Manganese(2+)

HCID 27854CAS 16397-91-4

기본 정보

표준 SMILES: [Mn+2]
InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
분자식: Mn+2
평균 분자량: 54.938 g/mol
단동위원소 질량: 54.93694794

개요

Manganese(2+) is a divalent metal cation in which the metal is manganese. It has a role as a cofactor. It is a manganese cation, a monoatomic dication and a divalent metal cation.

이름 및 식별자

우선 이름: Manganese(2+)
IUPAC: manganese(2+)
영어명: Manganeseion
분자량: 0

이름 및 동의어

Manganese(2+)Manganese(II)Manganous ionManganese (Mn2+)Manganese ion(2+)Mn2+MANGANESE(II) IONManganese, ion (Mn2+)16397-91-4Manganese dicationManganese cation (2+)Manganous cation

이름 더 보기

Mn(II)Manganese cation (Mn2+)Mn++Mn(2+)H6EP7W5457Manganese cationManganese(2+)ionsmanganese ion

데이터베이스 식별자

CAS: 16397-91-4、7439-96-5
PubChem CID: 27854
DTXSID: DTXSID00167687
ChEBI: CHEBI:29035
UNII: H6EP7W5457
Nikkaji: J1.387.540E、J1.601.472I

물성

구조 계산 물성

극성 표면적: 0 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 0
회전 가능 결합 수: 0
무거운 원자 수: 1
형식 전하: 2
복잡도: 0

실험 및 물리화학적 성질

Melting Point1244 °C

Physical DescriptionSolid

화학 및 산업

약리 정보

Protein BindingManganese is reported to bind to a number of carriers, such as transmanganin, beta-globulin, and transferrin. It is also reported to bind to serum albumin but to a minimal extent.

PharmacodynamicsProviding manganese (Mn) during TPN helps prevent the development of deficiency symptoms such as nausea and vomiting, weight loss, dermatitis, and changes in hair growth and colour.

Mechanism of Action · 1건

Mn2+ is an essential cofactor and activator for many enzymes that regulate biological functions and processes, such as oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases. These enzymes include polysaccharide polymerase, liver arginase, cholinesterase, pyruvate carboxylase, and Mn superoxide dismutase (MnSOD). These enzymes regulate immune function, metabolism, growth potential, hemostasis, mitochondrial homeostasis and antioxidant function, and neuronal function.

Metabolism/MetabolitesMn2+ is oxidized to Mn3+ by liver and plasma ceruloplasmin.

Absorption, Distribution and Excretion · 3건

When orally administered, manganese (Mn) is reported to be readily absorbed through the intestinal tract: about 3–5% of dietary Mn is absorbed as Mn2+ and Mn4+. Under conditions of minimal intake, 20 mcg Mn/day is retained following intravenous administration. Assays for manganese in whole blood result in concentrations ranging from six to 12 mcg/Mn/L.

Excretion of manganese occurs mainly through the bile, but in the event of an obstruction, ancillary excretion routes include pancreatic juice or return into the lumen of the duodenum, jejunum, or ileum. Urinary excretion of manganese is negligible.

Mn can cross the blood-brain barrier. Manganese is widely distributed but concentrates in mitochondria-rich tissues such as the brain, kidney, pancreas, and liver.

Tissue LocationsBasal Ganglia