홈MCP워크벤치Skills
홈워크벤치알림마이페이지
Huagongshe 오픈 프로젝트：[email protected]AI 접속: llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.7.8
돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HCID 25429생성일: 2026년 10월 27일

카벤다짐

카벤다딘 · 메틸-N-(2-벤즈이미다조릴)카바메이트 · 카벤다짐 · 프리벤톨BCM · 카벤다짐(CARBENDAZIM) · 카르벤다짐 · BCM · MBC

https://huagongshe.com/ko/chemical/25429

카벤다짐 분자 구조식

식별자 및 물리적 특성

CAS No.10605-21-7
분자식C9H9N3O2
평균 분자량191.19 g/mol
단동위원소 질량191.06947653 g/mol
SMILESCOC(=O)Nc1nc2ccccc2[nH]1
InChIKeyTWFZGCMQGLPBSX-UHFFFAOYSA-N
PubChem CID25429
ChEMBLCHEMBL70971
ChEBICHEBI:3392
EC No.234-232-0
DTXSIDDTXSID4024729
현지명카벤다짐

화학 및 물리적 성질

XLogP1.5
극성 표면적67
수소 결합 공여자 수2
수소 결합 수용자 수3
회전 가능 결합 수2
무거운 원자 수14
형식 전하0
복잡도222
의약품Pharmaceuticals -> Listed in ZINC15
농약Agrochemicals -> Pesticide active substancesActive substance -> EU Pesticides database: Not approvedPesticides -> FungicidesEnvironmental transformation -> Pesticides (parent, predecessor)Pesticides -> Fungicides -> Benzimidazole fungicidesFungicides, Transformation products
LogP(분배 계수)log Kow = 1.521.491.75
냄새Odorless /Technical/
밀도1.45 at 68 °F (NTP, 1992) - Denser than waterwill sink1.45 g/cu cm at 25 °C0.27 g/cm³1.4500
Color/FormWhite powderCrystalline powderNearly white solid /Technical/Light-gray powderOff-white, crystalline powder
용해도less than 1 mg/mL at 70 °F (NTP, 1992)Solubility in water at 24 °C: 29 mg/L at pH 48 mg/L at pH 71.49 mg/L at pH 8Soluble in (g/L at 24 °C): dimethylformamide 5, acetone 0.3, ethanol 0.3, chloroform 0.1, ehtyl acetate 0.135, dichlormethane 0.068, benzene 0.036, cyclohexane <0.01, diethyl ether <0.01, hexane 0.0005Xylene: <1 g/100 g at 20 °CCylcohexanone: < 1 g/100 g /Technical grade/Solubility at 20 °C (mg/L): hexane 0.5benzene 36dichloromethane 68ethanol 300dimethylformamide 5000, chloroform 100, acetone 300Slightly soluble in most solvents피리딘: 가용성 1%, 투명하고 매우 희미한 갈색을 띤 노란색
Endocrine DisruptorsPotential endocrine disrupting compound
DecompositionDecomposes at 300 °C.When heated to decomposition it emits toxic fumes of /nitric oxides/.Slowly decomposed in alkaline soln (22 °C): DT50 >350 days (pH 5 and pH 7), 124 days (pH 9).302-307 °C
녹는점576 to 585 °F (decomposes) (NTP, 1992)Decomposes at 300 °CMP: 302-307 °C (decomposes)302 - 307 °C>300 °C (lit.)
증기압less than 0.000000075 mmHg at 68 °F<0.001 mmHg at 257 °F (NTP, 1992)7.5X10-10 mm Hg at 20 °CVapor pressure at 20 °C: negligible1.5 x 10-4 Pa (25 °C)
Physical DescriptionCarbendazim appears as light gray or beige powder. (NTP, 1992)White to light-gray, odorless solid[HSDB] Powder[MSDSonline]COLOURLESS CRYSTALS OR GREY-TO-WHITE POWDER.
끓는 점326.92°C (rough estimate)
굴절률1.6500 (estimate)
인화점11 °C
저장 조건-20°C
pKa(산도 계수)4.48(at 25℃)
물리적 상태Solid
색상White to off-white
생물학적 소스human
용해도21°C에서 <0.1g/100mL
Merck13,1799
BRN649044
헨리 상수4.7×105 mol/(m3Pa) at 25℃, HSDB (2015)
주요 응용농업청소용품화장품환경음식 및 음료개인 위생 관리
InChI1S/C9H9N3O2/c1-14-9(13)12-8-10-6-4-2-3-5-7(6)11-8/h2-5H,1H3,(H2,10,11,12,13)
InChIKeyTWFZGCMQGLPBSX-UHFFFAOYSA-N
SMILESCOC(=O)Nc1nc2ccccc2[nH]1
LogP(분배 계수)1.4-1.5 at 25℃ and pH5-9
EPACarbendazim (10605-21-7)

안전 및 규제

GHS 분류DangerH317: May cause an allergic skin reaction [Warning Sensitization, Skin]P203, P261, P272, P273, P280, P302+P352, P318, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.3% (2 of 692) of reports.H317 (27.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]
규제 정보Chemical: Carbamic acid, 1H-benzimidazol-2-yl-, methyl esterHazard Traits - GenotoxicityReproductive ToxicityRegulation (EC) No 396/2005 (amended)Carbendazim (MBC) is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)2006/135/EC, 2010/70/EC, 2011/58/EU, Reg (EU) 2015/408, Reg. (EU) 2022/801, Reg. (EU) No 540/2011, Reg. (EU) No 542/2011Status: Active Update: 04-03-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/27856
기타 안전 정보IMAP assessments - Carbamic acid, 1H-benzimidazol-2-yl-, methyl ester: Human health tier II assessment
운송 라벨(DOT)Class 9
화재 위험Literature sources indicate that this chemical is probably nonflammable. (NTP, 1992)Gives off irritating or toxic fumes (or gases) in a fire.
건강 유해성ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of NOx. (NTP, 1992)
유해성 요약Reproductive toxin in animal studies[ICSC] Toxic by ingestion and skin absorptionWorkers may be exposed after inhalation of dust or skin contactMale rats fed 200 mg/kg 5 days/week for 2 weeks have testicular damageRats fed 32 mg/kg for 90 days have liver and kidney damage[HSDB] An irritant[MSDSonline] Induces genetic damage in germ cells of humans or animals (3A)[MAK]
반응성 그룹Amines, Phosphines, and Pyridines
EC 분류Symbol: T, N

용도

개요

Carbendazim is the degradation product and active ingredient of the carbamate fungicide benomyl. Carbendazim (100 μM) disrupts the growth of S. cerevisiae by inhibiting microtubule polymerization. It impairs meiosis and steroidogenesis in an ex vivo rat model of seminiferous tubules and increases prostate weight in rats when administered at a dose of 100 mg/kg but does not affect other testosterone-dependent or estrogen-dependent tissues.

용도

Carbendazim is the most widely used active ingredient in the benzimidazole class of fungicides. It is a systemic fungicide with both protective and curative activities against a wide range of fungal diseases, especially caused by most Ascomycetes spp. and some Basidiomycetes and Deuteromycetes spp. in a wide variety of crop and ornamental uses.

일반 설명

Light gray or beige powder.

R: 46-60-61-50/53
S: 53-45-60-61
RCRA 요건U372As stipulated in 40 CFR 261.33, when carbendazim, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).
FIFRA 요건New Active Ingredients ... includes pesticide active ingredients initially registered after November 1, 1984, that currently have active product registrations. By law, these newer pesticides are not subject to the reregistration program. They must, however, meet the new safety standard of the FQPA, and will be reviewed on a 15-year cycle under the registration review program. ... Active Ingredient Number: 128872Type of Pesticide: fungicideUse Site: non-food use.
Reactivity ProfileCARBENDAZIM is a carbamate ester-amine. Amines behave as chemical bases. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.
Chemical DangersDecomposes slowly on contact with bases.
소화Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)Use water spray, powder.
응급 조치Fresh air, rest.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Rest.
응급 처치EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.
안전 보관Separated from bases and food and feedstuffs.
노출 관리 및 개인 보호10.0 [mg/m3], inhalable fraction[German Research Foundation (DFG)]
소화 절차Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.
보관 조건Keep container tightly closed in a dry and well-ventilated place.
정리 방법ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures. Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
비화재 누출 대응SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
처리 방법Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number U372, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubberContaminated packaging: Dispose of as unused product.Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
누출 처리Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Preventive MeasuresACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures. Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.Precautions for safe handling: Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.
TreatmentFor acute exposures and first aid: EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.
상호 작용... The present work studied the effect of licorice aqueous extract on carbendazim-induced testicular toxicity in albino rats. Administration of carbendazim induced significant decrease in testis weight, diameter, and germinal epithelial height of the seminiferous tubules. Histological results revealed degeneration of seminiferous tubules, loss of spermatogenic cells, and apoptosis. Moreover, carbendazim caused elevation of testicular malondialdehyde (MDA), marker of lipid peroxidation, and reduced the activity of the antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Coadministration of licorice extract with carbendazim improved the histomorphological and histopathological changes observed in animals treated with carbendazim. In addition, licorice treatment leads to a significant decrease in the level of MDA and increase in the activities of SOD and CAT. According to the present results, it is concluded that licorice aqueous extract can improve the testicular toxicity of carbendazim and this effect may be attributed to antioxidant properties of one or more of its constituents.2,5-Hexanedione (2,5-HD), a taxol-like promoter of microtubule assembly, and carbendazim (CBZ), a colchicine-like inhibitor of microtubule assembly, are two environmental testicular toxicants that target and disrupt microtubule function in Sertoli cells. At the molecular level, these two toxicants have opposite effects on microtubule assembly, yet they share the common physiologic effect of inhibiting microtubule-dependent functions of Sertoli cells. By studying a combined exposure to 2,5-HD and CBZ, we sought to determine whether CBZ would antagonize or exacerbate the effects of an initial 2,5-HD exposure. In vitro, 2,5-HD-treated tubulin had a decreased lag time and an increased maximal velocity of microtubule assembly. These 2,5-HD-induced in vitro alterations in microtubule assembly were normalized by CBZ exposure. In vivo, adult male rats were exposed to a 1% solution of 2,5-HD in the drinking water for 2.5 weeks. CBZ was administered by gavage (200 mg/kg body weight) at the same time as unilateral surgical ligation of the efferent ducts, 24 hr before evaluation of the testis. Measures of testicular effect (testis weight, histopathologic changes [sloughing and vacuolization], and seminiferous tubule diameters) were all significantly altered with combined exposure. The testicular effects in the combined exposure group were either different (seminiferous tubule diameters), additive (% vacuolization), or greater than additive (% sloughing) compared to the effects of the individual toxicant exposure groups referenced to the controls. Therefore, CBZ coexposure does not antagonize the effects of an initial 2,5-HD exposure, as might be expected if their molecular effects on microtubule assembly were solely responsible for their combined toxicityinstead, 2,5-HD and CBZ act together to exacerbate the testicular injury.... Detailed toxicity tests were performed to determine whether effects of mixtures of copper-cadmium and copper-carbendazim on Caenorhabditis elegans were similar to the effects of the individual compounds. Effects on the course of reproduction, the length of the juvenile period, the length of the reproductive period, and body length were analyzed. Dose-response data were compared to the additive model and tested for four deviation patterns from additivity: No deviation, synergistic/antagonistic deviation, dose ratio-dependent deviation, dose level-dependent deviation. During the exposure, the cadmium-copper effect on reproduction changed from a synergistic, to a dose ratio-dependent deviation from additivity. More cadmium in the mixture decreased the toxicity and more copper increased the toxicity. The effect of copper-carbendazim on reproduction was synergistic at low dose levels and antagonistic at high dose levels and independent of time. Mixture effects on the juvenile and reproductive period were similar to single component effects. It was concluded that the observed time-dependence of toxic interactions was small and that interactions on the timing of reproduction were not found. The additive model underestimated mixture effects on reproduction and body length.The fungicide Carbendazim Methyl-2-benzimidazole carbamate (MBC) is known to produce male reproductive toxicity. The present study has been undertaken to investigate the impact of vitamin E, an antioxidant against the testicular toxicity induced by MBC. HPLC analysis showed that the amount of MBC in testis and serum was 57.40 +/- 3.38 nmol/g and 14.10 +/- 0.84 nmol/mL, respectively, in rats treated with carbendazim + vitamin-E, which were significantly lower than that of rats treated with carbendazim alone (240 +/- 15.60 nmol/g and 318.70 +/- 22.52 nmol/mL, respectively). MBC treatment significantly decreased the testicular weight while co-administration of vitamin-E registered normal testicular weight. Histomorphometric analysis revealed a significant decrease (P < 0.05) in the diameter of the seminiferous tubules and lumen in MBC-treated rats compared to control whereas they remained normal in vitamin E + MBC-treated rats. Leydig cells appeared dispersed and hypertrophic after MBC treatment. Various histopathological changes were observed in testis of rats treated with MBC whereas these changes were absent in vitamin-E + MBC-treated rat testis. In conclusion protection against MBC-induced toxicity was observed with co-administration of vitamin E with MBC.For more Interactions (Complete) data for CARBENDAZIM (18 total), please visit the HSDB record page.
건강 영향Carbendazim is a suspected endocrine disruptor. It is also a developmental toxin. Animals exposed to carbendazim in the womb to have serious deformities such as lack of eyes and hydrocephalus (water on the brain). Carbendazim can disrupt the development of sperm and damage testicular development in adult rats.
생태독성 수치LD50Species: /Coturnix japonica/ (Japanese quail) oral 10,996 mg/kgEC50Species: Eisenia andrei (Earthworm) adult, weight 50-60 mgwatered exposure (artificial soil, pH 5.03, organic matter 1.28%) <1 mg/kg for 48 hrEffect: chemical avoidanceSpecies: Eisenia andrei (Earthworm) adult, well developed clitellumdirect application (artificial soil, pH 6.0) 0.88 mg/kg dry soil for 56 daysEffect: reproductiondecreased progeny counts/numbersSpecies: Eisenia fetida (Earthworm) adult, Europeandirect application (natural soil, pH 6.1, organic matter 6.17%) 127.4 mg/kg for 48 hr (95% confidence interval: 90.1-179.6 mg/kg)For more Ecotoxicity Values (Complete) data for CARBENDAZIM (19 total), please visit the HSDB record page.
환경 거동TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 122.3-2805(2-3), indicate that carbendazim is expected to have high mobility in some soils with decreasing mobility as the amount of clay and organic carbon content increases, pH will have a lesser effect on mobility. Volatilization of carbendazim from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.5X10-12 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Carbendazim is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 7.5X10-10 mm Hg at 25 °C(5). Measured soil biodegradation rates of 45% in 21 days and 45% in 14 days suggest that carbendazim is expected to biodegrade slowly under normal environmental conditions(6). However, biodegradation rates of 100% in 5 days and 97% in 9 days suggest that biodegradation of carbendazim will be enhanced in pretreated soils(6).TERRESTRIAL FATE: Carbendazim is absorbed through the roots and green tissues of plants, with translocation acropetally.AQUATIC FATE: Based on a classification scheme(1), Koc values of 122.3-2805(2-3), indicate that carbendazim is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 1.5X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). Measured hydrolysis half-lives for carbendazim at 22 °C were >350 days at pH 5-7 and 124 days at pH 9(6). According to a classification scheme(7), BCFs of <1.5-3.5 measured in carp(8), suggest bioconcentration in aquatic organisms is low(SRC). A 0% of Theoretical BOD using activated sludge in the Japanese MITI test(8) suggests that biodegradation is not an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), carbendazim, which has a vapor pressure of 7.5X10-10 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase carbendazim may be removed from the air by wet and dry deposition(SRC).
식품 조사 수치In a Total Diet Study conducted in the US (samples collected Oct 1, 1984 to Sept 30, 1991) carbendazim was not detected in domestic samples (number tested) of apple juice (114), banana (72), grape juice (32), plain (2739) and vitamin D (180) milk, orange juice (13), oranges (862) and pears (571)(1). Carbendazim was detected in 20 of 2464 domestic apple samples at a maximum of 1.7 ppm(1). Carbendazim was not detected in imported apple juice (351), apples (735), grape juice (24), orange juice (64), oranges (474) or pears (816). Carbendazim was detected in imported fruit at maximum residues of 0.26, 0.66 and 0.54 ppm in 1 of 1097 bananas, 1 of 474 oranges, and 2 of 816 pears, respectively(1). Carbendazim was detected in 55 of 56 oranges and 97 of 134 tangerines sampled in 2001 from Valencia, Spain at 0.03-0.6 and 0.02-0.13 mg/kg, respectivelyit was not detected in 13 watermelon and 24 persimmons(2). In samples of 27 different vegetables procured from retail markets of Karachi, India during 2000-2003, carbendazim was detected at unreported concentrations in carrot, garlic, onion, potato, spinach, chillies French bean, lady's finger and pumpkin(3). Carbendazim was not detected in ginger, radish, sugar beet, turnip, Brassica leaves, coriander, methi, mint, salad, brinjal, bittergourd, Indian squash, cucumber, luffa, peas, tomato, cabbage or cauliflower(3). Carbendazim was detected at <0.01 ng/kg in >60% of 33 fruit based baby foods sampled from Spain and the United Kingdom(4). Carbendazim was detected in 38 of 145 mushroom samples obtained from wholesale cooperatives in Northern Ireland between 1997 and 1999(5). Carbendazim was detected in Bramley apple flesh, core and peel at <0.43, 2.2 and 5.2 mg/kg, respectivelyapples were treated with Ridomil mbc 60 WP post harvest(6). Carbendazim was detected at a mean level of 1.05 mg/kg in 5 of 150 citrus samples from an agricultural co-operative of the Valencian Community, Spain(7). In a Total Diet Study conducted in Kuwait, of the 140 food items tested carbendazim was detected only in grapes and mandarin oranges at 0.5 and 0.4 mg/kg, respectively(8).Carbendazim was not detected in the following domestic (D) and imported (I) Danish food samples taken in 1978 and 1979: banana(I), plum(D and I), peach (I), nectarines (I), grapefruit (I), carrot (D and I), potato (D and I), chervil (D), cabbage (D and I), onion (I), leek (D), pear (D and I), rhubarb (D), red beets (D), celeriac (D), spinach (D) and tomato (I)(1). Carbendazim was detected in other commodities as follows(1):[Table#6072]
유해 작용Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
노출 경로The substance can be absorbed into the body by inhalation of its aerosol.Inhalation (L793)oral (L793)dermal (L793)
Milk ConcentrationsCarbendazim was not detected (detection limit not reported) in 2739 and 180 plain and vitamin D milk samples, respectivelysamples collected Oct 1, 1984 to Sept 30, 1991 in the US(1).
독성 요약IDENTIFICATION AND USE: Carbendazim is a white powder. it is a systemic leaf and soil fungicide, absorbed through the roots and green tissues. HUMAN EXPOSURE AND TOXICITY: Six human chromosomes were investigated in pairs (1 and 8, 11 and 18, and X and 17). Abnormalities were classified as chromosome loss (including centromeric positive micronuclei), chromosome gain, non-disjunction, or polyploidy. ANIMAL STUDIES: Previous studies indicate that carbendazim may interfere with mitosis and thus may disrupt or inhibit microtubule function resulting in apoptosis. Carbendazim even at low dose exhibited toxicity, affected the liver and also caused specific changes in hematological and biochemical parameters in the rat. Male rats (6 per dose level) were gavaged with 200, 3400 and 5000 mg/kg 5 days/wk for 2 wk. Two out of the 6 rats died at the dose level of 3400 mg/kg per day. At all dose levels, gross and microscopic evidence of adverse effects on the testes and reduction or absence of sperm in the epididymides was seen. The testes were small and discolored, with tubular degeneration and evidence of aspermatogenesis. At the dose level of 3400 mg/kg per day, there were also morphological changes in the duodenum (edema and focal necrosis), bone marrow (reduction in the blood forming elements) and liver (decrease in the large globular shaped vacuoles). Groups of 1 yr old beagles (4 males, 4 females) were admin carbendazim in the diet for 3 months at dietary levels of 0, 100, 500 and 2500 mg/kg. Females at the mid dose level showed a trend toward incr cholesterol levels at 1, 2 and 3 months compared with the pre-test and control values. High dose females also had elevated cholesterol levels. Organ to body weight changes were observed in the case of the thymus of low and mid dose males and the prostate of mid dose males. Groups of pregnant rats were administered carbendazim by gavage on days 6-15 of gestation at dose levels up to 80 mg/kg/day. Groups of pregnant rabbits were similarly administered up to 160 mg/kg/day on days 6-18 of gestation. In the rats, dead and resorbed fetuses accounted for 29% of conceptions in controls, 48% at 20 mg/kg, 64% at 40 mg/kg, and 73% at 80 mg/kg. In rabbits, no dead or resorbed fetuses were seen in controls whereas 15-33% were found in carbendazim-treated rabbits. There were no differences among rats or rabbits in mean weight of live fetuses, and there were no malformations. Carbendazim induced chromosome aberrations in spermatids with a high incidence of aneuploidy. Carbendazim induced micronuclei in mouse bone marrow cells. 2,3-diaminophenazine (DAP) and 2-amino-3-hydroxyphenazine (AHP) were detected in mutagenic carbendazim samples. Carbendazim samples containing DAP or AHP at levels as low as 5 or 10 ppm, respectively, were positive in the Salmonella/Ames test with activation when tested at 5000 ug/plate. Purified carbendazim was not mutagenic. ECOTOXICITY STUDIES: Amazonian fish appeared to be slightly less sensitive for carbendazim than temperate fish with LC50 values ranging between 1648 and 4238 ug/L, and Amazonian invertebrates were found to be significantly more resistant than their temperate counterparts, with LC50 values higher than 16000 ug/L. In plants, carbendazim causes methylation or demethylation of certain genes and changes the expression of these genes.Carbendazim targets beta tubulin in actively dividing cells. It binds to microtubules, interfering with cell functions, such as meiosis and intracellular transportation (A15332).
Average Daily IntakeThe estimated dermal and inhalation exposure to workers applying pesticides to flower crops in greenhouses in Colombia were 20 and 0.03 mg/day, respectively10% of the dermal exposure was expected to be adsorbed through the skin resulting in 2 mg/day absorbed(1).
생태독성 발췌/BIRDS and MAMMALS/ ... This report is that of an investigation on the response of the testis of the Japanese quail to experimental administration of /carbendazim/ in sexually mature and active birds. A single dose (400 mg/kg body weight) of carbendazim was administered orally to 20 quails that were sacrificed thereafter at 5 hr, 3, 8 and 13 days post-exposure, at five birds spatio-temporally. Five birds acted as control. Testis weights and seminiferous tubular diameter as well as epithelial height decreased significantly from 8 day post-exposure. Epithelial histology was remarkably disrupted, and cessation of spermatogenesis occurred at 13 day post-administration of the chemical. Degenerative changes were uniform in each testis, and not patchy or multi-focal, as previously reported in the rat. The observed histological changes in the testis, due to carbendazim, were capable of causing prolonged infertility in exposed birds./BIRDS and MAMMALS/ The study investigated the effect of various doses of carbendazim on the morphology of the magnum of the Japanese quail. No morphological changes were observed in the magnum in birds treated with carbendazim at doses of 25 mg/kg and 100 mg/kg bodyweight. A carbendazim dose of 400 mg/kg bodyweight was the lowest dose which caused morphological changes in the magnum. Histologically, carbendazim caused pyknosis and glandular atrophy in the magnum mucosa. Carbendazim also caused significant decreases in the height of the mucosal folds, epithelial height, glandular width and glandular luminal diameter at 400 mg/kg and 800 mg/kg (p<0.05). At ultrastructural level, dose-dependent deciliation was observed. Pyknotic nuclei, dilated cisternae of rough endoplasmic reticulum, swollen mitochondria, numerous vacuoles and lysosomes in the luminal and glandular epithelia were identified. The observed degenerative changes could be due to cytoskeletal disruption caused by carbendazim toxicity. Degeneration of the luminal and glandular cells in the magnum pose a potential threat to the egg production and reproduction of exposed birds./AQUATIC SPECIES/ ... In this study, the two main conceptual models for mixture evaluation based on the effect of individual compounds, concentration addition (CA) and independent action (IA) and deviations to synergism/antagonism, "dose ratio" and "dose level" dependency were used. The single and combined effects of cadmium, carbendazim and low dissolved oxygen levels were assayed for life-cycle parameters (survival and feeding) of the water flea Daphnia magna Straus. The results of single exposures revealed an increase of acute and chronic toxicity as concentrations of cadmium and carbendazim increases. At low dissolved oxygen levels both survival and feeding parameters were significantly affected (p</=0.05). In the acute mixture exposure of cadmium and carbendazim a "dose ratio" dependency was observed with a higher toxicity when cadmium was dominant whereas at high concentrations ofcarbendazim a lower effect on survival was observed. At chronic exposures an antagonistic deviation from IA model was observed for this mixture. The IA model showed to be adequate for toxicity prediction on acute exposure combinations with low DO levels where a synergistic behavior was observed. However, at sublethal exposures IA and CA models failed by underestimation. .../AQUATIC SPECIES/ A model ecosystem experiment was conducted to investigate the ability of an in situ Daphnia magna feeding bioassay to assess impairment of ecosystem function. Animals were deployed in model ecosystems dosed with different concentrations of the fungicide carbendazim, and effects on the postexposure feeding rate of D. magna were compared with effects on zooplankton species richness (ecosystem structure) and development of phytoplankton biomass (ecosystem function). In the medium-dosed systems (21 ug/L), a structural change was observed within the zooplankton community, but no indirect effects on phytoplankton development were detected. It appears that at this treatment level, functional redundancy was sufficient to prevent functional impairment despite species loss. The feeding assay did not show any response at this concentration. In the high-dosed systems (221 ug/L), structural changes in the zooplankton community were accompanied by increased development of phytoplankton biomass. The feeding bioassay also showed a significant response at this concentration. At the high treatment level, species loss resulted in functional impairment, indicating that at this level, functional redundancy could not compensate for loss of individuals. The D. magna feeding bioassay matched well with the functional response (i.e., the indirect effects on phytoplankton) in the dosed systems but not with the more subtle effects on zooplankton community structure. ...For more Ecotoxicity Excerpts (Complete) data for CARBENDAZIM (20 total), please visit the HSDB record page.
CERCLA 보고 수량Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV.D.3.b).
수질 위해 등급(WGK)3
TSCA 등재 상태TSCA listed
RTECS 번호DD6500000
운송 번호(UN)UN 3077 9/PG 3
독성LD50 oral in rabbit: 8160mg/kg
관세 코드29339900
위험 문구(R)46-60-61-50/53-39/23/24/25-23/24/25-11-52/53
위험 표시T,N,F,Xn
안전 문구(S)53-45-60-61-36/37-16
기존화학 물질KE-02676
위험 등급Aquatic Acute 1Aquatic Chronic 1Muta. 1BRepr. 1BSkin Sens. 1
저장 분류6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
유해 물질 데이터10605-21-7(Hazardous Substances Data)