Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
DL-Carnitine
Cardiogen · Carrier · Cardiogen peptide · Carnum · Miocor · C00487 · Novaine · Excitine
식별자 및 물리적 특성
| CAS No. | 406-76-8 |
|---|---|
| 분자식 | C7H15NO3 |
| 평균 분자량 | 161.2 g/mol |
| 단동위원소 질량 | 161.10519334 g/mol |
| SMILES | C[N+](C)(C)CC(O)CC(=O)[O-] |
| InChIKey | PHIQHXFUZVPYII-UHFFFAOYSA-N |
| PubChem CID | 288 |
| ChEMBL | CHEMBL172513 |
| ChEBI | CHEBI:17126 |
| EC No. | 206-976-6 |
| DTXSID | DTXSID3022744 |
화학 및 물리적 성질
| XLogP | -0.2 |
|---|---|
| 극성 표면적 | 60.4 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 3 |
| 무거운 원자 수 | 11 |
| 형식 전하 | 0 |
| 복잡도 | 134 |
| 화장품 | Cosmetic ingredients (Carnitine) -> CIR (Cosmetic Ingredient Review)CleansingFoam boosting |
| Dietary Ingredients | Carnitine |
| Collision Cross Section | 131.39 Ų [M]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| 녹는점 | 197-198 °C (decomp) |
| 저장 조건 | Store at -20°C |
| 용해도 | DMSO에 용해됨 |
| InChI | InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3 |
| InChIKey | PHIQHXFUZVPYII-UHFFFAOYSA-N |
| SMILES | C(C(O)CC([O-])=O)[N+](C)(C)C |
안전 및 규제
| 규제 정보 | Carnitine: Does not have an individual approval but may be used under an appropriate group standard |
|---|---|
| 노출 경로 | Intravenous, Oral. Absolute bioavailability is 15% (tablets or solution). Time to maximum plasma concentration was found to be 3.3 hours. |
| 독성 요약 | The CIR Expert Panel concluded the following ingredients are safe in the present practices of use and concentration described in the safety assessment when formulated to be non-irritating...Carnitine...Safe for use in cosmetics, with qualificationsLevocarnitine can be synthesised within the body from the amino acids lysine or methionine. Vitamin C (ascorbic acid) is essential to the synthesis of carnitine. Levocarnitine is a carrier molecule in the transport of long chain fatty acids across the inner mitochondrial membrane. It also exports acyl groups from subcellular organelles and from cells to urine before they accumulate to toxic concentrations. Only the L isomer of carnitine (sometimes called vitamin BT) affects lipid metabolism. Levocarnitine is handled by several proteins in different pathways including carnitine transporters, carnitine translocases, carnitine acetyltransferases and carnitine palmitoyltransferases. |
| Signs and Symptoms | Adverse effects include hypertension, fever, tachycardia and seizures. |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| Toxicity Data | LD<sub>50</sub> > 8g/kg (mouse, oral). |
| 신호 어 | Warning |
| 유해·위험 문구 | 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302 |
용도
용도
DL-Carnitine is a Chloride salt free form of D,L-Carnitine Chloride (C184100). Carnitine is a vitamin, essential cofactor of fatty acid metabolism. It is required for the transport of fatty acids through the inner mitochondrial membrane. Synthesized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.