Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
인산 나트륨, 이염기성, 도데카수화물
디나트륨수소인산염12H2O · 디-나트륨수소인산염-12수화물 · 디나트륨인산염도데카수화물 · 모노수소나트륨인산염 · 인산나트륨,이염기 · 인산이나트륨 · 인산,디나트륨염,12-수화물 · 디나트륨인산염(NA2HPO4.12H20)
식별자 및 물리적 특성
| CAS No. | 10039-32-4 |
|---|---|
| 분자식 | Na2HPO4 |
| 평균 분자량 | 141.959 g/mol |
| 단동위원소 질량 | 141.9407837 g/mol |
| SMILES | O=P([O-])([O-])O.[Na+].[Na+] |
| InChIKey | BNIILDVGGAEEIG-UHFFFAOYSA-L |
| PubChem CID | 24203 |
| ChEMBL | CHEMBL1060 |
| ChEBI | CHEBI:34683 |
| EC No. | 231-448-7 |
| DTXSID | DTXSID1026039 |
| 현지명 | 인산 나트륨, 이염기성, 도데카수화물 |
화학 및 물리적 성질
| 극성 표면적 | 83.4 |
|---|---|
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 4 |
| 회전 가능 결합 수 | 0 |
| 무거운 원자 수 | 7 |
| 형식 전하 | 0 |
| 복잡도 | 46.5 |
| 물질 분류 | Metals -> Phosphates, Metallic Salts |
| 화장품 | Cosmetic ingredients (Disodium Phosphate) -> CIR (Cosmetic Ingredient Review)Buffering |
| pH | Between 8,4 and 9,6 (1 % solution)pH = 9.1 for 1% aq soln at 25 °C9.0-9.3 (25℃, 50mg/mL in H2O) |
| LogP(분배 계수) | -5.8 (calculated) |
| 냄새 | NONE냄새 없는 |
| 맛 | Saline taste |
| 식품 첨가물 | ANTICAKING AGENT OR FREE-FLOW AGENT, ANTIMICROBIAL AGENT, DRYING AGENT, EMULSIFIER OR EMULSIFIER SALT, FLAVOR ENHANCER, FLAVORING AGENT OR ADJUVANT, MALTING OR FERMENTING AID, PH CONTROL AGENT, STABILIZER OR THICKENER, TEXTURIZER -> FDA Substance added to food |
| 밀도 | 1.8 to 2.5 at 77 °F (USCG, 1999)approx 1.7 g/cu cmDensity 1.679, loses 5H2O at 48 °C /Disodium phosphate heptahydrate/MP 35 °C, density 1.5235, readily loses 12H2O at 100 °C /Disodium phosphate dodecahydrate/0.5-1.2 g/cm³1,52 g/cm3 |
| Color/Form | Colorless, translucent crystals or white powder.White, hygroscopic powder |
| 용해도 | greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)Freely soluble in water. Insoluble in ethanolColorless crystals11.8 G sol in 100 cc water at 25 °C /Disodium phosphate heptahydrate/100 g sol in 100 ml water at 50 °C117 g sol in 100 ml water at 80 °C. /Disodium phosphate dihydrate/11.8 g sol in 100 ml water at 25 °C /Disodium phosphate dodecahydrate/11.8 g/100 g water at 25 °CH2O: 0.1 M at 20 °C, 투명, 무색 |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Animal Drugs | Pharmaceuticals -> UK Veterinary Medicines Directorate List |
| 녹는점 | 35 °C |
| 저장 조건 | Store at +15°C to +25°C. |
| 물리적 상태 | 크리스탈 |
| 색상 | 하얀색 |
| 용해도 | 218g/L(20℃) |
| InChI | InChI=1S/2Na.H3O4P.12H2O/c1-5(2,3)4/h(H3,1,2,3,4)12*1H2/q2*+1/p-2 |
| InChIKey | DGLRDKLJZLEJCY-UHFFFAOYSA-L |
| SMILES | P([O-])([O-])(=O)O.O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+] |
| EPA | Disodium phosphate dodecahydrate (10039-32-4) |
화학적 성질
white crystals
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 70.3% (744 of 1059) of all reports.WarningH319 (29.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)Aggregated GHS information provided per 1059 reports by companies from 12 notifications to the ECHA C&L Inventory.This chemical does not meet GHS hazard criteria for 100% (11 of 11) of all reports. |
|---|---|
| 규제 정보 | Chemical: Phosphoric acid, disodium saltPhosphoric acid, sodium salt (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphoric acid, sodium salt (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 26-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14974Sodium phosphate, dibasic: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| 기타 안전 정보 | IMAP assessments - Phosphoric acid, disodium salt: Human health tier I assessment |
| 화재 위험 | Behavior in Fire: May melt with loss of steam (USCG, 1999)Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| 화재 가능성 | Nonflammable |
| 건강 유해성 | Inhalation of heavy dust may irritate nose and throat. Ingestion may injure mouth, throat, and gastrointestinal tract, resulting in nausea, vomiting, cramps and diarrheapain and burning in mouth may occur. Contact with eyes produces local irritationcan lead to chronic damage. Contact with skin produces local irritationrepeated or prolonged contact can lead to dermatitis. (USCG, 1999) |
| 유해성 요약 | A mild skin, eye, and respiratory tract irritant[ICSC] Emergency treatment: Inorganic phosphatesInorganic phosphates can cause diarrhea, hyperphosphatemia, and hypocalcemia after ingestionAn adult died after receiving four sodium phosphate enemas within 24 hourshe had electrolyte abnormalities and died from cardiac arrest[HSDB] A mild eye irritant in rabbits[RTECS] |
| FDA 요건 | Disodium phosphate used as a sequestrant in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice.Disodium phosphate used as a sequestrant in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.Sodium phosphate (mono-, di-, & tribasic) used as a multiple purpose food substance in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Sodium phosphate (mono-, di-, & tribasic)/Sodium phosphate (mono-, di-, & tribasic) used as a sequesterant in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Sodium phosphate (mono-, di-, & tribasic)/For more FDA Requirements (Complete) data for DISODIUM HYDROGEN PHOSPHATE (9 total), please visit the HSDB record page. |
| 반응성 그룹 | Salts, Basic |
| Special Reports | WHODiseases Caused by Phosphorus and Its Toxic CompoundsEarly Detection of Occupational Diseases pg 53-62 (1986). Review of diseases and health related effects resulting from exposure to phosphorus or phosphorus cmpd. |
| FIFRA 요건 | Residues of disodium phosphate are exempted from the requirement of a tolerance when used as a anticaking agent, conditioning agent in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Sodium phosphate /disodium monohydrogen phosphate/ is found on List D. Case No: 4053Pesticide type: fungicide, herbicide, antimicrobialCase Status: None of the active ingredients in the case are being supported for reregistration by their registrants. All are unsupported, or some are unsupported and some are cancelled. Cases described as "unsupported" generally are being processed for cancellation.Active ingredient (AI): sodium phosphateAI Status: The active ingredient is no longer contained in any registered products. Thus, we characterize it as "cancelled.". |
| Reactivity Profile | Strong basecorrosive towards metals e.g. aluminum and zinc. [Handling Chemicals Safely 1980 p. 947]. |
| Chemical Dangers | Decomposes on heating. This produces toxic fumes. Reacts violently with strong acids. |
| 소화 | In case of fire in the surroundings, use appropriate extinguishing media. |
| 응급 조치 | Fresh air, rest.Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. |
| 응급 처치 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| 안전 보관 | Separated from strong acids. |
| Firefighting Hazards | Behavior in fire: May melt with loss of steam. /Sodium Phosphates/ |
| 소화 절차 | If material is on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) |
| 보관 조건 | Keep well closed and in a cool place. |
| 정리 방법 | /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./Environmental Consideration: Land spill Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.Environmental Consideration: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3). Adjust pH to neutral (pH=7). Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. |
| 처리 방법 | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations. |
| 누출 처리 | Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.If material is not on fire and not involved in fire: Keep material out of water sources and sewers. Build dikes to contain flow as necessary.Personnel Protection: Keep upwind. Wear appropriate chemical protective gloves, boots and goggles. Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amounts of water or soap and water. |
| Eye Prevention | Wear safety goggles. |
| 상호 작용 | Except for D-thyroxine, the hypocholesterolemic agents tested did not prevent the formation of cardiac lesions in rats on a thrombogenic diet, being treated with large doses of disodium phosphate.Disodium phosphate increased the antirachitic activity of vitamin D3 in 3 week old rats.Concurrent use with potassium and sodium phosphates combination or monobasic potassium phosphate may increase plasma concentrations of salicylates since salicylate excretion is decreased in acidified urineaddition of these phosphates to patients stabilized on a salicylate may lead to toxic salicylate concentrations.Concurrent use with foods or medicines containing phosphates will decrease iron absorption because of the formation of less soluble or insoluble complexesiron supplements should not be taken within 1 hour before or 2 hours after ingestion of phosphates. /Phosphates/For more Interactions (Complete) data for DISODIUM HYDROGEN PHOSPHATE (8 total), please visit the HSDB record page. |
| 생태독성 수치 | LC50Species: Daphnia magna (Water flea)Condtions: freshwater, static, 21-25 °CConcentration: 1154 mg/L for 25 hrConcentration: 1089 mg/L for 50 hr |
| 독성 요약 | The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Disodium Phosphate...Safe for use in cosmetics, with qualifications |
| Signs and Symptoms | Cough. Sore throat.Redness. Pain.Abdominal pain. Diarrhoea. |
| Human Toxicity Excerpts | /SIGNS AND SYMPTOMS/ /Saline laxatives/ are tolerated reasonably well by most patients. However, they need to be used with caution or avoided in patients with renal insufficiency, cardiac disease, or preexisting electrolyte abnormalities and in patients on diuretic therapy. Under these circumstances, there should be monitoring for hypermagnesemia, hyperphosphatemia, hyperkalemia, hypernatremia, and hypocalcemia. /Saline laxatives//SIGNS AND SYMPTOMS/ The estimated fatal dose of sodium phosphates is 50 g. The corrosive effect is strong irritation and erythema, blistering. /Alkalies and phosphatesfrom table//SIGNS AND SYMPTOMS/ Inorganic phosphate poisoning following ingestion of laxatives that contain phosphate salts has been reported in adults and children. Ingestion of large amounts of sodium dihydrogen phosphate lowers urinary pH. If excessive phosphate salts are introduced intravenously or orally, they may prove toxic by reducing the concentration of Ca 2+ in the circulation and from the precipitation of calcium phosphate in soft tissues. /Phosphate ion/ /Phospahte salt laxatives//SIGNS AND SYMPTOMS/ Anhydrous form may cause mild irritation to skin, mucous membranesinternally causes purging.For more Human Toxicity Excerpts (Complete) data for DISODIUM HYDROGEN PHOSPHATE (27 total), please visit the HSDB record page. |
| Non-Human Toxicity Excerpts | /LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ To elucidate the nephrotoxicity of phosphate, dibasic sodium phosphate solution was given to Sprague-Dawley rats by daily bolus intravenous administration at concentrations of 0, 1, 25, 250, or 360 mM (0, 1, 28, 284, or 408 mg/kg Na2HPO4) for 14 days, and the kidneys were ... examined. There were no remarkable changes in blood chemistry valueshowever, urinalysis revealed mild to moderate proteinuria in the 250 and 360 mM groups. The kidneys from the 360 mM group were macroscopically pale. Histopathology revealed panglomerular deposition of basophilic dense granules, which were positive for von Kossa's staining, accompanied by dose-dependent degeneration of the glomerular epithelium and parietal epithelium in the 250 and 360 mM groups. Electron microscopic examination showed fusion of podocytes and increased microvilli, with large amounts of debris in the Bowman's space. Low-density lamellar structures were present not only in the glomerular epithelium, basement membrane, mesangial matrix and parietal epithelium but also within the Bowman's space depending on the severity of the glomerular lesion. Phosphorus and calcium were detected by X-ray microanalysis as fine particles admixed with lamellar structures. These results suggest that high-dose phosphate used in this study transiently overloads the glomerular epithelium during filtration through glomerular capillaries and produces insoluble calcium salt and glomerular lesions, resulting in proteinuria./LABORATORY ANIMALS: Neurotoxicity/ Disodium phosphate given intracerebroventricularly (ICV) in rats elicited a syndrome characterized by behavioral and EEG activation, stereotypes, hyperresponsiveness, and analgesia./VETERINARY ANIMALS/ Phosphate enema toxicity was diagnosed in a 7-month-old, castrated male, pygmy goat. On presentation, clinical findings included mild depression, tachycardia, tachypnea, rumen stasis, muscle tremors, hypocalcemia, hypokalemia, hypochloremia, hyperphosphatemia, azotemia, and metabolic acidosis. Fluid diuresis and parenteral antimicrobial therapy resulted in recovery after 3 d of treatment./VETERINARY ANIMALS/ Application of a sodium phosphate containing enema caused life-threatening metabolic disorders in a Dachshund and two cats. Clinical signs were characterised by dehydration and various neurological deficits including seizures. Most striking laboratory abnormalities were hypernatremia, hypocalcemia, hyperphosphatemia, and polycythemia. Despite intensive treatment the dog died, whereas the cats recovered completely. In face of possible severe and potentially fatal metabolic abnormalities sodium phosphate enemas, such as Practo-Clyss, should be used with caution or not at all in cats and small dogs. |
| Populations at Special Risk | /Saline laxatives/ are tolerated reasonably well by most patients. However, they need to be used with caution or avoided in patients with renal insufficiency, cardiac disease, or preexisting electrolyte abnormalities and in patients on diuretic therapy. /Saline laxatives/Phosphate should not be given to patients with impaired renal function or hyperphosphatemia. They should not be given to patients with alkaline urine due to urinary tract infections because increased calcium and phosphate concentrations in the alkaline urine increase the risk of calcium phosphate stones. /Monobasic or dibasic sodium or potassium phosphate/ |
| Probable Routes of Human Exposure | NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,230,592 workers (912,048 of these were female) were potentially exposed to disodium hydrogen phosphate in the US(1). The NOES Survey does not include farm workers. Occupational exposure to disodium hydrogen phosphate may occur through inhalation and dermal contact with this compound at workplaces where disodium hydrogen phosphate is produced or used(SRC). |
| Other Environmental Concentrations | In August of 1987, 30,000 gallons of sodium phosphate was spilled into the Arthur Krill waterway, NY(1). |
| Antidote and Emergency Treatment | Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Inorganic acids and related compounds/Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist respirations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. Activated charcoal is not effective. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Do not attempt to neutralize because of exothermic reaction. Cover skin burns with dry, sterile dressings after decontamination ... . /Inorganic acids and related compounds/Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation, at the first sign of upper airway obstruction, may be necessary. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's(LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Inorganic acids and related compounds/ |
| RAIS Toxicity Values | 1PPRTV Current4 |
| Human Toxicity Values | The estimated fatal dose of sodium phosphates is 50 g. The corrosive effect is strong irritation and erythema, blistering. /Alkalies and phosphatesfrom table/ |
| CERCLA 보고 수량 | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| 청정수법 요건 | Sodium phosphate, dibasic is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance. |
| 수질 위해 등급(WGK) | 1 |
| RTECS 번호 | TC5725000 |
| 운송 번호(UN) | UN 3077 9 / PGIII |
| 독성 | LD50 orally in Rabbit: > 2000 mg/kg |
| 관세 코드 | 28352200 |
| 안전 문구(S) | 24/25 |
| 저장 분류 | 13 - Non Combustible Solids |
용도
용도
1. 청 관제, 탄철제, 피혁탄닝, 목제의 방부제 2. 범랑제조, 염색 매연제, 안료(침전제) 3. 의약 (페 니실린, 스트렙토 마이신의 제조) 4. 전분, 인산에스테르나트륨 제조에 사용 5. 완충작용이 강 하고 식품가공의 제조시 pH조정에 사용된다. 예를 들면 분유에서 용해도를 증가시키고 어육이나 식육의 반죽제품, 치이즈등은 다른 종합인산염과 병용하여 제품의 결착력을 향상시키는데 사용된 다.
용도
Sodium Phosphate Dibasic Dodecahydrate is used in method for preparing self-supporting membrane.
일반 설명
Sodium phosphate is a colorless crystalline sodium salt. It is widely used as a buffer in molecular biology, biochemistry, and chromatographic studies. It exists in three forms: monobasic (NaH2PO4), dibasic (Na2HPO4), and tribasic (Na3PO4). Monobasic and dibasic forms in varying ratios are commonly used to compose the neutral sodium phosphate buffer solution.
제조 및 합성 방법
생산 방법
Either bone phosphate (bone ash), obtained by heating bones to whiteness, or the mineral phosphorite is used as a source of tribasic calcium phosphate, which is the starting material in the industrial production of dibasic sodium phosphate. Tribasic calcium phosphate is finely ground and digested with sulfuric acid. This mixture is then leached with hot water and neutralized with sodium carbonate, and dibasic sodium phosphate is crystallized from the filtrate.