아세톤 티오쎄미카르바존

Synthesis of Acetone Thiosemicarbazone (ACTSC):Thiosemicarbazide (0.01 mol, 0.182 g) was dissolved in methanol (30 mL) under reflux at 50 °C. To this refluxing solution, a solution of acetone (0.1 mol, 0.87 mL) in methanol (30 mL) was added, followed by a few drops of concentrated HCl. The reaction mixture was stirred and refluxed continuously for 4 hours at 60 °C. The volume of the mixture was then reduced, and the solution was cooled in an ice-water bath. The precipitated crystals of acetone thiosemicarbazone were collected, washed with methanol, and dried in a desiccator over silica gel.