CAS 1070-89-9 Sodium bis(trimethylsilyl)amide (HCID 2724254)

이름 및 식별자

우선 이름: Sodium bis(trimethylsilyl)amide
IUPAC: sodium bis(trimethylsilyl)azanide
영어명: Sodium bis(trimethylsilyl)amide
분자식: C6H18NNaSi2
분자량: 183.37

이름 및 동의어

Sodium bis(trimethylsilyl)amideN-SodiohexamethyldisilazaneEINECS 213-983-8Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, sodium saltDTXSID5061451EC 213-983-8Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, sodium salt (1:1)NSodiohexamethyldisilazaneRefChem:887345DTXCID9033052Silanamine, 1,1,1trimethylN(trimethylsilyl), sodium salt213-983-8

이름 더 보기

SODIUM HEXAMETHYLDISILAZIDENHMDSsodium bis(trimethylsilyl)amide solutionHMDS NaSodium Bis(trimethylsilyl)amide, 1M THFSodiobis(trimethylsilyl)amineodium bis(trimethylsilyl)amide

1070-89-9NaHMDSHexamethyldisilazane sodium saltsodium;bis(trimethylsilyl)azanideC6H18NNaSi2MFCD00009835sodium hexamethyldisilazanes14980

데이터베이스 식별자

CAS: 1070-89-9
PubChem CID: 2724254
DTXSID: DTXSID5061451
UNII: X9ZJB79YER
EC Number: 213-983-8
Nikkaji: J364.613K

물성

구조 계산 물성

극성 표면적: 1 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 1
회전 가능 결합 수: 2
무거운 원자 수: 10
형식 전하: 0
복잡도: 80

실험 및 물리화학적 성질

Physical DescriptionOff-white odorless crystals; [Alfa Aesar MSDS]

물리화학적 성질

녹는점: 171 · 171-175 °C (lit.)
끓는 점: 67 °C · 67°C
밀도: 0.904 g/mL · 0.904 g/mL at 25 °C
인화점: 43 °F · 43 °F
저장 조건: 2 · 2-8°C
용해도: 헥산, 톨루엔, 에테르, 테라히드로푸란, 벤젠 및 톨루엔에 용해됩니다.
물리적 상태: 액체
Specific Gravity: 0.9 · 0.9
색상: 투명한 주황색에서 갈색까지
수용성: 물과 반응
BRN: 3629917 · 3629917
InChI: 1S/C6H18NSi2.Na/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
InChIKey: WRIKHQLVHPKCJU-UHFFFAOYSA-N
SMILES: C[Si](C)(C)N([Na])[Si](C)(C)C
EPA: 1 · Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, sodium salt (1070-89-9)

화학적 성질

Slightly yellow to light beige crystalline powder

안전 및 규제

GHS 분류

GHS Classification · 5건

Danger

H302 (63.4%): Harmful if swallowed [Warning Acute toxicity, oral]；H312 (63.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]；H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H318 (64.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H332 (63.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]；H412 (63.8%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 235 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 2건

Status: Active Update: 17-11-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/11731

Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, sodium salt: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryReacts violently with water evolving extremely flammable gases; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Alfa Aesar MSDS]

Hazard Classes and CategoriesAcute Tox. 4 (63.4%)；Acute Tox. 4 (63.8%)；Skin Corr. 1B (100%)；Eye Dam. 1 (64.3%)；Acute Tox. 4 (63.4%)；Aquatic Chronic 3 (63.8%)

안전 및 보호

Protective Action Criteria (PAC) · 3건

30 [mg/m3]

330 [mg/m3]

2000 [mg/m3]

독성 정보

Adverse EffectsDermatotoxin - Skin burns.；Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

규제 정보

Regulatory Information · 2건

Status: Active Update: 17-11-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/11731

Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, sodium salt: Does not have an individual approval but may be used under an appropriate group standard

안전 데이터

wgk: 3
tsca: TSCA listed
ridadr: UN 3263 8/PG 2
HS 번호: 29319090
risk_code: 14-34-19-11-67-65-63-48/20-14/15-40-37
hazard_code: C,F
safety_code: 26-45-62-36/37/39-33-16-43-8
포장분류: III
위험 등급: 4.3
F 고인화성물질: 10-21
Hazard Classifications: Skin Corr. 1B
스토리지 클래스: 8A - Combustible corrosive hazardous materials

화학 및 산업

용도 및 제조

General Manufacturing InformationSilanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, sodium salt (1:1): ACTIVE

응용 분야 · 2건

용도Sodium bis(trimethylsilyl)amide is a synthetically useful reagent in that it combines both high basicity and nucleophilicity, each of which may be exploited for useful organic transformations such as selective formation of enolates, preparation of Wittig reagents, formation of acyl anion equivalents, and the generation of carbenoid species. As a nucleophile, it has been used as a nitrogen source for the preparation of primary amines.It is useful as a sterically hindered base and as a nucleophile.

일반 설명Sodium bis(trimethylsilyl)amide solution (NaHMDS) is widely used as a strong base in organic synthesis for deprotonation reactions and base-catalyzed reactions. It is also involved in the generation of enolates, Wittig reagents and carbenes.