기본 정보
- 표준 SMILES
O=P([O-])([O-])[O-].O=P([O-])([O-])[O-].[Mg+2].[Mg+2].[Mg+2]- InChIKey
GVALZJMUIHGIMD-UHFFFAOYSA-H- 분자식
- Mg3O8P2
- 평균 분자량
- 262.86 g/mol
- 단동위원소 질량
- 261.86196532
개요
Magnesium phosphate is an inorganic magnesium salt.
이름 및 식별자
- 우선 이름
- Magnesium Phosphate
- IUPAC
- trimagnesium diphosphate
이름 및 동의어
magnesium phosphate10043-83-1newberyteRefChem:925189trimagnesium orthophosphateDTXSID20904278233-142-9680-895-8684-534-5Phosphoric acid, magnesium saltPhosphoric acid, magnesium salt (1:?)7757-87-1
이름 더 보기
TRIMAGNESIUM PHOSPHATEMAGNESIUMPHOSPHATEPhosphoric acid, magnesium salt (2:3)trimagnesium;diphosphateMagnesium phosphate anhydrousMagnesium phosphate (Mg3(PO4)2)Tertiary magnesium phosphateMagnesium phosphate (3:2)
데이터베이스 식별자
- CAS
10043-83-1、53408-95-0、7757-87-1- PubChem CID
- 24439
- DTXSID
DTXSID00872527- ChEMBL
CHEMBL2106873、CHEMBL3989627- ChEBI
CHEBI:190298- UNII
- XMK14ETW2D
- EC Number
- 231-824-0、233-142-9、684-534-5
물성
구조 계산 물성
- 극성 표면적
- 173 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 0
- 무거운 원자 수
- 13
- 형식 전하
- 0
- 복잡도
- 36.8
실험 및 물리화학적 성질
Chemical ClassesMetals -> Phosphates, Metallic Salts
Polymers
Plastics -> N.a.
Plastics -> Pigments agents
Cosmetics
Cosmetic ingredients (Magnesium Phosphate) -> CIR (Cosmetic Ingredient Review)
Cosmetic ingredients (Trimagnesium Phosphate) -> CIR (Cosmetic Ingredient Review)
Opacifying; Anticaking; Bulking
Odorodorless
Tastetasteless
Food AdditivesNUTRIENT SUPPLEMENT, PH CONTROL AGENT, STABILIZER OR THICKENER -> FDA Substance added to food
DensityCrystallizes with 5, 8, and 22 H2O /molecules/ ... salts are practically insoluble in water but readily soluble in acids; density (octahydrate): 2.19; density (22 H2O): 1.66
Color/FormRHOMBIC PLATES
SolubilityINSOL IN COLD OR HOT WATER; INSOL IN LIQUID AMMONIA; SOL IN AMMONIUM SALT SOLN
Melting Point1,184 °C
Food Contact Substances
FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Physical DescriptionOdorless iridescent solid; [HSDB] White odorless powder; [MSDSonline]
안전 및 규제
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (125 of 125) of all reports.
Not Classified
Aggregated GHS information provided per 125 reports by companies from 2 notifications to the ECHA C&L Inventory.
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
유해성 정보
Regulatory Information
Chemical: Phosphoric acid, magnesium salt (2:3)
Chemical: Phosphoric acid, magnesium salt
Status: Active Update: 20-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/11587
Phosphoric acid, magnesium salt (1:?): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Phosphoric acid, magnesium salt (2:3): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety Information
IMAP assessments - Phosphoric acid, magnesium salt (2:3): Human health tier I assessment
IMAP assessments - Phosphoric acid, magnesium salt: Human health tier I assessment
Hazards SummarySee Magnesium.
FDA RequirementsSubstance added directly to human food affirmed as generally recognized as safe (GRAS).
Hazard Classes and Categories
Acute Tox. 4 (78.6%)
Skin Irrit. 2 (100%)
Not Classified
안전 및 보호
Disposal Methods
SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
독성 정보
Toxicity Summary
The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Magnesium Phosphate...
Safe for use in cosmetics, with qualifications
The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Trimagnesium Phosphate...
Safe for use in cosmetics, with qualifications
Natural Pollution SourcesOCTAHYDRATE OCCURS IN NATURE AS MINERAL BOBIERRITE.
RAIS Toxicity Values
48.6
PPRTV Archive
48.6
PPRTV Archive
EPA Provisional Peer-Reviewed Toxicity Values
Trimagnesium phosphate
4.9 x 10^1 mg/kg-day
4.9 x 10^1 mg/kg-day
PDF Document
Inadequate information to assess carcinogenic potential
2011
규제 정보
FDA RequirementsSubstance added directly to human food affirmed as generally recognized as safe (GRAS).
화학 및 산업
약리 정보
ATC Code
B - Blood and blood forming organs
QB - Blood and blood forming organs
Mechanism of ActionIT NEUTRALIZES EXCESS ACID OF STOMACH BUT PRODUCES NO EXCESS ALKALINIZATION OF SYSTEM. IT HAS MILD LAXATIVE ACTION.
Metabolism/Metabolites
...A new component of calculi, trimagnesium orthophosphate /is described/. In a microscopical study of thin sections from 3,500 urinary calculi we detected this compound in 14 stones, all of which contained struvite. New data suggest that trimagnesium orthophosphate is a transformation product of struvite. This well-crystallized substance was always detected a few days after the surgical extraction of struvite kidney stones, in contrast to the newberyite that appears on the surface of very old removed stones or after long exposure of stones to the atmosphere.
FDA Pharmacological Classification
MAGNESIUM PHOSPHATE
Stimulation Large Intestine Fluid/Electrolyte Secretion [PE]; Increased Large Intestinal Motility [PE]; Magnesium Ion Exchange Activity [MoA]; Osmotic Laxative [EPC]; Inhibition Small Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]; Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Calculi Dissolution Agent [EPC]
용도 및 제조
Uses
CIR ingredient: Magnesium Phosphate
CIR ingredient: Trimagnesium Phosphate
Octahydrate found as the mineral bobierrite; [Merck Index] Used as a plant food, dentifrice polishing agent, stabilizer for plastics, food additive, dietary supplement, anti-caking agent for silicate detergents and table salt, stabilizer for calcium phosphate dihydrate, and antacid; [HSDB]
PLANT FOOD
DENTIFRICE POLISHING AGENT; ADSORBENT; STABILIZER FOR PLASTICS; FOOD ADDITIVE AND DIETARY SUPPLEMENT.
It is used as anticaking agent for silicate-containing cleaning agents and table salt and as a stabilizer for CaHPO4.2H20.
Methods of Manufacturing
BY PRECIPITATION USING AQ SOLN OF TRIBASIC SODIUM PHOSPHATE AND MAGNESIUM SULFATE OR CHLORIDE. PRECIPITATE OF MAGNESIUM PHOSPHATE IS WASHED WITH WATER UNTIL...FREE OF SULFATE & THEN DRIED AT LOW TEMP.
REACTION OF MAGNESIUM OXIDE & PHOSPHORIC ACID @ HIGH TEMPERATURES.
Formulations/Preparations
TRIBASIC MAGNESIUM PHOSPHATE, NATIONAL FORMULARY. ORAL: POWDER. DRUG MARKETED UNDER GENERIC NAME.
Grades: technical, reagent, National Formulary (5 H2O variety), Food Chemical Codex (4, 5, or 8 H2O)
Use Classification
Food Additives -> ANTICAKING_AGENT -> JECFA Functional Classes
Food Additives -> ANTICAKING_AGENT -> JECFA Functional Classes
Food Additives -> ANTICAKING_AGENT -> JECFA Functional Classes
Cosmetics -> Opacifying; Anticaking; Bulking
Plastics -> Polymer Type -> N.a.
Plastics -> Pigments agents
General Manufacturing Information
Phosphoric acid, magnesium salt (2:3): ACTIVE
Phosphoric acid, magnesium salt (1:?): ACTIVE
BY-PRODUCT OF CELLULOSE & PAPER MANUFACTURED BY MAGNESIUM BISULFITE PROCESS. IT CONTAINS ABOUT 6% MAGNESIUM & 17% PHOSPHORIC ANHYDRIDE.
관련 반응
9건
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