6-Chloroguanosine
6-CHLOROGUANOSINE · 6-Cl-Gr · NSC 44586 · 2-Amino-6-chL · 6-CHLOROADENOSINE · 6-Chloroguanosine2 · oropurine riboside · endogenous protein
식별자 및 물리적 특성
| CAS No. | 2004-07-1 |
|---|---|
| 분자식 | C10H12ClN5O4 |
| 평균 분자량 | 301.69 g/mol |
| SMILES | Nc1nc(Cl)c2ncn(C3OC(CO)C(O)C3O)c2n1 |
| InChIKey | TXWHPSZYRUHEGT-ACJOCUEISA-N |
| PubChem CID | 239492 |
| ChEMBL | CHEMBL34117 |
| DTXSID | DTXSID90942041 |
화학 및 물리적 성질
| XLogP | -0.1 |
|---|---|
| 극성 표면적 | 140 |
| 수소 결합 공여자 수 | 4 |
| 수소 결합 수용자 수 | 8 |
| 회전 가능 결합 수 | 2 |
| 무거운 원자 수 | 20 |
| 형식 전하 | 0 |
| 복잡도 | 367 |
| 녹는점 | 165-167 °C (dec.)(lit.) |
| 끓는 점 | 729.9±70.0 °C(Predicted) |
| 밀도 | 1.8359 (rough estimate) |
| 굴절률 | -38 ° (C=0.1, H2O) |
| 저장 조건 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 용해도 | DMSO및메탄올에 용해됨 |
| 물리적 상태 | 가루 |
| pKa(산도 계수) | 13.05±0.70(Predicted) |
| 색상 | 흰색에서 황백색까지 |
| InChIKey | TXWHPSZYRUHEGT-ACJOCUEISA-N |
화학적 성질
Colourless Crystalline Solid
안전 및 규제
| 수질 위해 등급(WGK) | 3 |
|---|---|
| 관세 코드 | 29349990 |
| 위험 문구(R) | 36/37/38 |
| 위험 표시 | Xi |
| 안전 문구(S) | 24/25-36-26 |
| 위험 참고 사항 | Irritant |
용도
용도
2-Amino-6-chloropurine riboside (1) is a a novel class of inhibitors of endogenous protein degradation for the preparation of a number of important purine nucleoside derivatives. For example, 6-thioguanosine 2 and 6-selenoguanosine 3 were prepared from a reaction of 1 and the corresponding sodium thiosulfate or potassium selenosulfate.1) 18O-labeled guanosine 4 was incubated from 1 with adenosine deaminase in (18O)-water.2) 2-Amino-6-ethoxypurine riboside 5 and 2-amino-N6-amino-N6-methyladenosine 6 were prepared by treatment of 1 with nucleophiles, sodium ethoxide and methylhydrazine, respectively.3,4) 2-Amino-N6-substituted purine analogues, as typified by 6, were reported as anti-malarial active compounds.