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테트라제팜

Tetrazepam

HCID 25215
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
10379-14-3
표준 SMILES
CN1C(=O)CN=C(C2=CCCCC2)c2cc(Cl)ccc21
InChIKey
IQWYAQCHYZHJOS-UHFFFAOYSA-N
분자식
C16H17ClN2O
평균 분자량
288.77 g/mol
단동위원소 질량
288.1029409

개요

Tetrazepam is a benzodiazepine.

이름 및 식별자

우선 이름
Tetrazepam
IUPAC
7-chloro-5-(cyclohexen-1-yl)-1-methyl-3H-1,4-benzodiazepin-2-one
현지명
테트라제팜
영어명
TETRAZEPAM
분자식
C16H17ClN2O
분자량
288.77

이름 및 동의어

TetrazepamMyolastanMusarilClinoxan10379-14-3CB 4261CB-4261FO92091VP8DTXSID001460587-chloro-5-(cyclohex-1-en-1-yl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one7-chloro-5-(1-cyclohexen-1-yl)-1,3-dihydro-1-methyl-2h-1,4-benzodiazepin-2-oneRefChem:188914
이름 더 보기
테트라제팜epineCS-3124261cb4361cbcb42614361 CB
DTXCID8068549233-837-7Ro 06-66574261 CB7-Chloro-5-(cyclohexen-1-yl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one2H-1,4-BENZODIAZEPIN-2-ONE, 7-CHLORO-5-(1-CYCLOHEXEN-1-YL)-1,3-DIHYDRO-1-METHYL-Tetrazepam (INN)7-Chloro-5-(1-cyclohexenyl)-1-methyl-2-oxo-2,3-dihydro-1H-(1,4)-benzo(f)diazepine

데이터베이스 식별자

CAS
10379-14-3
PubChem CID
25215
DTXSID
DTXSID00146058
ChEMBL
CHEMBL2105527
ChEBI
CHEBI:135198
UNII
FO92091VP8

물성

구조 계산 물성

XLogP
3.2
극성 표면적
32.7 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
2
회전 가능 결합 수
1
무거운 원자 수
20
형식 전하
0
복잡도
457

실험 및 물리화학적 성질

Drugs · 5건

DEA NFLIS-Drug Category -> Benzodiazepines

DEA Schedule IV Controlled Substance -> Depressants

Pharmaceuticals

Pharmaceuticals -> Benzodiazepines

Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds

LogP · 2건

3.20

2.76

Melting Point144 °C
Physical DescriptionSolid

물리화학적 성질

녹는점
144 ° · 144°
끓는 점
502.1 · 502.1±50.0 °C(Predicted)
밀도
1.1741 · 1.1741 (rough estimate)
굴절률
1.58 · 1.5800 (estimate)
용해도
물에 거의 녹지 않으며, 염화메틸렌에 잘 녹고, 아세토니트릴에 녹습니다.
산도 계수 (pKa)
4.1 · 4.10±0.10(Predicted)

화학적 성질

Light yellow or yellow crystalline powder.

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 4건

Danger

H301 (40%): Toxic if swallowed [Danger Acute toxicity, oral]

P203, P261, P262, P264, P270, P271, P272, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P316, P318, P319, P321, P330, P333+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 5 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 2건

DEA schedule IV controlled substance

2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(1-cyclohexen-1-yl)-1,3-dihydro-1-methyl-: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesAcute Tox. 3 (40%)

독성 정보

Treatment · 1건

General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of norepinephrine or metaraminol. Dialysis is of limited value. Flumazenil (Anexate) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. In particular, flumazenil is very effective at reversing the CNS depression associated with benzodiazepines but is less effective at reversing respiratory depression. Its use, however, is controversial as it has numerous contraindications. It is contraindicated in patients who are on long-term benzodiazepines, those who have ingested a substance that lowers the seizure threshold, or in patients who have tachycardia or a history of seizures. As a general rule, medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. Although benzodiazepines are absorbed by activated charcoal, gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse effects often outweigh any potential benefit from the procedure. It is recommended only if benzodiazepines have been taken in combination with other drugs that may benefit from decontamination. Gastric lavage (stomach pumping) or whole bowel irrigation are also not recommended.

화학 및 산업

약리 정보

ATC Code · 2건

M - Musculo-skeletal system

QM - Musculo-skeletal system

MeSH Pharmacological Classification · 1건

A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)

Cellular LocationsMembrane

용도 및 제조

Uses · 2건

Use (kg; approx.) in Germany (2009): >2500

Tetrazepam is used to treat muscle spasm, anxiety disorders such as panic attacks, or more rarely to treat depression, premenstrual syndrome or agoraphobia.

응용 분야

용도Tetrazepam is a muscle relaxant (skeletal). This is a controlled substance (depressant).

관련 반응

0건
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화합물 노트

불러오는 중…

이 페이지에서기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
EC Number
233-837-7
Nikkaji
J10.468J
Toxicity Summary · 1건

Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Drug Induced Liver Injury · 4건

Drug-Induced Liver Injury Severity and Toxicity (DILIst)

Tetrazepam

DILI Positive

DOI:10.1016/j.drudis.2019.09.022

안전 데이터

독성
LD50 in mice (mg/kg): 415 i.p.; 2000 orally (Schmitt)
DEA Controlled Substances
CSCN: 2886CSA SCH: Schedule IVNARC: No