Tempo

HCID 2724126CAS 2564-83-2
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기본 정보

표준 SMILES
CC1(C)CCCC(C)(C)N1[O]
InChIKey
QYTDEUPAUMOIOP-UHFFFAOYSA-N
분자식
C9H18NO
평균 분자량
156.25 g/mol
단동위원소 질량
156.1388392

개요

TEMPO is a member of the class of aminoxyls that is piperidine that carries an oxidanediyl group at position 1 and methyl groups at positions 2, 2, 6, and 6, respectively. It has a role as a ferroptosis inhibitor, a catalyst and a radical scavenger. It is a member of piperidines and a member of aminoxyls.

이름 및 식별자

우선 이름
Tempo
IUPAC
(2,2,6,6-Tetramethylpiperidin-1-yl)oxidanyl
영어명
TEMPO
분자식
C9H18NO*
분자량
156.25

이름 및 동의어

TEMPOTananeTanan2,2,6,6-Tetramethyl-1-piperidinyloxy2,2,6,6-Tetramethylpiperidine-1-oxylTetramethylpiperidinooxyVQN7359ICQTetramethylpiperidine nitroxideDTXSID20733001-Piperidinyloxy, 2,2,6,6-tetramethyl-CHEBI:328492,2,6,6-tetramethyl-4-piperidine-N-oxide
이름 더 보기
TEPOTMEPO2,2,6,6-Tetramethylpiperidin-1-oxyl2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL(2,2,6,6-Tetramethylpiperidin-1-yl)oxyl2,2,6,6-Tetramethylpiperidoxyl
RefChem:187806DTXCID7037345219-888-82564-83-22,2,6,6-Tetramethylpiperidinooxy2,2,6,6-Tetramethylpiperidine 1-oxyl(2,2,6,6-tetramethylpiperidin-1-yl)oxidanylMFCD00009599

데이터베이스 식별자

CAS
2564-83-2
PubChem CID
2724126
DTXSID
DTXSID2073300
ChEMBL
CHEMBL606971
ChEBI
CHEBI:32849
UNII
VQN7359ICQ
EC Number
219-888-8
Nikkaji
J1.968.655H、J100.807B、J2.763.954B

물성

구조 계산 물성

XLogP
1.4
극성 표면적
4.2 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
1
회전 가능 결합 수
0
무거운 원자 수
11

실험 및 물리화학적 성질

Chemical ClassesNitrogen Compounds -> Amine Oxides
Vapor Pressure0.000006 [mmHg]
Physical DescriptionDark red solid; [Merck Index] Red crystalline solid; mp = 32-37 deg C; [Alfa Aesar MSDS]

물리화학적 성질

녹는점
36 · 36-38 °C(lit.)
끓는 점
193 °C · 193°C
밀도
1 g/cm3 · 1 g/cm3
증기압
0.4 hPa · 0.4 hPa (20 °C)
굴절률
1.435 · 1.4350 (estimate)
인화점
154 °F · 154 °F

화학적 성질

orange crystals or powder

안전 및 규제

GHS 분류

GHS Classification · 5건

This chemical does not meet GHS hazard criteria for 1.2% (5 of 403) of reports.

Danger

H314 (93.1%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P264, P264+P265, P273, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 403 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 3건

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Status: Active Update: 15-11-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/24636

2,2,6,6-Tetramethylpiperidine-1-oxyl: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryA severe skin and eye irritant; Causes somnolence in dermal lethal-dose studies of rabbits; [RTECS] Causes burns; [Alfa Aesar MSDS]
Hazard Classes and CategoriesSkin Corr. 1B (93.1%)

독성 정보

Adverse EffectsDermatotoxin - Skin burns.
Toxicity DataLCLo (rat) = 4,500 mg/m3/2hr

안전 데이터

wgk
3
tsca
TSCA listed
rtecs
TN8991900
ridadr
UN 3263 8/PG 2
HS 번호
29333999
risk_code
34-36/37/38

화학 및 산업

약리 정보

MeSH Pharmacological ClassificationNaturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues.

용도 및 제조

UsesUsed in organic chemistry (radical trap, catalyst, and polymerization mediator); [Merck Index] Used as a spin label in MRI; [REPROTOX]
General Manufacturing Information1-Piperidinyloxy, 2,2,6,6-tetramethyl-: ACTIVE
응용 분야 · 4건

용도주요 유기 합성 중간체.

개요2,2,6,6-Tetramethylpiperidine is a product that is used for the most diverse purposes because of its strong basicity, for example, as a light stabilizer for polyolefins, as a cocatalyst in olefin polymerizations (Ziegler catalysts), as a building block for the synthesis of pharmaceuticals and crop protection products, as a cocatalyst in the synthesis of dichloroacetyl chloride. The 4-unsubstituted 2.2.6,6-tetramethylpiperidine is generally prepared from the corresponding 4-oxo compound. It is known that triacetonamine can be converted by hydrazine to the hydrazone, which is then cleaved in the presence of alkali into 2,26,6-tetramethylpiperidine and nitrogen.

용도TEMPO(2,2,6,6-Tetramethylpiperidinooxy) is a stable radical prepared through the oxidation of 2,2,6,6-tetramethylpiperidine. TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthe sis and as a structural probe in electron spin resonance spectroscopy. TEMPO can also be used as a mediator in free radical polymerization.

일반 설명For a synthetic protocol using NMP initiators, contributed by Prof. Karen Wooley, please visit our technology spotlight.

상·하류 제품 정보

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]

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