as the trichloroacetate ion. Sodium trichloroacetate has greater mobility in high pH soils than in more acidic soils; this is due to the ionic character of this compound(2).

The sodium salt of TCA caused an occupational problem when it was used for 5.5 months each year to control grass and weeds in pavement in the tropics. The workers had been provided with good dermal protection but with no face shields, goggles, or masks. The eight members and one foreman of a spray team complained of coughing and/or pains in the chest, and some complained of sore throat and burning eyes. Many symptoms were worse at night. The foreman, who had been employed 2.5 years, had irritation of the trachea, and he was fatigued and short of breath at night. His eyes itched by day and even more so by night when they also burned. On windy days his eyes became markedly swollen.

It is established that sodium trichloroacetate does ... incr chromosome aberration frequency in the culture of human peripheral lymphocytes. ...

An estimated BCF value of 0 was calculated for sodium trichloroacetate(SRC), using a measured water solubility of 1.2X10+6 mg/l(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

When released to water or moist soil, sodium trichloroacetate will dissociate to the trichloroacetate ion given a pKa of 0.64(1). Volatilization from dry soil surfaces is not expected as this compound is a salt and thus will not partition to the atmosphere(SRC).

Wild geese are believed to have been killed after a clover field had been sprayed /with/ this cmpd.

A new approach to insect control using sodium trichloroacetate to inhibit synthesis of the hydrophobic cuticular lipids that protect from dehydration was tested on Triatoma infestans. In vivo and in vitro studies of the incorporation of radioactive precursors showed diminished cuticular hydrocarbon synthesis after /cmpd/ treatment. ...

A study was made of the incidence and types of adverse developmental sequelae induced in the offspring of pregnant Long-Evans rats exposed orally to trichloroacetic acid (TCA) in the form of sodium trichloroacetate. Animals were dosed by oral intubation on gestation days 6 through 15 with 0, 330, 800, 1200 or 1800 mg/kg/day. The vehicle control was distilled water. No maternal deaths occurred which were related to trichloroacetic acid /admin/. Weight gain during treatment was reduced at 800 and higher dose levels. Spleen and kidney weights were incr in a dose related manner. The mean percent of resorbed implants per litter was 34, 62, and 90 at 800, 1200 and l800 mg/kg, respectively. Live fetuses showed dose dependent reductions in weight and length. The mean frequency of soft tissue malformations ranged from 9% at the low dose to 97% at the high dose. These were principally in the cardiovascular system. Skeletal malformations were noted only at the 1200 and 1800 mg/kg dose levels and were mainly in the orbit. TCA was considered to be developmentally toxic in the pregnant rat at doses of 330 mg/kg and above.

It is established that sodium trichloroacetate does not induce chromosomal aberrations in bone marrow cells of mice, does not modify mutagenic effect induced by rubidomicin ... and in germs of Crepis tectorum and Allium cepa seeds.

For more Non-Human Toxicity Excerpts (Complete) data for SODIUM TRICHLOROACETATE (8 total), please visit the HSDB record page.

Tolerances for residues removed.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Sodium trichloroacetate is found on List D. Case No: 4089; Pesticide type: herbicide; Case Status: No products containing the pesticide are actively registered ... The case /is characterized/ as "cancelled." Under FIFRA, pesticide producers may voluntarily cancel their registered products. EPA also may cancel pesticide registrations if registrants fail to pay required fees or make/meet certain reregistration commitments, or if EPA reaches findings of unreasonable adverse effects.; Active ingredient (AI): Sodium trichloroacetate; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."