기본 정보
- CAS
14919-77-8- 표준 SMILES
Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O- InChIKey
ULFCBIUXQQYDEI-UHFFFAOYSA-N- 분자식
- C10H16ClN3O5
- 평균 분자량
- 293.7 g/mol
- 단동위원소 질량
- 293.0778483
개요
Benserazide hydrochloride is a hydrochloride that is the monohydrochloride salt of benserazide. An aromatic-L-amino-acid decarboxylase inhibitor (DOPA decarboxylase inhibitor) that does not enter the central nervous system, it is used as an adjunct to levodopa in the treatment of parkinsonism. By preventing the conversion of levodopa to dopamine in the periphery, it causes an increase in the amount of levodopa reaching the central nervous system and so reduces the required dose. Benserazide hydrochloride has no antiparkinson actions when given alone. It has a role as an antiparkinson drug, a dopaminergic agent and an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor. It contains a benserazide(1+).
이름 및 식별자
- 우선 이름
- Benserazide Hydrochloride
- IUPAC
- 2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide;hydrochloride
- 영어명
- Benserazide hydrochloride
- 분자식
- C10H16ClN3O5
- 분자량
- 293.7
이름 및 동의어
BENSERAZIDE HYDROCHLORIDE14919-77-8Benserazide HCl2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide hydrochlorideRo 4-4602/0012'-(2,3,4-Trihydroxybenzyl)-DL-serinohydrazide monohydrochlorideDTXSID0045412DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazine hydrochlorideB66E5RK36QCHEBI:31262DTXCID8025412RefChem:1077794
이름 더 보기
RO 4-4602BENPARIZDE31796-68-6NCGC00093698-03SPECTRUM1500137Benserazide hydrochloBenserazid hydrochloride
(2RS)-2-Amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanoylhydrazide monohydrochloride238-991-9Benzerazide hydrochlorideBenserazide HCIDL-SERINE 2MFCD00078571Benserazide hydrochloride [JAN]DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride
데이터베이스 식별자
- CAS
14919-77-8- PubChem CID
- 26964
물성
구조 계산 물성
- 극성 표면적
- 148 Ų
- 수소 결합 공여자 수
- 8
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 19
- 형식 전하
- 0
- 복잡도
- 278
실험 및 물리화학적 성질
Solubility35.4 [ug/mL] (The mean of the results at pH 7.4)
물리화학적 성질
- 녹는점
- 146 °C · 146°C
- 저장 조건
- 2 · 2-8°C
- 용해도
- 2 O: · H2O: 10 mg/mL
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
- 수소이온지수(pH)
- pH(10g/L, 25℃) : 4.0～5.0
- 생물학적 소스
- synthetic
- 수용성
- 물, 디메틸설폭사이드 및 메탄올에 용해됩니다. 에탄올과 아세톤에 용해되지 않습니다.
- Merck
- 14 · 14,1050
- InChI
- InChI=1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H
- InChIKey
- ULFCBIUXQQYDEI-UHFFFAOYSA-N
- SMILES
- C(NNCC1=CC=C(O)C(O)=C1O)(=O)C(CO)N.[H]Cl
화학적 성질
White Crystalline Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H315 (43%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 93 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesSkin Irrit. 2 (43%)
안전 데이터
- wgk
- 2
- rtecs
- VT9632300
- HS 번호
- 29280000
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26-36
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
개요Benserazide is an inhibitor of aromatic L-amino acid decarboxylase (AADC), an enzyme that has dopamine decarboxylase activity. It is also unable to cross the blood-brain barrier. As a result, benserazide blocks the conversion of L-DOPA to dopamine by AADC in the peripheral circulatory system. Benserazide is often combined with L-DOPA in patients with Parkinson’s disease.
용도Inhibitor of L-aromatic amino acid decarboxylaseBenserazide hydrochloride is used as an antiparkinsonian. It is a peripheral decarboxylase inhibitor. It is used as an inhibitor for aromatic L-aminoacid decarboxylase. Further, it serves as an inhibitor of tyrosine hydroxylase (TH) and Tryptophan hydroxylase (TPH) inhibitor.
일반 설명Benserazide is a peripheral decarboxylase inhibitor.
공급사100 곳
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
河北展药生物科技有限公司15369953316 +8615369953316 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
北京华威锐科化工有限公司0757-86329057 18934348241 · [email protected]
관련 반응
0건
현재 필터 조건에 해당하는 반응 기록이 없습니다.
화합물 노트
불러오는 중…