CAS 218156-96-8 Srpin340 (HCID 2797577)

개요

Serine-Arginine-Rich Protein Kinase Inhibitor

이름 및 식별자

우선 이름: Srpin340
IUPAC: N-[2-piperidin-1-yl-5-(trifluoromethyl)phenyl]pyridine-4-carboxamide
현지명: SRPK억제제
영어명: SRPK inhibitor
분자식: C18H18F3N3O
분자량: 349.35

이름 및 동의어

SRPIN340218156-96-8SRPIN-3409QS4MR9N9DRefChem:932150N-(2-(Piperidin-1-yl)-5-(trifluoromethyl)phenyl)isonicotinamideSRPIN 340SRPK inhibitorN-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamideMFCD00116244N-[2-(Piperidin-1-yl)-5-(trifluoromethyl)phenyl]pyridine-4-carboxamideN-[2-piperidin-1-yl-5-(trifluoromethyl)phenyl]pyridine-4-carboxamide

이름 더 보기

SRPK억제제CS-910SRPIN340, >=98%SRPIN340 >=98% (HPLC)SRPIN340, 10 mM in DMSOSRPK Inhibitor(SRPIN340)SRPIN340 (SRPK inhibitor)

4-Pyridinecarboxamide, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-CHEMBL4064277N-[2-(1-piperidyl)-5-(trifluoromethyl)phenyl]isonicotinamideN-[2-(1-piperidyl)-5-(trifluoromethyl)phenyl]pyridine-4-carboxamideN-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamideSRPIN340?orb1225648orb1306986

데이터베이스 식별자

CAS: 218156-96-8
PubChem CID: 2797577
ChEMBL: CHEMBL4064277
UNII: 9QS4MR9N9D
EC Number: 808-979-3
Nikkaji: J2.385.677H

물성

구조 계산 물성

XLogP: 3.5
극성 표면적: 45.2 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 6
회전 가능 결합 수: 3
무거운 원자 수: 25
형식 전하: 0
복잡도: 445

물리화학적 성질

끓는 점: 395.9 · 395.9±42.0 °C(Predicted)
밀도: 1.306 · 1.306±0.06 g/cm3(Predicted)
저장 조건: 2 · 2-8°C
용해도: 20 mg/mL, · DMSO: 용해성20mg/mL, 투명
물리적 상태: 가루
산도 계수 (pKa): 11.09 · 11.09±0.70(Predicted)
색상: 흰색에서 베이지색
안정성: 1 · 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 1개월 동안 보관할 수 있습니다.
InChI: 1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25)
InChIKey: DWFGGOFPIISJIT-UHFFFAOYSA-N
SMILES: O=C(C1=CC=NC=C1)NC2=C(N3CCCCC3)C=CC(C(F)(F)F)=C2

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 4 (100%)

안전 데이터

wgk: 3
risk_code: 22
hazard_code: Xn
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

응용 분야 · 2건

개요Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1. SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.

용도SRPIN340 is a SRPK1 kinase inhibitor, which shows potential novel targeted therapeutic strategy in prostate cancer.