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기본 정보
- CAS
16595-80-5- 표준 SMILES
Cl.c1ccc([C@H]2CN3CCSC3=N2)cc1- InChIKey
LAZPBGZRMVRFKY-HNCPQSOCSA-N- 분자식
- C11H13ClN2S
- 평균 분자량
- 240.759 g/mol
- 단동위원소 질량
- 240.0487971
이름 및 식별자
- 우선 이름
- Levamisole hydrochloride
- IUPAC
- (6S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole--hydrogen chloride (1/1)
- 영어명
- Levamisole hydrochloride
- 분자식
- C11H13ClN2S
- 분자량
- 240.75
이름 및 동의어
LEVAMISOLE HCLTETRAMISOLE HCLLEVAMISOL HYDROCHLORIDEcitarinlERGAMISOLLevamisole HCIdecarisLevadinDekarisr-12,564
데이터베이스 식별자
- CAS
16595-80-5- PubChem CID
- 27944
- DTXSID
DTXSID7047518- ChEMBL
CHEMBL1770- ChEBI
CHEBI:6433- UNII
- DL9055K809
- EC Number
- 240-654-6
물성
물리화학적 성질
- 녹는점
- 266 · 266-267 °C(lit.)
- 굴절률
- -126 ° · -126 ° (C=1, H2O)
- 인화점
- 9 ℃ · 9℃
- 저장 조건
- 2 · 2-8°C
- 용해도
- 물에 잘 녹고, 에탄올(96%)에 녹고, 염화메틸렌에는 약간 녹습니다.
- 물리적 상태
- 결정성 분말
- 색상
- 흰색에서 거의 흰색
- 생물학적 소스
- synthetic (organic)
- 수용성
- 210 g/L · 210g/L(20℃)
- Merck
- 14 · 14,5459
- BRN
- 4358988 · 4358988
- BCS Class
- 3 · 3/1
- 안정성
- 흡습성
- 주요 응용
- 법의학 및 독성학의약품(소분자)
- InChI
- InChI=1/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/s3
- InChIKey
- LAZPBGZRMVRFKY-HNCPQSOCSA-N
- SMILES
- [C@H]1(N=C2SCCN2C1)C1=CC=CC=C1.Cl |&1:0,r|
- LogP
- 1.845 · 1.845 (est)
- EPA
- Levamisole hydrochloride (16595-80-5)
화학적 성질
White to light yellow crystalline powder, odorless, bitter taste. Melting point 227-229℃. Soluble in water, methanol, ethanol and glycerol, slightly soluble in chloroform and aether; insoluble in acetone. Stable under acidic conditions, but easy to decompose and fail under alkaline conditions.
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- rtecs
- NJ5960000
- ridadr
- UN 2811 6.1/PG 3
- HS 번호
- 29349990
- risk_code
- 25-20/21/22-39/23/24/25-23/24/25-11
- hazard_code
- T,Xn,F
- safety_code
- 36/37/39-45-28A-36-36/37-16
- 포장분류
- III
- 위험 등급
- 6.1(b)
- 기존화학 물질
- KE-33497
- F 고인화성물질
- 10
- Hazard Classifications
- Acute Tox. 3 Oral
- 스토리지 클래스
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
화학 및 산업
응용 분야
용도Levamisole hydrochloride is an anthelmintic. The activity of levamisole is about twice as high as that of abscisicidal, and the toxicity and side effects are lower. Levamisole can cause muscle paralysis of roundworms and then excrete them in the feces. It is mainly used as an anti-worm and anti-hookworm.
용도Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.
제조 방법
Levamisole hydrochloride was prepared from racemic tetraimidazole by splitting, alkali analysis and acidification into salt.Dibenzoyl-D-tartaric acid is boiled in water for 40min, hydrolyzed and neutralized with sodium hydroxide solution to pH 7.5, and then added to racemic tetraimidazole. The levamisole is precipitated by generating salt with bisbenzoyl-tartaric acid. After separation, add sodium hydroxide solution to PH=9 and decompose levamisole. Then dissolved in dilute hydrochloric acid solution, after decolorization by activated carbon, the filtrate was concentrated nearly dry, and crystallized by adding acetone and cooling to 0℃. Filtered and dried to obtain levamisole hydrochloride.
상·하류 제품 정보
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