티오황산 나트륨
티오황산염 · 나트륨산화물황화물(NA2S2O3) · 나트륨하이포아황산염 · 디나트륨티오황산염 · 나트륨티오황산염(NA2S2O3) · 나트륨티오황산염무수물 · 싸이오황산나트륨 · 티오황산(H2S2O3),디나트륨염
식별자 및 물리적 특성
| CAS No. | 7772-98-7 |
|---|---|
| 분자식 | Na2O3S2 |
| 평균 분자량 | 158.11 g/mol |
| 단동위원소 질량 | 157.90842442 g/mol |
| SMILES | O=S([O-])([O-])=S.[Na+].[Na+] |
| InChIKey | AKHNMLFCWUSKQB-UHFFFAOYSA-L |
| PubChem CID | 24477 |
| ChEMBL | CHEMBL2096650 |
| ChEBI | CHEBI:132112 |
| EC No. | 231-867-5 |
| DTXSID | DTXSID9042417 |
| 현지명 | 티오황산 나트륨 |
화학 및 물리적 성질
| 극성 표면적 | 104 |
|---|---|
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 4 |
| 회전 가능 결합 수 | 0 |
| 무거운 원자 수 | 7 |
| 형식 전하 | 0 |
| 복잡도 | 82.6 |
| 물질 분류 | Other Classes -> Sulfur Compounds |
| 화장품 | Reducing |
| LogP(분배 계수) | -4.35 (calculated) |
| 밀도 | 1.6671.7 g/cm³1.01 g/mL at 25 °C |
| Color/Form | POWDERCOLORLESS MONOCLINIC CRYSTALS |
| 용해도 | PRACTICALLY INSOL IN ALCOHOL50 G SOL IN 100 CC WATER231 G @ 100 °CSolubility in water, g/100ml at 20 °C: 20.9알코올과 혼합되지 않습니다. |
| Human Drugs | FDA approved drugs -> Active ingredientEMA approved medicines: Human medicineAntidotes and other substances used in poisonings > Specific |
| Animal Drugs | Pharmaceuticals -> UK Veterinary Medicines Directorate List |
| Decomposition | DANGEROUSWHEN HEATED TO DECOMP, THEY EMIT HIGHLY TOXIC FUMES OF /DISODIUM OXIDE AND SULFUR OXIDES/.300 °C |
| 녹는점 | 48.5 °C48°C |
| 증기압 | Vapor pressure at 20 °C: negligible |
| 굴절률 | INDEX OF REFRACTION: 1.489 ALPHA, 1.508 BETA, 1.536 GAMMAOPTIC SIGN + |
| 끓는 점 | 100°C |
| 저장 조건 | Store at +5°C to +30°C. |
| 물리적 상태 | 고체 |
| 비중 | 1.667 |
| 색상 | 하얀색 |
| pH | 6.0-8.5 (25℃, 50mg/mL in H2O) |
| 용해도 | 물에 용해됩니다. 알코올에 불용성. |
| Merck | 14,8694 |
| 안정성 | 안정적인. 강산, 강산화제, 요오드, 수은과 호환되지 않습니다. |
| 화장품 원료 기능 | 피부의 산화 스트레스를 줄이세요 |
| InChI | 1S/2Na.H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/q2*+1/p-2 |
| InChIKey | AKHNMLFCWUSKQB-UHFFFAOYSA-L |
| SMILES | [Na+].[Na+].[O-]S([O-])(=O)=S |
| LogP(분배 계수) | -0.428 (est) |
| EPA | Sodium thiosulfate (7772-98-7) |
화학적 성질
Sodium thiosulfate, Na2S203·5H20, also known as sodium hyposulfite, hypo,andsodium subsulfite, is a white crystalline solid that has a melting point of 48 °C(118 °F). Water soluble,it is used as a fixing agent for photographic films, plates, and papers. Sodium thiosulfate is used in medicine, as a germicide, in manufacturing leather, as a mordant in dyeing, and for extracting silver from ore.
안전 및 규제
| GHS 분류 | Not ClassifiedAggregated GHS information provided per 2963 reports by companies from 8 notifications to the ECHA C&L Inventory. |
|---|---|
| 규제 정보 | Chemical: Thiosulfuric acid (H2S2O3), disodium saltThiosulfuric acid (H2S2O3), sodium salt (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Thiosulfuric acid (H2S2O3), sodium salt (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 24-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14321Sodium thiosulphate: Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | IMAP assessments - Thiosulfuric acid (H2S2O3), disodium salt: Environment tier I assessment |
| 화재 위험 | Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of explosion on contact with oxidizing agents. |
| 유해성 요약 | Potential combustible dust hazardDecomposes slowly in water with potential generation of toxic and flammable hydrogen sulfide and corrosive hydrogen sulfite and sulfuric acidVery soluble in waterExtremely low vapor pressureMay violently decomposes at 223 deg C[CHEMINFO] ADI = 0-0.7 mg/kg[JECFA] May be used in food up to 0.1%[Hawley] See Potassium thiosulfate. |
| FDA 요건 | 121.101LIMITATIONS: GRAS, SEQUESTRANT IN SALT UP TO 0.1% |
| EPA Safer Chemical | Chemical: Sodium thiosulfate |
| Chemical Dangers | Decomposes on heating. This produces toxic fumes including sulfur oxides. Reacts violently with strong oxidants. |
| Hazard Classes and Categories | Not Classified |
| Explosive Limits and Potential | DRY TRITURATION WITH OXIDIZING AGENTS SUCH AS POTASSIUM CHLORATE, POTASSIUM PERMANGANATE, OR NITRATE MAY CAUSE EXPLOSION.WHEN SODIUM NITRITE & THIOSULFATE MIXT WAS HEATED TO EVAPORATE TO DRYNESS, VIOLENT EXPLOSION OCCURRED. |
| 소화 | In case of fire in the surroundings, use appropriate extinguishing media. |
| 응급 조치 | Fresh air, rest.Rinse and then wash skin with water and soap.Rinse with plenty of water for several minutes (remove contact lenses if easily possible).Rinse mouth. |
| 안전 보관 | Separated from strong oxidants. |
| 누출 처리 | Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. |
| Eye Prevention | Wear safety goggles. |
| Fire Prevention | NO contact with oxidizing agents. |
| Inhalation Risk | A nuisance-causing concentration of airborne particles can be reached quickly when dispersed. |
| Ingestion Prevention | Do not eat, drink, or smoke during work. |
| Inhalation Prevention | Avoid inhalation of dust. |
| Protective Action Criteria (PAC) | 5.8 [mg/m3]64 [mg/m3]380 [mg/m3] |
| Signs and Symptoms | Redness. |
| Human Toxicity Excerpts | REMARKABLY INERT IN VIVO, EXCEPT FOR OSMOTIC DISTURBANCES. ... ACTS AS OSMOTIC CATHARTIC. |
| Drug Induced Liver Injury | Drug Induced Liver Injury Rank (DILIrank 2.0)Sodium thiosulfatevNo-DILI-concernNo matchDOI:10.1016/j.drudis.2016.02.015 |
| 수질 위해 등급(WGK) | 1 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | XN6476000 |
| 독성 | LD50 orally in Rabbit: > 5000 mg/kg |
| 관세 코드 | 28323000 |
| 위험 문구(R) | 36/37/38 |
| 위험 표시 | Xi |
| 안전 문구(S) | 24/25-23-36-26 |
| 기존화학 물질 | KE-31633 |
| F 고인화성물질 | 3 |
| 저장 분류 | 11 - Combustible Solids |
| 유해 물질 데이터 | 7772-98-7(Hazardous Substances Data) |
용도
용도
각종 금속이온과 반응하여 티오 술파이트 착체를 생성하기 때문에 도금욕 중의 금속불순물 제거에 이용된다. 중금속이나 시안화수소의 해독제로써 사용된다. 수돗물의 염소제거제로 사용되기도 한다.
용도
Sodium thiosulfate is a common analytical reagent used in iodometric titration to analyze chlorine, bromine, and sulfide. Other uses are in bleaching paper pulp, bleaching straw, ivory, and bones, for removing chlorine from solutions, silver extraction from its ores, a mordant in dyeing and printing textiles, and as an antidote to cyanide poisoning. Another major application is in photography, where it is used as a fixer to dissolve unchanged silver salts from exposed negatives. Sodium Thiosulfate is used primarily as a medicament against cyanide poisoning, able to convert cyanide into thiocyanate, a reaction which is catalyzed by the enzyme Rhodanese. Antioxidant.
일반 설명
Sodium thiosulfate (Na2S2O3) can be obtained from Na2S2O3.10H2O by heating above 100 °C. It can be synthesized from sodium sulfate.
제조 및 합성 방법
제조 방법
Sodium thiosulfate is a common reducing agent. It reduces iodine to iodide anion forming sodium tetrathionate. This reaction is utilized in the so-called iodometric titration: 2S2O32ˉ + I2 → S4O62ˉ + 2IˉSodium thiosulfate reacts with chlorine to form sodium bisulfate and hydrochloric acid. This reaction removes chlorine from aqueous solutions:Na2S2O3 + 4Cl2 + 5H2O → 2NaHSO4 + 8HClSodium thiosulfate reacts with hydrochloric acid, decomposing to sulfur and sulfur dioxide: Na2S2O3 + 2HCl → 2NaCl + S + SO2 + H2O.