Cadralazine

HCID 2515CAS 64241-34-5
부분 구조 검색유사 구조 찾기

기본 정보

표준 SMILES
CCOC(=O)NNc1ccc(N(CC)CC(C)O)nn1
InChIKey
QLTVVOATEHFXLT-UHFFFAOYSA-N
분자식
C12H21N5O3
평균 분자량
283.33 g/mol
단동위원소 질량
283.16443953

개요

Cadralazine is an organic molecular entity.

이름 및 식별자

우선 이름
Cadralazine
IUPAC
ethyl N-[[6-[ethyl(2-hydroxypropyl)amino]pyridazin-3-yl]amino]carbamate
영어명
Cadralazine
분자식
C12H21N5O3
분자량
283.33

이름 및 동의어

cadralazine64241-34-5CadralCadralazinaCadralazinumDTXSID4048725Ethyl 6-(ethyl(2-hydroxypropyl)amino)-3-pyridazinecarbazate8T96I3U713DTXCID1028651N-(6-(ethyl(2-hydroxypropyl)amino)pyridazin-3-yl)ethoxycarbohydrazonic acidN-{6-[ethyl(2-hydroxypropyl)amino]pyridazin-3-yl}ethoxycarbohydrazonic acidRefChem:573306
이름 더 보기
DC-26DC 826ISF-469PresmodeISF 2469CGP 18684E
C02DB04Ethyl 3-(6-(ethyl((2RS)-2-hydroxypropyl)amino)pyridazin-3-yl)carbazateethyl N-[[6-[ethyl(2-hydroxypropyl)amino]pyridazin-3-yl]amino]carbamateethyl 2-(6-(ethyl(2-hydroxypropyl)amino)pyridazin-3-yl)hydrazine-1-carboxylateHydrazinecarboxylic acid, 2-[6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]-, ethyl esterNCGC00182063-02CadratenCadrilan

데이터베이스 식별자

CAS
64241-34-5
PubChem CID
2515
DTXSID
DTXSID4048725
ChEMBL
CHEMBL2106561
ChEBI
CHEBI:31331
UNII
8T96I3U713
Nikkaji
J69.473H

물성

구조 계산 물성

XLogP
1
극성 표면적
99.6 Ų
수소 결합 공여자 수
3
수소 결합 수용자 수
7
회전 가능 결합 수
8
무거운 원자 수
20

물리화학적 성질

녹는점
160 · 160-162°
끓는 점
425.88 °C · 425.88°C (rough estimate)
밀도
1.1585 · 1.1585 (rough estimate)
굴절률
1.65 · 1.6500 (estimate)
저장 조건
2 · 2-8°C
용해도
250 mg/mL · DMSO : 250 mg/mL (882.36 mM; ultrasonic and warming and heat to 60°C)

안전 및 규제

안전 데이터

독성
LD50 in rats, dogs (mg/kg): 269, approx 400 i.v.; 2060, >2000 orally (Semeraro); in mice (mg/kg): 700 i.p. (Parravicini)

화학 및 산업

약리 정보

ATC Code · 2건

C - Cardiovascular system

QC - Cardiovascular system

MeSH Pharmacological Classification · 2건

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Drugs used to cause dilation of the blood vessels.

Cellular LocationsMembrane

응용 분야

개요Cadralazine is a vasodilatory antihypertensive reportedly better-tolerated and longer-acting than hydralazine. It is useful as a second-line treatment in the management of hypertension.

상·하류 제품 정보

공급사29 곳

沈阳中申泽康生物医学技术研究有限公司024-88590548 18698872706 · [email protected]
苏州启航生物科技有限公司18151111370 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]

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