Butenafine

But·Nafine · BUTENAFINE · Butenafine USP/EP/BP · 4-tert-Butylbenzylmethyl 1-naphtylmethylamine · (4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine · N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine · N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine · n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine

https://huagongshe.com/ko/chemical/2484

식별자 및 물리적 특성

CAS No.	101828-21-1
분자식	C23H27N
평균 분자량	317.5 g/mol
단동위원소 질량	317.21434987 g/mol
SMILES	CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12
InChIKey	ABJKWBDEJIDSJZ-UHFFFAOYSA-N
PubChem CID	2484
ChEMBL	CHEMBL990
ChEBI	CHEBI:3238
DTXSID	DTXSID7040657

화학 및 물리적 성질

XLogP	6.3
극성 표면적	3.2
수소 결합 공여자 수	0
수소 결합 수용자 수	1
회전 가능 결합 수	5
무거운 원자 수	24
형식 전하	0
복잡도	374
LogP(분배 계수)	6.6
용해도	Slightly soluble (HCl salt)7.56e-05 g/LDMSO: 63 mg/mL (198.44 mM)Ethanol: 63 mg/mL (198.44 mM)
Physical Description	Solid
녹는점	200-202 °C
끓는 점	426.1±14.0 °C(Predicted)
밀도	1.032±0.06 g/cm3(Predicted)
저장 조건	Store at -20°C
pKa(산도 계수)	7.87±0.50(Predicted)
용해도	Water: Insoluble
LogP(분배 계수)	6.770 (est)

안전 및 규제

Effects During Pregnancy and Lactation	◉ Summary of Use during LactationTopical butenafine has not been studied during breastfeeding. Because it is poorly absorbed after topical application, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.◉ Effects in Breastfed InfantsRelevant published information was not found as of the revision date.◉ Effects on Lactation and Breastmilk

Effects During Pregnancy and Lactation

◉ Summary of Use during LactationTopical butenafine has not been studied during breastfeeding. Because it is poorly absorbed after topical application, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.◉ Effects in Breastfed InfantsRelevant published information was not found as of the revision date.◉ Effects on Lactation and Breastmilk

용도

Butenafine (Mentax) is a synthetic benzylamine antifungal agent, related structurally and pharmacologically to terbinafine. It is thought to act by inhibiting the enzyme squalene 2,3-epoxidase, resulting in decreased ergosterol and corresponding increase in squalene, with subsequent cell membrane permeability alteration and cell death. It is active against dermatophytes, yeast, and Sporothrix.