| GHS 분류 | DangerH226: Flammable liquid and vapor [Warning Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.2% (13 of 6636) of reports.H226 (99.8%): Flammable liquid and vapor [Warning Flammable liquids] |
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| 규제 정보 | Chemical: 1-Butanol1-Butanol is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Butanol are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 09-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15322Butanol: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.1-Butanol: HSNO Approval: HSR001096 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
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| 기타 안전 정보 | IMAP assessments - 1-Butanol: Environment tier I assessment |
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| 운송 라벨(DOT) | Flammable Liquid |
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| 화재 위험 | Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.Flammable. Above 29 °C explosive vapour/air mixtures may be formed. |
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| 화재 가능성 | Flammable liquid. Moderately explosive when exposed to flame. |
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| 건강 유해성 | Anesthesia, nausea, headache, dizziness, irritation of respiratory passages. Mildly irritating to the skin and eyes. (USCG, 1999)· May cause toxic effects if inhaled or absorbed through skin. |
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| 유해성 요약 | A skin, eye, and respiratory tract irritantInhalation of high concentrations can cause CNS depression[ICSC] |
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| 운송 번호 및 가이드(DOT) | 1120 129 |
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| FDA 요건 | n-Butyl alcohol may be used in inks for marking food supplements in tablet form, gum, and confectionery. Restriction: No residue. |
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| 반응성 그룹 | Alcohols and Polyols |
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| UN 분류 | UN Hazard Class: 3UN Pack Group: III |
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| Special Reports | Brusewitz S, Wennberg AArbetarskyddsstyrelsen (1984). Criteria document for setting exposure limits for butanol and butyl acetate. |
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| 소화 | Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]:Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
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| 응급 조치 | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention if skin irritation occurs.Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.Rinse mouth. Give nothing to drink. Do NOT induce vomiting. Refer immediately for medical attention. |
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| 누출 비상 조치 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
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| 응급 처치 | Excerpt from NIOSH Pocket Guide for n-Butyl alcohol:General First Aid:(General first aid procedures) |
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| 안전 보관 | Fireproof. Separated from strong oxidants and aluminium. Store only in original container. See Chemical Dangers. |
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| Firefighting Hazards | Flashback along vapor trail may occur. |
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| 노출 관리 및 개인 보호 | · Wear positive pressure self-contained breathing apparatus (SCBA).4784.0 [ppm]100.0 [ppm] |
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| 소화 절차 | Special hazards arising from the substance or mixture: carbon oxides...Advice for firefighters: wear self contained breathing appartus for fire fighting if necessary.Use water spray to cool unopened containersSuitable extinguishing media: use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. |
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| 정리 방법 | ACCIDENTAL RELEASE MEASURES. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.Waste water treatment: Activated carbon: absorbability: 0.107 g/g C, 53% reduction, influent: 1,000 mg/L, effl: 466 mg/LReverse osmosis: 41.3% rejection from a 0.01 M solnStabilization pond design: toxicity correction factor: 2.0 at 4,000 mg/L influentAnaerobic lagoon: 22 lb Chemical Oxygen Demand (COD)/day/1,000 cu ft: influent: 170 mg/L, effluent: 75 mg/L48 lb COD/day/1,000 cu ft: influent: 170 mg/L, effluent: 80 mg/L |
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| 비화재 누출 대응 | Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: |
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| 처리 방법 | Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers U031 and F003, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.Contaminated packaging: Dispose of as unused product.Incineration: Incinerate by atomizing into a suitable combustion chamber.For more Disposal Methods (Complete) data for N-BUTYL ALCOHOL (6 total), please visit the HSDB record page. |
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| 누출 처리 | Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Wash away remainder with plenty of water. |
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| 체내 부담 | n-Butyl alcohol was identified, not quantified, in human blood(1) and mother's milk(2). n-Butyl alcohol was detected in human breath samples at concentrations of 1-10 ppb(3). The concentration of n-butanol in expired air from 8 individuals ranged from 1.3-35.0 ug/hr(4). n-Butyl alcohol was detected at concentrations of 0.02 and 0.08 ng/L in 2 samples of the expired air of 54 individuals(5). n-Butyl alcohol was detected at a mean concentration of 1.6 ug/cu m in the exhaled breath of Belgian workers exposed to a solvent mixture(6). |
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| 상호 작용 | The effects of combined exposure to m-xylene and n-butyl alcohol on rotarod performance and motor activity in rats and respiratory rate in mice were investigated in the condition of an acute inhalation experiment. Rotarod performance and motor activity were tested in rats exposed to various concentrations of m-xylene, n-butyl alcohol and their mixture consisting of 50 Vol-% m-xylene and 50 Vol-% n-butyl alcohol immediately after termination of a 4-hour exposure period. The respiratory rate in mice was recorded in short 6 min duration exposures to individual solvents and their 50:50 Vol-% mixture. Both solvents and mixtures caused concentration-dependent disturbances of rotarod performance in rats. The medial effective concentration (EC50) for the effect amounted 6530 ppm, 1980 ppm and 3080 ppm for n-butyl alcohol, m-xylene and their mixture, respectively. Both solvents and their mixture changed the spontaneous motor activity in the rat. Because of a two-phase effect, the concentration-dependence of the observed changes could not be defined. The evaluation of the combined effect in motor activity test was carried out by comparing experimental values with expected ones assuming the summation of individual solvent effects. The tested solvents resulted in a concentration-dependent decrease in respiratory rate in mice. The concentration which decreased the respiratory rate to 50% (RD50) was 3010 ppm, 1360 ppm and 3140 ppm for n-butyl alcohol, m-xylene and their mixture, respectively...The activity of partially purified human erythrocyte acid phosphatase (eapase) was enhanced 4-fold by n-butanol. The extent of human prostatic acid phosphatase (papase) activation by n-propanol was lower than that of eapase. Eapase & papase activation by aliphatic alcohols, including n-butanol was noncompetitive.Potentiates bactericidal effects of alcohol, ethyl & alcohol, propyl.Pretreatment with n-butanol (10 mmol/kg i.p.) 30 minutes before alloxan (100 mg/kg) protects mice from the permanent hyperglycemic effects (measured at 72 hours) of the diabetogenic agent. This dose of n-butanol caused an elevation of serum glucose at 30 minutes, the time of alloxan administration. Since glucose administration can protect animals from alloxan, the possibility that alcohol-induced hyperglycemia protected mice from alloxan was investigated. Mannoheptulose, an antagonist of glucose action at the pancreatic beta-cell, when given 24 minutes after n-butanol and 6 minutes before alloxan, eliminated the alcohol-induced protection. Fasted mice did not exhibit n-butanol-induced hyperglycemia at 30 minutes and alloxan given at that time produced diabetes. No protection was observed in fed animals when n-butanol was given 5 minutes before alloxan. The high serum levels of butanol and normal serum glucose which were observed at 5 minutes after alcohol administration indicated that the lack of protection was not due to a lack of circulating alcohol but resulted from an absence of hyperglycemia. The results indicate that pretreatment with n-butanol protects mice from alloxan-induced diabetes by the indirect mechanism of producing hyperglycemia at the time of alloxan administration. |
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| 표적 장기 | NervousEyes, skin, respiratory system, central nervous system |
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| 생태독성 수치 | LC50Species: Pimephales promelas (fathead minnow) /4-8 wk juvenile, length 1.1-3.1 cm, Conditions: freshwater, static, 18-22 °C, dissolved oxygen >4.0 mg/L/Concentration: 1940 mg/L for 24, 48, 72, 96 hr /formulation/EC50Species: Daphnia magna (water flea)Conditions: /freshwater, static/Concentration: 2337 mg/L for 24 hrEffect: lost ability to swimConcentration: 1983 mg/L for 48 hrSpecies: Enteromorpha intestinalis (Green Algae)Conditions: saltwater, static, 15 °CConcentration: 135 mM for 24 hrEffect: physiology, decreased neutral red uptake /95-99.8% purity/For more Ecotoxicity Values (Complete) data for N-BUTYL ALCOHOL (15 total), please visit the HSDB record page. |
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| 환경 거동 | TERRESTRIAL FATE: Based on a classification scheme(1), a measured Koc value of 3.2(2) indicates that n-butyl alcohol is expected to have very high mobility in soil(SRC). Volatilization of n-butyl alcohol from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 8.81X10-6 atm-cu m/mole(3). n-Butyl alcohol is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 7 mm Hg at 25 °C(4). n-Butyl alcohol biodegrades rapidly in screening tests using a sewage or activated sludge inoculum and is considered readily biodegradable(5). The biodegradation half-life of n-butyl alcohol in a sub-surface soil from Blacksburg, VA was approximately 7 days(6).AQUATIC FATE: Based on a classification scheme(1), a Koc value of 3.2(2) indicates that n-butyl alcohol is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected to be an important fate process(3) based upon a Henry's Law constant of 8.81X10-6 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 3.7 and 29, days respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low. Hydrolysis is not expected to be an important environmental fate process(SRC) since this compound lacks functional groups that hydrolyze under environmental conditions(3). n-Butyl alcohol biodegrades rapidly in screening tests using a sewage or activated sludge inoculum and is considered readily biodegradable(8). In a river die-away test, n-butyl alcohol achieved 33% of its theoretical BOD in 5 days(9), suggesting biodegradation may be an important fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), n-butyl alcohol, which has a vapor pressure of 7 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase n-butyl alcohol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC). The half-life for the reaction in air with hydroxyl radicals is estimated to be 45 hours(SRC), calculated from its rate constant of 8.5X10-12 cu cm/molecule-sec at 25 °C(3). n-Butyl alcohol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). |
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| 식품 조사 수치 | n-Butyl alcohol was identified, not quantified, in the volatile emissions of roasted filberts(1), raw beef(2), Frankfurter sausages(3) and roasted almonds(4). n-Butyl alcohol was detected in soybeans at concentrations of 199.9 to 1,586.2 ug/kg(5). The volatile emission rate of n-butanol from Bisbee apples harvested from the state of Washington was 8.6 to 35.1 picoliters/kg-hr(6). n-Butyl alcohol was detected in the volatile components of fish sauce(7). n-Butyl alcohol occurs as a product of fermentation of carbohydrates in alcoholic beverages and has been detected in the volatiles of various foods such as cheese, heat-treated milk, muskmelon, and cooked rice(8). n-Butyl alcohol has been qualitatively detected in beer, whiskey, grape and apple brandies and hop volatiles(9). |
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| 유해 작용 | Neurotoxin - Acute solvent syndrome |
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| 노출 경로 | The substance can be absorbed into the body by inhalation of its vapour and by ingestion.inhalation, skin absorption, ingestion, skin and/or eye contact |
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| Milk Concentrations | n-Butanol was identified, not quantified, in 3 of 12 samples of mother's milk(1). |
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| 독성 요약 | Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgIDENTIFICATION: n-Butyl Alcohol (BA) is an aliphatic alcohol with a rancid sweet odor, that is liquid at room temperature. n-Butyl Alcohol has numerous applications in the plastics and textile sector. It is ofen used as an industrial intermediate, converted into derivatives including butyl acetate and other butyl esters, which serve as solvents or monomer components in the production of artificial leather, textiles, safety glass, rubber cement, shellac, raincoats, photographic films, or perfumes. n-Butyl Alcohol can also be used directly as a solvent for paints, lacquers and varnishes, natural and synthetic resins, gums, vegetable oils, dyes and alkaloids. It is historically used as a solvent in nail care cosmetic products, and is also being used at low concentrations in eye makeup, personal hygiene, and shaving cosmetic products. n-Butyl Alcohol has been generally recognized as safe for use as a flavoring substance in food and appears on the 1982 Food and Drug Administration (FDA) list of inactive ingredients for approved prescription drug products. HUMAN EXPOSURE AND TOXICITY: Human exposure to n-butyl alcohol may occur in the workplace during manufacture and industrial/commercial use, and during consumer use of products containing n-butyl alcohol. Workers complained of ocular irritation, disagreeable odor, slight headache and vertigo, slight irritation of nose and throat, and dermatitis of the fingers and hands when the air concentration of n-Butyl Alcohol was greater than 50 ppm. Short term inhalation of n-butanol also produces a variety of CNS effects, including giddiness, ataxia, confusion, delirium, and possible coma. In high concentration in the air it can cause transient mild edema of conjunctiva of the eye, and a slightly reduced erythrocyte count. Inhalation toxicity studies in humans demonstrate sensory irritation of the upper respiratory tract, but only at levels above 3000 mg/cu m. n-Butyl Alcohol ingestion may result in vomiting, abdominal pain, headache, drowsiness and unconsciousness. Nail enamel containing 3% n-Butyl Alcohol resulted in no reactions. ANIMAL STUDIES: Animal studies demonstrate intoxication, restlessness, ataxia, prostration, and narcosis with exposure to n-butyl alcohol. High concentrations of n-Butyl Alcohol vapors can be fatal. Ocular irritation was observed for n-Butyl alcohol at 0.005 mL of a 40% solution. The behavioral no-effect dose for n-Butyl Alcohol injected subcutaneously (s.c.) was 120 mg/kg. Fetotoxicity has been demonstrated, but only at maternally toxic levels (1000 mg/kg). No significant behavioral or neurochemical effects were seen in offspring following either maternal or paternal exposure to 3000 or 6000 ppm. n-Butyl Alcohol was not mutagenic in the Ames tests and did not have any chromosome-damaging effects in a mouse micronucleus test. ECOTOXICITY STUDIES: BA exhibits low toxicity to fish, amphibians and aquatic invertebrates, plants, algae, bacteria and protozoans. However, some algal species are sensitive to BA. Acute toxicity to aquatic life may occur at concentrations greater than 500 mg/L. |
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| 생태독성 발췌 | /OTHER TOXICITY INFORMATION/ BA exhibits low toxicity to fish, amphibians and aquatic invertebrates, plants, algae, bacteria and protozoans. However, some algal species are sensitive to BA. Acute toxicity to aquatic life may occur at concentrations greater than 500 mg/L./PLANTS/ N-propanol, n-butanol, and isobutanol at 1x10-4 molar promoted cell elongation and increased total growth of wheat roots grown in white lighthigher concentration inhibited meristematic activity. |
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| Plant Concentrations | Plants containing n-butyl alcohol(1).[Table#76] |
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| RCRA 요건 | U031As stipulated in 40 CFR 261.33, when n-butyl alcohol, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).F003When n-butyl alcohol is a spent non-halogenated solvent, it is classified as a hazardous waste from a nonspecific source (F003), as stated in 40 CFR 261.31, and must be managed according to State and/or Federal hazardous waste regulations. |
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| FIFRA 요건 | Residues of n-butanol are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: solvent, co solvent.Residues of n-butanol are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals. Use: solvent for blended emulsifiers. |
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| 대기 기준 | This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. n-Butyl alcohol is produced, as an intermediate or a final product, by process units covered under this subpart. |
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| CERCLA 보고 수량 | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
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| 주 식수 지침 | (MN) MINNESOTA 700 ug/L(FL) FLORIDA 700 ug/L |
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| 신호 어 | Danger |
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| 유해·위험 문구 | 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H225 |
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