터트-뷰틸클로로다이메틸실란

삼차-뷰틸다이메틸실일클로라이드 · 터트-뷰틸클로로다이메틸실란 · 터트-부틸클로로디메틸실란 · 터트-뷰틸클로로다이메틸실란(tert-BUTYLCHLORODIMETHYLSILANE) · 삼차-뷰틸다이메틸실일 클로라이드 · tert-부틸디메틸실릴클로라이드 · TBSCL · TBDMSCL

https://huagongshe.com/ko/chemical/28928

식별자 및 물리적 특성

CAS No.	18162-48-6
분자식	C6H15ClSi
평균 분자량	150.72 g/mol
단동위원소 질량	150.06315469 g/mol
SMILES	CC(C)(C)[Si](C)(C)Cl
InChIKey	BCNZYOJHNLTNEZ-UHFFFAOYSA-N
PubChem CID	28928
ChEBI	CHEBI:85071
EC No.	242-042-4
DTXSID	DTXSID4038843
현지명	터트-뷰틸클로로다이메틸실란

화학 및 물리적 성질

극성 표면적	0
수소 결합 공여자 수	0
수소 결합 수용자 수	0
회전 가능 결합 수	1
무거운 원자 수	8
형식 전하	0
복잡도	81
물질 분류	Toxic Gases & Vapors -> Chlorosilanes
SpringerMaterials Properties	Schoenflies notation
Physical Description	White hygroscopic solid[Merck Index] White crystals with a pungent odor[Alfa Aesar MSDS]
녹는점	86-89 °C (lit.)
끓는 점	125 °C (lit.)
밀도	0.87 g/mL at 20 °C(lit.)
증기압	60-710Pa at 25℃
굴절률	n20/D 1.46
인화점	73 °F
저장 조건	Store below +30°C.
용해도	very sol nearly all common organic solvents such as THF, methylene chloride, and DMF.
물리적 상태	흰색 고체
색상	하얀색
비중	1.225
용해도	클로로포름과 에틸 아세테이트에 용해됩니다. 물에 불용성.
BRN	505999
InChI	1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3
InChIKey	BCNZYOJHNLTNEZ-UHFFFAOYSA-N
SMILES	CC(C)(C)[Si](C)(C)Cl
LogP(분배 계수)	2.5 at 20℃
NIST	Silane, chloro(1,1-dimethylethyl)dimethyl-(18162-48-6)
EPA	Silane, chloro(1,1-dimethylethyl)dimethyl- (18162-48-6)

화학적 성질

tert-Butyldimethylsilyl chloride is a colorless or white solid that is soluble in many organic solvents but reacts with water and alcohols.It is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids.

안전 및 규제

GHS 분류	This chemical does not meet GHS hazard criteria for 23.7% (56 of 236) of reports.DangerH228 (57.6%): Flammable solid [Danger Flammable solids]P210, P240, P241, P260, P261, P264, P264+P265, P271, P273, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P363, P370+P378, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 236 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
규제 정보	Chemical: Silane, chloro(1,1-dimethylethyl)dimethyl-Status: Active Update: 30-11-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/28118Silane, t-butylchlorodimethyl-: Does not have an individual approval but may be used under an appropriate group standard
유해성 요약	Causes decreased immune response in intraperitoneal lethal-dose studies of mice (LDLo = 1,000 mg/kg)[RTECS] Corrosive[Merck Index] Reacts with water producing hydrochloric acidCauses burnsInhalation may cause corrosive injuries to upper respiratory tract[Alfa Aesar MSDS] See Chlorotrimethylsilane.
Hazard Classes and Categories	Flam. Sol. 1 (57.6%)
유해 작용	Dermatotoxin - Skin burns.
수질 위해 등급(WGK)	2
TSCA 등재 상태	TSCA listed
RTECS 번호	VV2000000
운송 번호(UN)	UN 2925 4.1/PG 2
독성	mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE,Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975Vol. 27MAY1975,
관세 코드	29310095
위험 문구(R)	22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25-37-36/37/38

제조 및 합성 방법

제조 방법

tert-butyldimethylsilyl chloride (TBSCI) was synthesized by the reaction of tert-butyllithium with dichlorodimethylsilane.The pentane solution of dichlorodimethylsilane was cooled to 0°C, and the pentane solution of tert-butyllithium was added dropwise with stirring under nitrogen. The temperature was maintained at 0 °C, stirred for 1.5 h and then heated to 25 °C, and the reaction was continued for 48 h. Distillation, collect 125 ℃ (97.5kPa) fractions, stand to solidify, and obtain tert-butyldimethylsilyl chloride. Yield 70%.