Acetamide, N-(trimethylsilyl)-

trimethylsilyl · N-TRIMETHYLSILYLACETAMIDE · TMSA · CMH3 · DK063 · CMD1Y · LVNC9 · C15orf13

https://huagongshe.com/ko/chemical/25989

식별자 및 물리적 특성

CAS No.	13435-12-6
분자식	C5H13NOSi
평균 분자량	131.25 g/mol
단동위원소 질량	131.07664057 g/mol
SMILES	CC(=O)N[Si](C)(C)C
InChIKey	LWFWUJCJKPUZLV-UHFFFAOYSA-N
PubChem CID	25989
EC No.	236-565-7
DTXSID	DTXSID8065454

화학 및 물리적 성질

극성 표면적	29.1
수소 결합 공여자 수	1
수소 결합 수용자 수	1
회전 가능 결합 수	1
무거운 원자 수	8
형식 전하	0
복잡도	95
녹는점	46-49 °C(lit.)
끓는 점	84 °C18 mm Hg(lit.)
밀도	0.859±0.06 g/cm3(Predicted)
인화점	135 °F
저장 조건	Inert atmosphere,Room Temperature
용해도	클로로포름, DMSO, 메탄올 에 용해됨
pKa(산도 계수)	18.23±0.46(Predicted)
물리적 상태	결정질 덩어리
색상	흰색에서 노란색으로
용해도	물과 반응
BRN	741928
안정성	수분에 민감한
InChI	1S/C5H13NOSi/c1-5(7)6-8(2,3)4/h1-4H3,(H,6,7)
InChIKey	LWFWUJCJKPUZLV-UHFFFAOYSA-N
SMILES	CC(=O)N[Si](C)(C)C
EPA	Acetamide, N-(trimethylsilyl)- (13435-12-6)

화학적 성질

WHITE TO YELLOWISH CRYSTALLINE MASS

안전 및 규제

GHS 분류	This chemical does not meet GHS hazard criteria for 84.4% (38 of 45) of all reports.WarningH315 (11.1%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (11.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)Aggregated GHS information provided per 45 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 38 of 45 reports by companies.There are 4 notifications provided by 7 of 45 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
규제 정보	Chemical: Acetamide, N-(trimethylsilyl)-Acetamide, N-(trimethylsilyl)-: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and Categories	Skin Irrit. 2 (11.1%)Eye Irrit. 2 (11.1%)
수질 위해 등급(WGK)	3
TSCA 등재 상태	TSCA listed
RTECS 번호	AD0250000
운송 번호(UN)	1325
관세 코드	29319090
위험 문구(R)	36/37/38-11
위험 표시	Xi-F,Xi,F
안전 문구(S)	37/39-26
포장분류	III
위험 등급	4.1Eye Irrit. 2Skin Irrit. 2

용도

N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).

일반 설명

The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied.