기본 정보
- CAS
59170-23-9- 표준 SMILES
COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC- InChIKey
HXLAFSUPPDYFEO-UHFFFAOYSA-N- 분자식
- C20H27NO4
- 평균 분자량
- 345.4 g/mol
- 단동위원소 질량
- 345.19400834
개요
Bevantolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by 3-methylphenyl and one of the hydrogens attached to the nitrogen is substituted by 2-(3,4-dimethoxyphenyl)ethyl. A beta1 adrenoceptor antagonist, it has been shown to be as effective as other beta-blockers for the treatment of angina pectoris and hypertension. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, an anti-arrhythmia drug and a calcium channel blocker.
이름 및 식별자
- 우선 이름
- Bevantolol
- IUPAC
- 1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol
- 영어명
- Bevantolol
- 분자식
- C20H27NO4
- 분자량
- 345.43
이름 및 동의어
Bevantolol59170-23-9Bevantololum1-(3,4-Dimethoxyphenethylamino)-3-(m-tolyloxy)-2-propanol(+-)-bevantolol1-((2-(3,4-Dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-2-propanolNSC-13234834ZXW6ZV211-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(3-methylphenoxy)propan-2-ol1-(3,4-dimethoxyphenethylamino)-3-m-tolyloxy-propan-2-olCHEBI:238698DTXSID70860597
이름 더 보기
Bevanolol.NSC 132348DL-BevantololBevantolol USP/EP/BP1-((3,4-DiMethoxyphenethyl)aMino)-3-(M-tolyloxy)propan-2-ol1-[(3,4-Dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol1-(3,4-Dimethoxyphenethylamino)-3-(3-methylphenoxy)-2-propanol2-Propanol, 1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-
1-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-3-m-tolyloxy-propan-2-olCI-7751-(2-(3,4-Dimethoxy-phenyl)-ethylamino)-3-m-tolyloxy-propan-2-ol1-((2-(3,4-dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)propan-2-olRefChem:119574C07AB06DTXCID80197265Bevantololum [INN-Latin]
데이터베이스 식별자
- CAS
59170-23-9- PubChem CID
- 2372
- DTXSID
DTXSID70860597- ChEMBL
CHEMBL314010- ChEBI
CHEBI:238698- UNII
- 34ZXW6ZV21
- Nikkaji
- J12.450H
물성
구조 계산 물성
- XLogP
- 3
- 극성 표면적
- 60 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 10
- 무거운 원자 수
- 25
- 형식 전하
- 0
- 복잡도
- 355
실험 및 물리화학적 성질
LogP
3.00
3.0
Solubility1.37e-02 g/L
Melting Point
137-138 °C
137 - 138 °C
Physical DescriptionSolid
물리화학적 성질
- 저장 조건
- 2 · 2-8°C
화학 및 산업
약리 정보
ATC Code
C - Cardiovascular system
QC - Cardiovascular system
PharmacodynamicsBevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension.
Mechanism of Action
Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors. By binding and antagonizing beta-1 receptors Bevantolol inhibits the normal normal epinephrine-mediated sympathetic actions such as increased heart rate. This has the effect of decreasing preload and blood pressure.
MeSH Pharmacological ClassificationDrugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS.
Cellular LocationsMembrane
Metabolite PathwaysBevantolol Action Pathway
상·하류 제품 정보
상류 원료
공급사11 곳
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
绵阳万迪诺医药科技有限公司15681201579 15861805752 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
江苏艾康生物医药研发有限公司025-58859352 13913916777 · [email protected]
湖北摩科化学有限公司18627753421; 18627756402 · [email protected]
ANHUI WITOP BIOTECH CO., LTD+8618071025641 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
Alchem Pharmtech,Inc.8485655694 · [email protected]
南京宁吉通医药生物科技有限公司0-19710401727 19710401727 · [email protected]
Dideu Industries Group Limited+86-29-81148696 +86-15129568250 · [email protected]
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