디메티콘

디메티콘 · 디메티콘(DIMETHICONE) · 디메티콘코폴리올 · 지메 · SILICONE FLUID · dimeticone · POLYMETHYLSILOXANE · DIMETHICONE 350

https://huagongshe.com/ko/chemical/24764

식별자 및 물리적 특성

CAS No.	107-46-0
분자식	C6H18OSi2
평균 분자량	162.38 g/mol
단동위원소 질량	162.08961826 g/mol
SMILES	C[Si](C)(C)O[Si](C)(C)C
InChIKey	UQEAIHBTYFGYIE-UHFFFAOYSA-N
PubChem CID	24764
ChEMBL	CHEMBL3184090
ChEBI	CHEBI:78002
EC No.	203-492-7
DTXSID	DTXSID4026769
현지명	디메티콘

화학 및 물리적 성질

극성 표면적	9.2
수소 결합 공여자 수	0
수소 결합 수용자 수	1
회전 가능 결합 수	2
무거운 원자 수	9
형식 전하	0
복잡도	76.2
물질 분류	Metals -> Metalloid Compounds (Silicon)
의약품	Pharmaceuticals
화장품	AntistaticEmollientSkin conditioningAntifoaming
SpringerMaterials Properties	29Si nuclear magnetic resonance spectrum
LogP(분배 계수)	log Kow = 4.2
밀도	0.7638 at 20 °C0.76 @ 20°C1 g/mL at 20 °C
Viscosity	0.51 centistokes at 20 °C
Color/Form	FLUID
용해도	In water, 0.93 mg/L at 25 °C0.93 mg/L @ 25 °C (exp)물에 거의 녹지 않으며 무수 에탄올에 거의 녹지 않거나 거의 녹지 않으며 에틸 아세테이트, 메틸 에틸 케톤 및 톨루엔과 혼합됩니다.
인화점	-30 °C121 °C
끓는 점	99 °C101 °C @760 [mm Hg]
Decomposition	When heated to decomposition it emits acrid smoke, fumes.
증기압	5 mm Hg ( 20 °C)
굴절률	n20/D 1.406
저장 조건	Refrigerator
색상	무색
안정성	안정적인. 타기 쉬운. 강한 산화제, 환원제, 유기물, 산, 알칼리와 호환되지 않습니다. 많은 금속을 부식시킵니다.
주요 응용	의약품(소분자)
화장품 원료 기능	소포제피부 보호피부 컨디셔닝 - 보습제피부 컨디셔닝
InChI	InChI=1S/C6H18OSi2/c1-8(2,3)7-9(4,5)6/h1-6H3
InChIKey	UQEAIHBTYFGYIE-UHFFFAOYSA-N
SMILES	O([Si](C)(C)C)[Si](C)(C)C
LogP(분배 계수)	3.646 (est)
EPA	Dimethicone (9006-65-9)

화학적 성질

Dimethicones are clear, colorless liquids available in various viscosities. Dimethicone is a fluid mixture of fully methylated linear siloxane polymers end-blocked with trimethylsiloxy units. Methicone is a linear monomethyl polysiloxane. Dimethicone are safe as used in cosmetic formulations, vulcanization.

안전 및 규제

GHS 분류	This chemical does not meet GHS hazard criteria for 0.1% (5 of 3584) of reports.DangerH225 (98.8%): Highly Flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P273, P280, P303+P361+P353, P370+P378, P391, P403+P235, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 3584 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
규제 정보	Chemical: Disiloxane, hexamethyl-Disiloxane, 1,1,1,3,3,3-hexamethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Disiloxane, 1,1,1,3,3,3-hexamethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 15-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15156Hexamethyldisiloxane: Does not have an individual approval but may be used under an appropriate group standard
기타 안전 정보	IMAP assessments - Disiloxane, hexamethyl-: Human health tier II assessment
유해성 요약	An eye irritantOral LD50 (rat) = >5000 mg/kg[HSDB] In a 28-day feeding study of rats, 8 mg/kg/day was the no toxic effect levelFood consumption was decreased and changes were seen in the liver and blood cells in animals fed 640 mg/kg/day[TSCA Sub-Acute Oral Toxicity Study in Rats] May cause irritation[MSDSonline]
Special Reports	European Chemicals BureauIUCLID Dataset, Hexamethyldisiloxane (107-46-0) (2000 CD-ROM edition). Available from the database query page: http://ecb.jrc.it/esis/esis.php as of July 31, 2006After the siloxanes class of chemicals was designated to the Interagency Testing Committee (ITC) Priority Testing List, an industry consortium, the Silicones Environmental, Health and Safety Council of North America (SEHSC), worked in cooperation with the ITC and the U.S. Environmental Protection Agency (EPA) to sponsor a voluntary health and safety program for siloxanes. Abstracts of each research report funded through SEHSC are posted under Siloxane Research Program on the SEHSC website [http://www.sehsc.com/srp-research-reports.asp]. The SEHSC also provides information on obtaining full copies of the reports from the EPA on this website.

용도

dimethicone is a form of silicone used to give products lubricity, slip, and good feel. It can also serve as a formulation defoamer and help reduce the feeling of greasiness that some creams leave on the skin immediately upon application. In addition, dimethicone is reported to protect the skin against moisture loss when used in larger quantities. It improves product flow and spreadability. In combination with other ingredients, dimethicone becomes a good waterproofing material for sunscreen emulsions, and helps reduce the greasiness often seen in high-SPF preparations.

제조 및 합성 방법

생산 방법

Dimethicone isapoly (dimethylsiloxane) obtained by hydrolysis and polycondensation of dichlorodimethylsilane and chlorotrimethylsilane. The hydrolysis products contain active silanol groups through which condensation polymerization proceeds. By varying the proportions of chlorotrimethylsilane, which acts as a chain terminator, silicones of varying molecular weight may be prepared. Different grades of dimethicone are produced that may be distinguished by a number placed after the name indicating the nominal viscosity. For example, ABIL 20 (Evonik Goldschmidt UK Ltd) has a nominal kinematic viscosity of 18–22mm2/s (18–22cSt).