Lisuride

HCID 28864CAS 140387-89-9

기본 정보

표준 SMILES: CCN(CC)C(=O)N[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1
InChIKey: SORAZNWVQFKAFD-IBIFCFAISA-N
분자식: C20H26N4O
평균 분자량: 338.4 g/mol

개요

Lisuride is a monocarboxylic acid amide. It has a role as a serotonergic agonist, an antiparkinson drug, a dopamine agonist and an antidyskinesia agent. It derives from a hydride of an ergoline.

이름 및 식별자

우선 이름: Lisuride
IUPAC: 3-[(6aR,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea
영어명: S-(-)-LISURIDE
분자식: C20H26N4O
분자량: 338.45

이름 및 동의어

LISURIDELysuride18016-80-3LisuridaLisuridumDoperginN'-((8alpha)-9,10-Didehydro-6-methylergolin-8-yl)-N,N-diethylureaE0QN3D755ODTXSID3023217CHEBI:51164Methylergol CarbamideLysurid

이름 더 보기

LisuridCABERQOLINEMesorgydinePrestwick_525S-(-)-LISURIDELisuride (S)(-)(+)-(5R,8S)-Lisuride

Urea, N'-((8alpha)-9,10-didehydro-6-methylergolin-8-yl)-N,N-diethyl-3,3-diethyl-1-[(4S,7R)-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaen-4-yl]ureaMesylate, Lisuride3,3-diethyl-1-((4S,7R)-6-methyl-6,11-diazatetracyclo(7.6.1.0^(2,7).0^(12,16))hexadeca-1(16),2,9,12,14-pentaen-4-yl)ureaRevanil 200Carbamide, MethylergolHydrochloride, LisurideRefChem:799371

데이터베이스 식별자

CAS: 140387-89-9、18016-80-3
PubChem CID: 28864
DTXSID: DTXSID3023217
ChEMBL: CHEMBL157138
ChEBI: CHEBI:51164
UNII: E0QN3D755O
EC Number: 241-925-1
Nikkaji: J10.957F

물성

구조 계산 물성

XLogP: 2.7
극성 표면적: 51.4 Å²
수소 결합 공여자 수: 2
수소 결합 수용자 수: 2
회전 가능 결합 수: 3
무거운 원자 수: 25
형식 전하: 0
복잡도: 544

실험 및 물리화학적 성질

DrugsPharmaceuticals -> Listed in ZINC15

LogP2.2

Solubility1.40e-01 g/L

Human DrugsBreast Feeding; Lactation; Antiparkinson Agents; Dopamine Agonists; Serotonin Receptor Agonists

Physical DescriptionSolid

물리화학적 성질

녹는점: 186 ° · 186°
끓는 점: 603.4 · 603.4±55.0 °C(Predicted)
밀도: 1.23 · 1.23±0.1 g/cm3(Predicted)
산도 계수 (pKa): 13.06 · 13.06±0.20(Predicted)
물리적 상태: Solid
색상: Off-white to light yellow

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

P260, P262, P264, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P316, P320, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 2 (100%)

독성 정보

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

안전 데이터

신호 어: Danger
유해·위험 문구: 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H300

화학 및 산업

약리 정보

ATC Code · 4건

G - Genito urinary system and sex hormones

N - Nervous system

QG - Genito urinary system and sex hormones

QN - Nervous system

Protein Bindingabout 15%

PharmacodynamicsThere is evidence that lisuride lowers prolactin levels and, in low doses, prevents migraine attacks.

Mechanism of Action · 1건

Lisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. It is also thought to bind to the dopamine receptor and to act as a dopamine agonist. Evidence has also emerged that Lisuride also binds to the Histamine H1 receptor.

MeSH Pharmacological Classification · 3건

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.

Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS.

Drugs that bind to and activate dopamine receptors.

Cellular LocationsMembrane

공급사6 곳

中梦研（湖北）科技有限公司0717-6300888 18062399888 · [email protected]

Shaanxi Dideu New Materials Co. Ltd18192503167 · [email protected]

上海知邦生物医药有限公司021-54285032 18116461626 · [email protected]

湖南嘉航医药科技有限公司85567275 15200744171 · [email protected]

湖北凯隆生物科技有限公司19526384105 · [email protected]

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