트라이스(2-클로로아이소프로필)인산

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation.

Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

For more Preventive Measures (Complete) data for Tri-(2-chloroisopropyl) phosphate (6 total), please visit the HSDB record page.

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Wear self contained breathing apparatus for fire fighting if necessary.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 290(SRC), determined from a log Kow of 2.59(2) and a regression-derived equation(3), indicates that tri-(2-chloroisopropyl)phosphate is expected to have moderate mobility in soil(SRC). Volatilization of tri-(2-chloroisopropyl)phosphate from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.0X10-8 atm-cu m/mole(SRC), using a fragment constant estimation method(4). Tri-(2-chloroisopropyl)phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 9.2X10-3 mm Hg at 25 °C(SRC), determined from a fragment constant method(3). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(2) indicating that biodegradation is not an important environmental fate process in soil(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 290(SRC), determined from a log Kow of 2.59(2) and a regression-derived equation(3), indicates that tri-(2-chloroisopropyl)phosphate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(4) based upon an estimated Henry's Law constant of 6.0X10-8 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). According to a classification scheme(6), a BCF range of 0.8 to 2.8(2) suggests bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(2) indicating that biodegradation is not an important environmental fate process in water(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tri-(2-chloroisopropyl)phosphate, which has an estimated vapor pressure of 9.2X10-3 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist solely in the vapor phase in the ambient atmosphere. Vapor-phase tri-(2-chloroisopropyl)phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 0.2 days(SRC), calculated from its rate constant of 4.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Tri-(2-chloroisopropyl)phosphate does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of March 1, 2013: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=13674-84-5]

Tri-(2-chloroisopropyl)phosphate influent and effluent concentrations were 2.79 and 2.26 ug/L, respectively, at the Kalby Sewage Treatment Plant in Lund, Sweden; sampling was conducted on October 21, 2002. Samples were collected upstream and downstream of the plant located on the Hoje River(1).

The Koc of tri-(2-chloroisopropyl)phosphate is estimated as 290(SRC), using a log Kow of 2.59(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that tri-(2-chloroisopropyl)phosphate is expected to have moderate mobility in soil.

INDOOR: Tri-(2-chloroisopropyl)phosphate was detected at concentrations of 63, 46, 57, and 130 ng/cu m in a theater, furniture store 1 and 2, and an office, respectively, collected from locations in Zurich, Switzerland. The compound was not detected in three electronic stores nor 2 other offices, detection limit = 0.12 ng/cu m(1).

/GENOTOXICITY/ In an initial unscheduled DNA synthesis (UDS) assay, human WI-38 cells blocked in G1 phase were grown in a medium containing Fyrol PCF in DMSO at concentrations of 0.1, 0.5, 1 or 5 uL/mL. In one series, S9 from Arochlor-pretreated rat livers provided the activation system. N-methyl nitroguanidine was used as the positive control in the activation system, while benzo(a)pyrene was used as the positive control in the nonactivated system. A second assay was conducted because Fyrol PCF concentrations above 0.1 uL/mL were too toxic. The second assay employed Fyrol in DMSO at concentrations of 5, 10, 50 and 100 nL/mL...Fyrol PCF was perhaps weakly active at 0.01 uL/mL in activated and nonactivated systems without an associated dose response at higher concentrations.

AEROBIC: Tri-(2-chloroisopropyl)phosphate, present at 100 mg/L, reached 0% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). A low removal efficiency of 19% was noted for the Kalby Sewage Treatment plant in Lund, Sweden which releases treated effluent into the Hoje River(2).

Tris(chloropropyl) Phosphate

TR-602: Toxicology and Carcinogenesis Studies of an Isomeric Mixture of Tris(chloropropyl) Phosphate Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice (2023 )

11/01/22

Some Evidence

Some Evidence

Some Evidence

Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. 2-Propanol, 1-chloro-, phosphate (3:1) is included on this list. Effective date: 12/16/88; Sunset date: 11/9/93.

Used as a flame retardant primarily for polyurethane foams; Minor uses include textile back-coating formulations and special coatings; [Reference #1] Also used in adhesives and binding agents, insulating materials, extinguishing agents, fillers, construction materials, intermediates, and paints, lacquers, and varnishes; [HSDB]

Painting (Pigments, Binders, and Biocides) [Category: Paint]

Flame retardant, mainly in polyurethane foams

Adhesives, binding agents; insulating materials; flame retardants and extinguishing agents; fillers; construction materials; paints, lacquers and varnishes; intermediates.

2023: 40,000,000 - <55,000,000 lb

2-Propanol, 1-chloro-, phosphate (3:1) is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: 2-Propanol, 1-chloro-, phosphate (3:1). Aggregated National Production Volume: 10 to < 50 million lbs.

Non-confidential 2012 Chemical Data Reporting (CDR) information on the production and use of chemicals manufactured or imported into the United States. Chemical: 2-Propanol, 1-chloro-, 2,2',2''-phosphate. National Production Volume: 54,673,933 lb/yr.

Fyrol PCF

Amgard TMCP

Antiblaze 80

Levagard PP

Tolgard TMCP

Miscellaneous Manufacturing

2-Propanol, 1-chloro-, 2,2',2''-phosphate: ACTIVE

... preferred additive for rigid urethane foams where favorable price and good storage stability in the isocyanate or the polyol-catalyst mixture are required. It is used in isocyanate foam to reduce friability and brittleness and is also used in flexible urethane foams in combination with melamine

Tris(monochloropropyl) phosphates theoretically comprise four different symmetrical isomers...Although tris(1-chloro-2-propyl) phosphate (CAS No. 13674-84-5) is the most abundant isomer in commercial products, companies have tended to refer to their product by the name tris(2-chloropropyl) phosphate (TCPP), though that name refers to CAS No. 6145-73-9. This has led to a considerable degree of uncertainty in the literature and toxicity databases as to the identity of the substance that has undergone toxicity testing.

TMCPP was commercialized in the mid-1960s and production increased by about 4 % per year the next 30 years. In 2002, Finland had the highest use (among the Nordic countries) with 1 000 tonnes/year and Sweden the lowest with 100 tonnes/year. The major use of TMCPP is as a flame retardant, mainly in polyurethane foams. The highest TMCPP level was reported from a polyurethane foam filler (180 g/kg). Lower concentrations were reported from polyurethane- containing carpet backing (13 g/kg), mattresses (1.5 g/kg) and wallpaper of glass fibre (1 g/kg) (98). TMCPP has been found to be emitted from upholstery at rates of up to 77 ug/m2/hour.