(+)-Berbamine

개요Berbamine is an alkaloid, separated from Berberidaceae, Menispermaceae, or Ranunculaceae plants. Most of Berberidaceae plants have medicinal value, including their root, root bark, and stem. The plants of Berberis L. and Mahonia Nutt. contain many alkaloids, the most important of which are berberine and a small amount of palmatine, jatrorrhizine, berbamine, oxyacanthine, and so on. These compounds have many biological activities and have been used to replace goldthread and golden cypress. Also they are well succedaneums of berberine in Chinese and Western medicine. Traditional Chinese medicine Oregon grape root has different therapeutic effects for dysentery, enteritis, children pneumonia, and chronic bronchitis. The major treatment diseases of Chinese mahonia are bacillary dysentery, acute gastritis, infectious hepatitis, pneumonia, tuberculosis, bronchitis, sore throat, and so on.

역사Berbamine is an alkaloid mainly from Berberis julianae, Berberis wilsonae, Berberis poiretii, and huanglumu, which belong to Berberidaceae berberis and Mahonia. Nowadays, it mainly comes from chemical synthesis. Berbamine hydrochloride is contained in the 13th volume of the book, Hua xue yao ping di biao sheng guo biao. As early as 1940, the United States scholars had obtained berbamine from Mahonia . Chinese scholars began the research of berbamine extraction and pharmacological activities since the 1980s in the last century .Although the berbamine study in our country later than the west, the traditional Chinese medicine Berberi’s medicinal records can be traced back to the Tang Dynasty. The book Tang Ben Cao recorded that Oregon grape root could be a therapy for aphtha, kill insects, and remove hot gas in the body. In the Ming Dynasty the book Ben Cao Gang Mu recorded that Oregon grape root could treat metrorrhagia. Now, berbamine is widely used for leukopenia.

용도antihypertensive, skeletal muscle relaxant