키스펩틴-10
키스펩틴-10 · KISSPEPTIN-10 · Kisspetin-10 · Kisspeptin-10 Fragment · METASTIN (45-54) · Kisspeptin-10 acetate · KiSS-1 · KISS-10
식별자 및 물리적 특성
| CAS No. | 374675-21-5 |
|---|---|
| 분자식 | C63H83N17O14 |
| 평균 분자량 | 1,302.4 g/mol |
| 단동위원소 질량 | 1,301.63054039 g/mol |
| SMILES | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |
| InChIKey | RITKWYDZSSQNJI-INXYWQKQSA-N |
| PubChem CID | 25240297 |
| ChEMBL | CHEMBL376756 |
| 현지명 | 키스펩틴-10 |
화학 및 물리적 성질
| XLogP | -1.9 |
|---|---|
| 극성 표면적 | 538 |
| 수소 결합 공여자 수 | 18 |
| 수소 결합 수용자 수 | 16 |
| 회전 가능 결합 수 | 38 |
| 무거운 원자 수 | 94 |
| 형식 전하 | 0 |
| 복잡도 | 2,590 |
| 밀도 | 1.46±0.1 g/cm3(Predicted) |
| 저장 조건 | -20°C |
| 용해도 | DMF: 15 mg/mlDMSO: 15 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml |
| 물리적 상태 | 결정성 고체 |
| pKa(산도 계수) | 9.96±0.15(Predicted) |
| 색상 | White to off-white |
| 용해도 | 1mg/ml로 물에 용해됨 |
| InChIKey | RITKWYDZSSQNJI-INXYWQKQSA-N |
안전 및 규제
| 수질 위해 등급(WGK) | 3 |
|---|---|
| 저장 분류 | 11 - Combustible Solids |
용도
개요
Kisspeptin-10, also called Metastin (45-54), is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.
용도
Kisspeptin 10 (human) is a powerful and specific activator for AXOR12 and hOT7T175 receptors. The Kisspeptin 10 (human) amide has been utilized in studies involving progesterone release from MA-10 cells and in experiments to induce gonadal differentiation in clownfish.
용도
Kisspeptin-10 (human), a member of the kisspeptin family, is a neuropeptide that regulates gonadotropin secretion. It has anti-angiogenic effects, a concentration-dependent inhibition of HUVEC proliferation and migration, and is highly expressed in the placenta, which may help to regulate angiogenesis in this tissue. Kisspeptin-10 (human) is currently undergoing clinical studies with insulin secretion in men. It is also a potential drug target for the treatment of infertility.
일반 설명
Metastin is also known as kisspeptin 1 (KISS1). It is encoded by KISS1 gene, that is mapped to human chromosome 1q32. Metastin is a tumor suppressor protein, made up of 145 amino acids. The protein fragments contain RFamide motif at the C- terminal end. The encoded protein is expressed in the human hypothalamus, gonads, placenta, liver and pancreas. This novelpeptideis mainly isolated from the human placenta.