부틸파바

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, you should dampen the solid spill material with alcohol, then transfer the dampened material to a suitable container. Use absorbent paper dampened with alcohol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminate area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

These agents /cholinesterase inhibitors such as antimyasthenics; cyclophosphamide; demecarium; echothiophate; neurotoxic insecticides, possibly including large quantities of topical malathion; isoflurophate; thiotepa/ may inhibit metabolism of ester derivatives; absorption of significant quantities of ester derivatives in patients receiving a cholinesterase inhibitor may lead to increased risk of toxicity. /Topical anesthetics/

Metabolites of PABA-derivative topical anesthetics may antagonize antibacterial activity of sulfonamides, especially if the anesthetics are absorbed in significant quantities over prolonged periods of time. /Topical anesthetics/

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

Used as a local anesthetic and in burn treatment ointments and suntan preparations; [Hawley] Used essentially 100% as a local anesthetic; [HSDB]

MEDICATION

MEDICATION (VET)

(1977) No Data

(1979) No Data

(1977) No Data

(1979) No Data

(1978) GREATER THAN 1.36X10+6 G (INCL PICRATE)

(1979) GREATER THAN 1.36X10+6 G (INCL PICRATE)

ESTERIFICATION OF P-NITROBENZOIC ACID WITH N-BUTYL ALCOHOL FOLLOWED BY REDUCTION WITH IRON FILINGS AND HYDROCHLORIC ACID

PREPARED BY ESTERIFYING P-NITROBENZOIC ACID WITH N-BUTYL ALCOHOL & REDUCING NITRO GROUP TO AMINO GROUP WITH IRON FILINGS & HCL.

Prepn: Brill, J. Am. Chem. Soic. 43, 1322 (1921); Adams, Volwiler, U.S. pat 1,440,652 (1923 to Abbott); Brit. pat. 252,870; C.A. 17, 1243 (1923); C.A. 21, 2478 (1927).

Produced by the esterification of 4-nitrobenzoyl chloride with n-butanol and reduction of the resulting nitroester.

... MAY BE APPLIED AS DUSTING POWDERS, UNDIL OR DIL WITH STERILE TALC. THEY ARE SOL IN OIL & MAY BE INC IN OILY SOLN, OINTMENTS, & SUPPOSITORIES. /ANESTHETICS OF LOW SOLUBILITY/

Grade: NF

Benzoic acid, 4-amino-, butyl ester: ACTIVE

Available in the United States as a surface anesthetic in the form of a picrate.