기본 정보
- CAS
75277-39-3- 표준 SMILES
O=S(=O)([O-])CCN1CCN(CCO)CC1.[Na+]- InChIKey
RDZTWEVXRGYCFV-UHFFFAOYSA-M- 분자식
- C8H17N2NaO4S
- 평균 분자량
- 260.29 g/mol
- 단동위원소 질량
- 260.08067248
이름 및 식별자
- 우선 이름
- Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate
- IUPAC
- sodium 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonate
- 현지명
- 4-(2-하이드록시에틸)피페라진-1-에탄설포닉 산, 나트륨 염 (1:1)
- 영어명
- HEPES sodium salt
- 분자식
- C8H19N2NaO4S
- 분자량
- 261.3
이름 및 동의어
이름 더 보기
데이터베이스 식별자
- CAS
75277-39-3- PubChem CID
- 2724248
- DTXSID
DTXSID4044458- ChEMBL
CHEMBL3187284- ChEBI
CHEBI:46758- UNII
- Z9FTO91O8A
- EC Number
- 278-169-7
- Nikkaji
- J307.551F
물성
구조 계산 물성
- 극성 표면적
- 92.3 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 16
- 형식 전하
- 0
- 복잡도
- 272
실험 및 물리화학적 성질
Physical Description
Dry Powder
White powder; [Sigma-Aldrich MSDS]
물리화학적 성질
- 녹는점
- 234 °C · 234 °C
- 밀도
- 1.504 · 1.504[at 20℃]
- 증기압
- 0 Pa · 0Pa at 25℃
- 저장 조건
- room temp
- 용해도
- 2 O: · H2O: 1 M at 20 °C, 투명, 무색
- 물리적 상태
- 건조 분말
- 색상
- 하얀색
- 수소이온지수(pH)
- 10 · 10.0-12.0 (1M in H2O)
- 산도 계수 (pKa)
- 7.5 · 7.5(at 25℃)
- 생물학적 소스
- synthetic
- 수용성
- 물에 용해됩니다.
- 안정성
- 안정적인. 흡습성 - 습기로부터 보호합니다. 강한 산화제와 호환되지 않습니다.
- InChI
- 1S/C8H18N2O4S.Na.H2O/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14;;/h11H,1-8H2,(H,12,13,14);;1H2/q;+1;/p-1
- InChIKey
- ZNJHFNUEQDVFCJ-UHFFFAOYSA-M
- SMILES
- O.[Na+].OCCN1CCN(CC1)CCS([O-])(=O)=O
- EPA
- 1 · 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt (75277-39-3)
- Absorption
- 0.2 at · ≤0.2 at 260 in H2O at 1M≤0.2 at 280 in H2O at 1M
화학적 성질
white powder
안전 및 규제
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 98.8% (160 of 162) of all reports.
Not Classified;Reported as not meeting GHS hazard criteria by 160 of 162 companies (only 1.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website.
Aggregated GHS information provided per 162 reports by companies from 3 notifications to the ECHA C&L Inventory.;Reported as not meeting GHS hazard criteria per 160 of 162 reports by companies.;There is 1 notification provided by 2 of 162 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
유해성 정보
Regulatory Information
Chemical: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
Status: Active Update: 08-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/21261
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
규제 정보
Regulatory Information
Chemical: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
Status: Active Update: 08-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/21261
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, monosodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
안전 데이터
- wgk
- 3
- tsca
- TSCA listed
- HS 번호
- 29335995
- safety_code
- 22-24/25
- F 고인화성물질
- 3-10
- 스토리지 클래스
- 13 - Non Combustible Solids
화학 및 산업
용도 및 제조
General Manufacturing Information
Pharmaceutical and Medicine Manufacturing
1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-, sodium salt (1:1): ACTIVE
응용 분야
용도HEPES sodium salt solution is suitable for cell culture studies. It may be used in the preparation of buffer solution of HEPES. It may be used as buffer during the phosphorylation assays in permeabilized fibroblasts. It may be used to compose a complex dialysis buffer, used in the determination of free thyroxin in serum by radioimmunoassay.
일반 설명HEPES is a general-purpose zwitterionic buffer which does not bind magnesium, calcium, manganese(II) or copper(II) ions. HEPES has been classified as Good′s buffer by Dr. Norman Good and his colleagues in 1966. It is zwitterionic at biological pH and is most effective in the pH range of 6.8 to 8.2.
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