Ferric Phosphate

Plastics -> Pigments agents

Plastics -> N.a.

Agrochemicals -> Pesticide active substances

Active substance -> EU Pesticides database: Approved

White, grayish-white, or light pink, orthorhombic or monoclinic crystals or amorphous powder. Loses water above 140 °C; density: 2.8. Practically insoluble in water; readily soluble in hydrochloric acid; slowly soluble in nitric acid. /Dihydrate/

2.87 @25 °C

Dry Powder; Large Crystals

Dihydrate: White, grayish-white, or light-pink solid, practically insoluble in water; Loses water above 140 deg C; [Merck Index] Whitish odorless crystals or powder; [MSDSonline]

This chemical does not meet GHS hazard criteria for 59.4% (142 of 239) of all reports.

Warning

H315 (20.9%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 239 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

Chemical: Phosphoric acid, iron(3+) salt (1:1)

Commission Regulation (EU) No 1141/2010

Phosphoric acid, iron(3+) salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphoric acid, iron(3+) salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

01/87/EC, Reg. (EU) 2015/1166, Reg. (EU) No 540/2011

REACH registered substance: Iron orthophosphate (EC: 233-149-7)

Iron (III) phosphate: Does not have an individual approval but may be used under an appropriate group standard

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Trace minerals added to animal feeds. These substances added to animal feeds as nutritional dietary supplements are generally recognized as safe when added at levels consistent with good feeding practice. All substances listed may be in anhydrous or hydrated form. Iron phosphate is included on this list. /Iron Phosphate/

Ferric phosphate used as a nutrient and/or dietary supplement in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

New Active Ingredients ... includes pesticide active ingredients initially registered after November 1, 1984, that currently have active product registrations. By law, these newer pesticides are not subject to the reregistration program. They must, however, meet the new safety standard of the FQPA, and will be reviewed on a 15-year cycle under the registration review program. ... Active Ingredient Number: 034903; Type of Pesticide: biopesticide- insecticide/molluscicide; Use Site: food; Year: 1997.

An exemption from the requirement of a tolerance is established for residues of the biochemical pesticide, ferric phosphate in or on all food commodities.

Skin Irrit. 2 (20.9%)

Skin Irrit. 2 (100%)

Inhalation of ferric salts as dusts and mists is irritating to the respiratory tract. Ferric salts are regarded as skin irritants. /Iron salts/

If inhaled, iron is a local irritant to the lung and gastrointestinal tract. /Iron compounds/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

The following wastewater treatment technologies have been investigated for iron (Fe+2): Concentration process: Biological treatment. /Iron (Fe+2)/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

All ... /iron/ preparations should be kept in child-proof bottles. /Iron preparations/

5.4 [mg/m3]

59 [mg/m3]

360 [mg/m3]

Australia, Belgium, Finland, Italy, Netherlands, & Switzerland: 1 mg/cu m. /Iron salts/

Australia (1978); Belgium (1978); Finland (1975); Italy (1978); Netherlands (1978); and Switzerland (1978): 1 mg/cu m. /From table/ /Ferric salts, as Fe/

Occurs in nature as the minerals: beraunite, cacoxenite, dufrenite, koninckite, phosphosiderite, strengite.

...In small quantities in practically all phosphate rock and in rather large quantities in some of lower grades of rock.

/GENOTOXICITY/ A number of ferrous and ferric salts have been tested for mutagenicity using the following organisms. Saccharomyces cerevisiae strain D-4, Salmonella typhimurium strains. TA-1535, TA-1537, and TA-1538 with and without activation. Plate tests as well as suspension tests were run with the Salmonella strains. ...Ferric orthophosphate... /was/ inactive in all the systems used.

/GENOTOXICITY/ The mutagenic activity of elemental and salt forms of iron (Fe), including compounds currently being used in dietary supplements and for food fortification, were evaluated for mutagenicity in Salmonella typhimurium and L5178Y mouse lymphoma cells. Except for the weak response obtained with ferrous fumarate, none of the compounds induced a mutagenic response in Salmonella. In the mouse lymphoma assay, responses were related to the Fe compound and/or reduction of ferric (Fe+3) to ferrous (Fe+2). Responses with the elemental forms of Fe were divergent. Electrolytic Fe with a relatively larger particle size and irregular shape was negative. The smaller-sized carbonyl Fe, which after 4 hr attached to and was taken up by the cells, induced mutagenic responses both with and without S9. With ferric chloride (FeCl3) and ferric phosphate (FePO4), there was an increase in mutant frequency only with S9. With the Fe+2 compounds, ferrous sulfate (FeSO4) and ferrous fumarate (FeC4H2O4), positive responses were observed without S9. The Fe chelate, sodium Fe(III)EDTA was positive in both the presence and absence of S9. The lowest effective doses (LED) for induction of mutagenicity were identified for these compounds and an LED ratio calculated. The LED ratio ranges from 1 for FeSO4 to 30 for carbonyl Fe, which are similar to oral LD50 values obtained in animal studies.

/ALTERNATIVE IN VITRO TESTS/ ...Guinea-pig exudate cells were cultured with varying concentrations of the dusts of interest. The end point was defined as the smallest concentration of dust required to reduce the number of cells to <10% of the inoculum within 3 days. ...Ferric-phosphate were tested at concentrations up to 120 ug)/1,000,000 cells. ...Ferric-phosphate had negligible effects on cultures.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. /Iron and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with lactated Ringer's /SRP: "To keep open", minimal flow rate/. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Iron and related compounds/

Maintain an open airway and assist ventilation if necessary. Treat shock caused by hemorrhagic gastrointestinitis aggressively with intravenous crystalloid fluids, and replace blood if needed. Patients are often markedly hypovolemic owing to gastrointestinal losses and third spacing of fluids into the intestinal wall and interstitial space. Treat coma, seizures, and metabolic acidosis if they occur. For seriously intoxicated victims (eg, shock, severe acidosis, and/or serum iron > 500-600 mcg/dL) administer deferoxamine. Monitor the urine for the urine for the characteristic orange or pink deferoxamine-iron complex. Therapy may be stopped when the urine returns to normal or when the serum iron level decreases to the normal range. Prolonged deferoxamine has been associated with adult respiratory distress syndrome and Yersinia sepsis.

Activated charcoal is not effective. Ipecac is not recommended, because it can aggravate iron-induced gastrointestinal irritation and interfere with whole bowel irrigation. Consider gastric lavage if product was a liquid formulation or tablets were chewed. Do-not use phosphate-containing solutions for lavage; these may result in life-threatening hypernatremia, hyperphosphatemia, and hypocalcemia. Bicarbonate and deferoxamine lavage are of doubtful efficacy. Deferoxamine lavage is not effective and may enhance iron absorption. Whole-bowel irrigation is very effective for ingested tablets and may be considered first-line treatment, especially if large numbers of tablets are visible on plain abdominal x-ray. Massive ingestions may lead to concretions or bezoars. Repeated or prolonged whole-bowel irrigation may remove tablets. Endoscopy or surgical gastrotomy is rarely required.

Hemodialysis and hemoperfusion are not effective for removing iron but may be necessary to remove iron-deferoxamine complex in patients with renal failure. Exchange transfusion is occasionally used for massive pediatric ingestions but is of questionable efficacy.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

Trace minerals added to animal feeds. These substances added to animal feeds as nutritional dietary supplements are generally recognized as safe when added at levels consistent with good feeding practice. All substances listed may be in anhydrous or hydrated form. Iron phosphate is included on this list. /Iron Phosphate/

Ferric phosphate used as a nutrient and/or dietary supplement in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

New Active Ingredients ... includes pesticide active ingredients initially registered after November 1, 1984, that currently have active product registrations. By law, these newer pesticides are not subject to the reregistration program. They must, however, meet the new safety standard of the FQPA, and will be reviewed on a 15-year cycle under the registration review program. ... Active Ingredient Number: 034903; Type of Pesticide: biopesticide- insecticide/molluscicide; Use Site: food; Year: 1997.

An exemption from the requirement of a tolerance is established for residues of the biochemical pesticide, ferric phosphate in or on all food commodities.

..Weanling male rats were made anemic by feeding a semipurified diet containing 8.4 mg iron/kg, and by bleeding. They were divided into 9 groups so that hemoglobin levels and body weights were similar. The rats were fed the basal diet or basal diet plus 12, 24, 36 and 48 mg iron/kg diet provided as ferrous sulfate or ferric orthophosphate. The rats were fed 10 g daily of the respective diets for 10 consecutive days. The efficiency of the conversion of dietary iron into hemoglobin iron was not significantly affected by dietary level of either iron salt. It was determined that ferric orthophosphate was 51% as efficient as ferrous sulfate for hemoglobin regeneration in the anemic rat.

Eight laboratories conducted a hemoglobin repletion test for the estimation of the bioavailability of iron from 4 sources, using depleted male albino rats. Ferrous sulfate was used as the reference standard. Ferric orthophosphate was found to have a relative biological value of 11 (range 6-22), an old sample of hydrogen-reduced iron 27 (range 15-41), and ferric citrate 96 (range 75-125). Good results were obtained with a simplified basal diet prepared without ingredients that had previously contributed variable quantities of iron. There was no apparent advantage in using the change in hemoglobin during the repletion period instead of the final hemoglobin value as the criterion of response to iron supplements. Several statistical treatments of the data yielded similar conclusions regarding relative biological values of the iron sources.

Used in food and feed supplements (particularly in bread), in fertilizers, and as a pesticide for control of snails and slugs; [HSDB]

Farming (Feed Additives) [Category: Industry]

For ferric phosphate (USEPA/OPP Pesticide Code: 034903) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Food and feed supplement, particularly in bread enrichment; as fertilizer /Dihydrate/

As a pesticide active ingredient, iron phosphate is used in controlling snails and slugs on food crops and ornamentals at outdoor and indoor sites.

Catalysts, pigments, drugs, agriculture, nutrition, metallurgy, and leather tanning. /Iron compounds/

Information on 8 consumer products that contain Ferric phosphate in the following categories is provided:

Information on 2 consumer products that contain Ferric phosphate in the following categories is provided:

Plastics -> Polymer Type -> N.a.

Plastics -> Pigments agents

Synthetic Dye and Pigment Manufacturing

Phosphoric acid, iron(3+) salt (1:1): ACTIVE

Phosphoric acid, iron salt (1:?): ACTIVE

A nutrient and/or dietary supplement food additive. Also used as trace mineral added to animal feeds.

As feed source of iron (even in bread for man), particularly in mineral mixes.

Small quantities ... used as iron-enrichment compound in food applications. ... Although it is insoluble in water, it is soluble to varying degrees in dilute hydrochloric-acid solutions, such as those in the stomach. The degree of solubility can be controlled by the method of mfr.