Iodofenphos

Insecticides

Active substance -> EU Pesticides database: Not approved

Pesticides -> Organophosphate Insecticides

log Kow = 5.51

4.61

COLORLESS CRYSTALS

CRYSTALLINE POWDER

Pale yellow oil, solidifies to crystals

AT 20 °C: <2 MG/L WATER; 450 G/L ACETONE, TOLUENE; 810 G/L DICHLOROMETHANE; 30 G/L METHANOL, OCTAN-1-OL

AT 20 °C: BENZENE 61%; ISOPROPANOL 23%, HEXANE 3.3%

Soluble in acetone, xylene. Slightly soluble in alcohol, soluble in water

0.00000082 [mmHg]

8.25X10-7 mm Hg at 20 °C

Danger

H311 (92.9%): Toxic in contact with skin [Danger Acute toxicity, dermal]

P262, P264, P270, P273, P280, P302+P352, P316, P321, P361+P364, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Not irritating to the eyes of rabbits; No clinical signs or skin irritation observed in rats following 19 days of skin applications at 200 mg/kg; No symptoms observed in rats inhaling 246 mg/m3 for six hours; No evidence of neuropathy in hens fed 2000 mg/kg twice at three week interval; [HSDB] Effects in 91 day feeding studies with rats and dogs include inhibition of cholinesterase activity but no gross changes to organs; No evidence of teratogenicity, mutagenicity, or delayed neurotoxicity based on animal studies; [INCHEM PDS: Iodofenphos - 1980] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

A portion of even the most flammable materials is likely to be lost by vaporization. ... The smoke from an open fire used to destroy pesticides will contain some of the poison. Burning should be attempted only in an isolated place. Inhalation of smoke must be avoided. /Pesticides/

49 216 74; Organophosphorus pesticide, liquid, not otherwise specified (compounds and preparations) (insecticides, other than agricultural, NEC)

49 216 75; Organophosphorus pesticide, liquid, not otherwise specified (compounds and preparations) (agricultural insecticides, NEC, liquid)

49 105 44; Organophosphorus pesticide, liquid, not otherwise specified (compounds and preparations) (insecticides, other than agricultural, NEC)

49 105 45; Organophosphorus pesticide, liquid, not otherwise specified (compounds and preparations) (agricultural insecticides, NEC, liquid)

49 216 76; Organophosphorus pesticide, solid, not otherwise specified (compounds and preparations) (insecticides, other than agricultural, NEC)

49 216 77; Organophosphorus pesticide, solid, not otherwise specified (compounds and preparations) (agricultural insecticides, NEC, other than liquid)

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./

The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.

The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

UN 3018; Organophosphorus pesticides, liquid, toxic, not otherwise specified

UN 3017; Organophosphorus pesticides, liquid, toxic, flammable, not otherwise specified, flashpoint between 23 °C and 61 °C

UN 2783; Organophosphorus pesticides, solid, toxic, not otherwise specified

UN 2784; Organophosphorus pesticides, liquid, flammable, toxic, not otherwise specified, flashpoint less than 23 °C

For more Shipping Name/ Number DOT/UN/NA/IMO (Complete) data for IODOFENPHOS (6 total), please visit the HSDB record page.

Biological Exposure Indices (BEI) [ACGIH] - Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, liquid, NOS/

If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, solid, NOS/

... MUST BE STORED IN ITS SEALED ORIGINAL CONTAINERS, IN WELL-AIRED, FRESH & DRY STOREHOUSES OR IN SHADED & POSSIBLY WELL-AIRED PLACES. IT IS RECOMMENDED THAT THE PRODUCT'S TEMP ... NOT EXCEED 25-30 °C, & KEEP ... AWAY FROM SOURCES OF HEAT, FREE FLAMES, OR SPARK-GENERATING EQUIPMENT. CONTAINERS MUST BE STACKED IN SUCH A WAY AS TO PERMIT FREE CIRCULATION OF AIR ... AT BOTTOM & INSIDE OF PILES. STORAGE AREAS MUST BE LOCATED AT SUITABLE DISTANCE FROM INHABITED BUILDINGS, ANIMAL SHELTERS, & FOOD STORES; MOREOVER, THEY MUST BE INACCESSIBLE TO UNAUTHORIZED PERSONS, CHILDREN, & DOMESTIC ANIMALS.

Rooms used for storage only should be soundly constructed & fitted with secure locks. Floors should be kept clear & pesticides clearly identified. If repacking is carried out in storage rooms, adequate light should be available; floors should be impervious & sound ... . /Pesticides/

Pesticides containers must be provided with labels indicating the degree of toxicity of the product they contain. The labels must not only give a short description of how to use the prepn, but also state basic precautions to be taken when applying it. /Organophosphorus pesticides/

Pesticides of any degree of toxicity should be transported in containers which are clearly labelled, leak-proof, and not easily damaged. They should never be transported /or stored/ beside, or above any type of food, and all spillages should be immediately reported. /Pesticides/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

All organic pesticides, whether of botanical or synthetic origin, can be destroyed by incineration. /Organic pesticides/

Manufacturers or formulators of very large amounts of pesticides may find it advantageous to build incinerators adequate to destroy all organic pesticides and equipped with scrubbers to remove acid wastes. /Organic pesticides/

In some situations where personnel may become accidently contaminated ... it is necessary to provide shower bath in addition to the usual washing facilities. Special arrangements for cleaning clothing & overalls may be necessary ... /Pesticides/

Special aircraft should preferably be used for spraying or dusting toxic organophosphorus pesticides. ... aerial spraying or dusting gives rise to clouds which spread over larger surfaces than clouds produced by ground application. Aerial spraying should therefore be carried out on windless days only. Residential areas, water supply sources, etc must be avoided. ... When aircraft approaches, signalmen /guiding the aircraft/ should leave the windward side. ... The local population should be informed about the site & time of aerial pesticide treatment. Access of unauthorized persons & especially children to the area to be treated must be ... forbidden. Warning signs should be placed at the limits of the area. Ground spraying must be carried out with compressed-air spraying equipment towed by tractors with closed cabs. /Organophosphorus pesticides/

Small packages of pesticides are preferable for individual application in order to limit the quantities to be weighed & metered. A special vessel with long stirring rod for dilution & suspension of the poison must be available in order to reduce manual handling to a minimum. The strict observance of hygiene rules--no smoking & no food intake during work. Thorough washing with soap after work, changing protective clothing before going home--is of utmost importance. /Organophosphorus pesticides/

Containers ... should be cleaned with a suspension of bleaching powder in water or with other alkaline soln after soaking for 24 hr and then be rinsed with hot water. /Organophosphorus pesticides/

For more Preventive Measures (Complete) data for IODOFENPHOS (8 total), please visit the HSDB record page.

Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure. /Phosphorus compounds/

WORKERS HANDLING AND APPLYING ORGANOPHOSPHATE PESTICIDES (OPP) MUST ... BE GIVEN PERSONAL PROTECTIVE EQUIPMENT COMPRISING OVERALLS MADE OF A TIGHT FABRIC OR POLYVINYL CHLORIDE, GLOVES, AND RUBBER BOOTS. THEY MUST WEAR A RESPIRATOR WITH AN ACTIVATED-CARBON GAS FILTER CARTRIDGE AFFORDING PROTECTION FOR A DETERMINED NUMBER OF WORKING HOURS. THE EYES SHOULD BE PROTECTED BY GOGGLES. THE SIGNALMEN FOR AERIAL DUSTING OPERATIONS SHOULD BE EQUIPPED WITH A HAT AND CAPE MADE OF POLYVINYL CHLORIDE OR A FABRIC IMPREGNATED WITH A WATER REPELLENT. /PESTICIDES, ORGANOPHOSPHORUS/

Some phenothiazines may antagonize & some may potentiate the toxic anticholinesterase effects of ... /organophosphorus insecticides/. /Organophosphate cholinesterase inhibitors/

In long term therapy, adrenocorticoids antagonize the antiglaucoma effects of anticholinesterases (incr ocular pressure). ... Anticholinergics antagonize the miotic (antiglaucoma) & other muscarinic effects of anticholinesterases on the autonomic & central nervous systems. Tricyclic antidepressants (anticholinergic effects) antagonize the antiglaucoma (miotic) effects of anticholinesterases in glaucoma. ... Antihistamines with anticholinergic effects antagonize the miotic (antiglaucoma) & CNS effects of anticholinesterases. Anticholinesterases potentiate tranquilizing & behavioral changes induced by antihistamines. The actions of anticholinesterase agents on autonomic effector cells, & to some extent those on CNS, are antagonized by atropine, an antidote of choice. Barbiturates are potentiated by anticholinesterases. ... Dexpanthenol potentiates the effects of anticholinesterases. Fluorophosphate insecticides potentiate the effects of other anticholinesterases. /Anticholinesterases/

BARBITURATES ARE POTENTIATED BY ANTICHOLINESTERASES. ALTHOUGH BARBITURATES MAY BE USED CAUTIOUSLY IN TREATING CONVULSIONS, EXTREME CARE IS ESSENTIAL IN HANDLING POISONINGS DUE TO ANTICHOLINESTERASES, PARTICULARLY ORGANOPHOSPHORUS PESTICIDES. ECHOTHIOPHATE, A CHOLINESTERASE INHIBITOR USED AS MIOTIC, POTENTIATES OTHER SUCH INHIBITORS ... USED FOR OTHER PURPOSES (ADDITIVE EFFECTS) OR POSSIBLY SYNERGISTIC. THOSE EXPOSED TO ORGANOPHOSPHATE INSECTICIDES MUST TAKE STRICT PRECAUTIONS. ... ORGANOPHOSPHORUS INSECTICIDES: ADDITIVE ANTICHOLINESTERASE EFFECTS. HAZARDOUS. PATIENTS ON ANTICHOLINESTERASES (EVEN TOPICAL, SUCH AS EYE DROPS) SHOULD AVOID AREAS WHERE ORGANOPHOSPHORUS INSECTICIDES ... RECENTLY ... USED. /ANTICHOLINESTERASE/

ANTICHOLINESTERASE (ORGANOPHOSPHORUS) INSECTICIDES ANTAGONIZE POLARIZING MUSCLE RELAXANTS. PHENOTHIAZINES /AND THIOXANTHENES/: ... MAY ENHANCE TOXIC EFFECTS OF ORGANOPHOSPHORUS INSECTICIDES. /INSECTICIDES, ORGANOPHOSPHORUS/

LC50 Rainbow trout 0.016 mg/l/96 hr @ 12 °C (95% confidence limit 0.012-0.023 mg/l, wt 0.7 g

LC50 Channel catfish 0.390 mg/l/96 hr @ 18 °C (95% confidence limit 0.300-0.490 mg/l), wt 0.8 g

LC50 Carassius auratus (goldfish) 1.00-1.33 mg/l/96 hr

LC50 BLUEGILL 0.42-0.75 MG/L/96 HR

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 24,000(SRC), determined from a measured log Kow(2) and a recommended regression-derived equation(3), suggests that iodofenphos will be immobile in soil(SRC). Iodofenphos had measured half-lives of 70.5 and 85.1 days in illuminated and non-illuminated soil, respectively(4). The main degradation product was 2,5-dichloro-4-iodophenol indicating that the main decomposition reaction was the cleavage of the aryl ester bond(4). Degradation was due to both abiotic and biotic reactions. Volatilization of iodofenphos is not expected to be important from moist soil surfaces(SRC) given an estimated Henry's Law constant of 4.5X10-6 atm-cu m/mole(SRC), determined from experimental values for vapor pressure(5) and water solubility(6). Volatilization from dry soil surfaces(SRC) is not expected based on a measured vapor pressure of 8.25X10-7 mm Hg(5).

AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 24,000(SRC), determined from a measured log Kow(2) and a recommended regression-derived equation(1), suggests that iodofenphos will adsorb to suspended solids and sediment in water(SRC). Half-lives of 0.4 and 1.9 days were measured for iodofenphos in illuminated and non-illuminated rainwater, respectively(3). The main degradation product was 2,5-dichloro-4-iodophenol indicating that the main decomposition reaction was the cleavage of the aryl ester bond(3). Degradation was due to both abiotic and biotic reactions. Iodofenphos is not expected to volatilize from water surfaces based on an estimated Henry's Law constant of 4.5X10-6 atm-cu m/mole(SRC), calculated from experimental values for vapor pressure(4) and water solubility(5). Estimated half-lives for a model river and model lake are 17 and 130, respectively(1,SRC), although adsorption to particulate matter may attenuate the volatilization of this compound from water surfaces(SRC). An estimated BCF value of 9000(1,SRC), from an estimated log Kow(2,SRC), and a BCF of 48,000, measured in guppies(6), indicate that iodofenphos will bioconcentrate in aquatic organisms(SRC), according to a recommended classification scheme(7).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), iodofenphos, which has a measured vapor pressure of 8.25X10-7 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase iodofenphos is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 7 hours(3,SRC). Particulate-phase iodofenphos may be physically removed from the air by dry deposition(SRC).

Iodofenphos applied at 0.3 mg/kg soil slightly stimulated the soil nitrifying activity while a 10 fold increase in the insecticide rate caused an inhibition of nitrification. The nitrification inhibition increased with further increase in iodofenphos rate to 6-7.5 mg/kg soil. The inhibition increased during the 1st 10 days of the insecticide application and then decreased but was still observed 30 days after iodofenphos treatment of the soil.

Photolysis of ... iodofenphos ... was studied in the dark and under artificial sunlight conditions in rain water and on standard soil surface. Iodofenphos was readily degraded under the conditions used. ... The major degrdn product identified from iodofenphos was 2,5-dichloro-4-iodophenol. ... Metabolites were found in both media in the dark and under artificial sun light.

Workers handling & applying pesticides must undergo an annual medical examination at the beginning of each agricultural season. Contraindications for work with /organophosphorus pesticides/ are organic diseases of the central nervous system, mental disorders & epilepsy, pronounced endocrine & vegetative disorders, pulmonary tuberculosis, bronchial asthma, chronic respiratory diseases, cardiovascular diseases & circulatory disorders, gastrointestinal diseases (peptic ulcer), gastroenterocolitis, diseases of liver & kidneys, eye diseases (chronic conjunctivitis & keratitis). The blood cholinesterase activity must be determined before work starts. In the event of prolonged work periods, this activity should be determined at intervals of 3-4 days. Persons exhibiting a fall in cholinesterase activity of 25% or more must be transferred to other work where they are not exposed to organophosphorus pesticides until this activity is completely restored. Persons with initial signs of indisposition should cease work with pesticides. /Organophosphorus pesticides/

A final diagnosis of mild to moderate acute organophosphate pesticide poisoning is rarely justified unless all of the following five conditions are present: 1. A definite history of exposure to an organophosphate pesticide. 2. A latent interval of not more than a few hours between that last exposure and the onset of illness. 3. A clinical picture in which most or all of the following signs or symptoms are present: headache, blurred vision, weakness, tightness in chest, and constricted pupils. 4. Reduction of plasma and RBC cholinesterase activity to a level substantially below 50% of baseline values. Because of the wide normal range of RBC cholinesterase in the population, symptoms may be present with reported "normal" levels. 5. An acute illness that is not substantially longer than 48 hours. The classic presentation for acute organophosphate toxicity includes history, evidence of exposure to organophosphate (garlic odor), signs/symptoms of cholinergic excess, improvement with atropine or pralidoxime, and inhibition of cholinesterase in blood. /Organophosphate pesticide poisoning/

... Surveillance of workers could be carried out through measurement of blood or urinary levels of the cmpd to which they are exposed, or through measurement of a metabolite. /Organic phosphorus pesticides/

The Koc of iodofenphos is estimated as approximately 24,000(SRC), using a measured log Kow of 5.51(1) and a regression-derived equation(2,SRC). According to a recommended classification scheme(3), this estimated Koc value suggests that iodofenphos will be immobile in soil(SRC).

Five sprayers and one mixer applied 50% water-wettable iodofenfos powder as a 5% suspension of active ingredient at an intended rate of 2 gm/sq m. They treated a village of 874 homes and 412 other structures. Most of the walls were of mud and the roofs of thatch. The work required 5 to 6 hr/day for 8 days. No complaints attributed to the insecticide were elicited from the 6 workers or the 1819 inhabitants of the village. There was no significant depression of whole-blood cholinesterase among the workers or among over 30 inhabitants who were tested 1 and 10 days after spraying.

All the organophosphorus insecticides have a cumulative effect by progressive inhibition of cholinesterase ... /Organophosphorus insecticides/

The symptoms of chronic poisoning due to organophosphorus pesticides include headache, weakness, feeling of heaviness in head, decline of memory, quick onset of fatigue, disturbed sleep, loss of appetite, & loss of orientation. Psychic disorders, nystagmus, trembling of the hands & other nervous system disorders can be observed in certain cases. Sometimes neuritis, paresis & paralysis develop. /Organophosphorus pesticides/

Organophosphorus cmpd can produce dermal irritation but most are weak sensitizers. /Organophosphate cmpd/

For more Human Toxicity Excerpts (Complete) data for IODOFENPHOS (18 total), please visit the HSDB record page.

Iodofenphos's former use(1) as a contact and stomach insecticide and acaricide for control of flies and mosquitoes in public hygiene, indoor pests such as ants, bedbugs, cockroaches, fleas and warehouse pests(2) has resulted in its direct release to the environment(SRC).

Iodofenphos had measured half-lives of 70.5 and 85.1 days in illuminated and non-illuminated soil, respectively(1). The main degradation product was 2,5-dichloro-4-iodophenol indicating that the main decomposition reaction was the cleavage of the aryl ester bond(1). Degradation was due to both abiotic and biotic reactions.

An estimated BCF value of 9000 was calculated for iodofenphos(SRC), using a measured log Kow of 5.51(1) and a recommended regression-derived equation(2). Guppies, Poecilia reticulata, exposed to a mixture of cyanophos, methylparathion, ronnel, fenitrothion, dicapthon, and iodofenphos had a bioconcentration factor of 48,000 for iodofenphos; an elimination rate constant of 0.36/day was observed for the same compound(3). According to a recommended classification scheme(4), these values indicate a very high BCF, and that short-term bioaccumulation will occur(SRC) based on a measured elimination rate in aquatic organisms(3).

Biotransformation of a series of organophosphorus compounds by the 9,000 g supernatant of rainbow trout (Oncorhynchus mykiss) liver was tested in an in vitro system fortified either with NADPH-generating cofactors or with reduced glutathione. Elimination rate constants for both systems were calculated from linear decay curves when substrate concentrations were used that were considerably lower than the Km values of the concerned enzymatic reactions. The results reveal a large variation in both the oxidative and the glutathione-mediated biotransformation rate of the organophosphorus compounds. Half-lives ranged from 25 to 1,216 min in the NADPH system and from 18 to 381 min in the glutathione system. Elimination rate constants in the glutathione system were related to Hammett sigma constants or reactivity toward 4-nitrobenzylpyridine, which substantiates the assumption that electrophilicity is the controlling variable for the reaction with glutathione within this particular class of compounds. A remarkable analogy was observed between compounds that were metabolized relatively quickly by glutathione S-transferases and compounds that showed a reduced bioconcentration factor in guppies. A significant improvement of the relationship between the bioconcentration factor in guppies and the octanol/water partition coefficient was obtained when the rate constant with glutathione was introduced in this relationship. Such an improvement was not obtained with the rate constants from the oxidative system. These observations are discussed in view of the differences in the activities of the involved enzyme systems in the test species and in view of the possible relevance of the different biotransformation pathways for the in vivo situation.

Cholinesterase inhibitor.

The cardiovascular actions of anticholinesterase agents are complex, since they reflect both ganglionic and postganglionic effects of accumulated ACh on the heart and blood vessels. The predominant effect on the heart from the peripheral action of accumulated ACh is bradycardia, resulting in a fall in cardiac output. Higher doses usually cause a fall in blood pressure, often as a consequence of effects of anticholinesterase agents on the medullary vasomotor centers of the CNS. /Anticholinesterase agents/

Organophosphorus derivatives act by combining with and inactivating the enzyme acetylcholinesterase. ... The inactivation of cholinesterase by cholinesterase inhibitor pesticides allows the accumulation of large amounts of acetylcholine, with resultant widespread effects that may be ... separated into 4 categories: (1) Potentiation of postganglionic parasympathetic activity. ... (2) Persistent depolarization of skeletal muscle ... (3) Initial stimulation following depression of cells of central nervous system ... (4) Variable ganglionic stimulation or blockade ... /Cholinesterase inhibitor pesticides/

The main feature of the toxic mechanism of organophosphorus pesticides is inhibition of the esterase enzyme activity, in particular of cholinesterase, which plays an important physiological part. Organophosphorus pesticides can also indirectly interact with the biochemical receptors of acetylcholine. /Organophosphorus pesticides/

For more Mechanism of Action (Complete) data for IODOFENPHOS (7 total), please visit the HSDB record page.

OVER 80% OF IODOFENPHOS ADMIN TO RAT WAS ELIMINATED IN 24 HR IN URINE. IN ADDITION TO FIVE UNIDENTIFIED METABOLITES, IODOFENOXON, DESMETHYL IODOFENOXON, MONO- & DI-METHYL PHOSPHORIC ACID, PHOSPHORIC ACID, & DIMETHYL PHOSPHOROTHIOIC ACID WERE FOUND IN URINE.

AFTER INJECTION OF IODOFENPHOS INTO TOMATO PLANTS, /ONE/ OXYGEN ANALOG WAS DETECTED IN LEAVES BUT NOT IN STEMS.

The metabolism of the organophosphorus insecticide ... iodofenphos ... in rain water was studied under artificial sunlight and in darkness. During degradation experiments several parameters (eg concentration of the water samples, temperature, time of erradiation) were strictly controlled. The polar metabolites showing an inhibition of cholinesterase were detected by a highly sensitive enzymatic inhibition method.

Treatment of an Angora goat with iodofenphos produced some 4-iodophenol in the urine only.

For more Metabolism/Metabolites (Complete) data for IODOFENPHOS (7 total), please visit the HSDB record page.

IT ... PENETRATES INTO PLANT TISSUES.

OVER 80% OF IODOFENPHOS ADMIN TO RAT WAS ELIMINATED IN 24 HR IN URINE.

Ninety-two percent of (32)P-iodofenfos was eliminated by rats within 24 hours after an oral dose. A trace of iodofenoxon was found in the urine, but over 98% of the total radioactivity in the urine was in the form of metabolites.

Most organophosphate compounds are ... absorbed from skin, conjunctiva, gastrointestinal tract, & lung. /Organophosphate compounds/

For more Absorption, Distribution and Excretion (Complete) data for IODOFENPHOS (9 total), please visit the HSDB record page.

Used as insecticide and acaricide for crops, public hygiene, homes, warehouses, and farms (especially poultry houses); [HSDB] Used as veterinary ectoparasiticide; [Merck Index]

Farming (Pesticides) [Category: Industry]

A CONTACT & STOMACH INSECTICIDE & ACARICIDE FOR CONTROL OF FLIES & MOSQUITOES (ADULTS & LARVAE) IN PUBLIC HYGIENE, INDOOR PESTS SUCH AS ANTS, BEDBUGS, COCKROACHES, FLEAS & WAREHOUSE PESTS; ALSO RECOMMENDED FOR FARM USE, ESPECIALLY IN POULTRY HOUSES AGAINST MEALWORM BEETLES, MITES & FLIES

FOR CROP PROTECTION, 500-1500 G AI/HA IS EFFECTIVE AGAINST WIDE RANGE OF COLEOPTEROUS, DIPTEROUS & LEPIDOPTEROUS PESTS, PERSISTING FOR 1-2 WEEKS.

IT GIVES PERSISTENT CONTROL OF ... GNATS & TRIALS ARE /BEING/ CONDUCTED /FOR EFFECTIVENESS FOR/ INSECTS ON ANIMALS.

Insecticide that controls flies, mosquitoes, fleas, bedbugs, beetles, moths, cockroaches, mosquito larvae, poultry mites, ticks.

... BY REACTION OF O,O-DIMETHYL PHOSPHOROCHLORIDOTHIOATE WITH SODIUM 2,5-DICHLORO-4-IODOPHENATE.

1,2,4-trichlorobenzene + O,O-dimethyl phosphorochlorothioate (ring iodination/dehydrochlorination)

'NUVANOL N' WP, WETTABLE POWDER (500 G AI/KG); 'NUVANOL N' 500 FW, SUSPENSION CONCENTRATE (500 G/L); 'NUVANOL N' 20 U, EMULSIFIABLE CONCENTRATE (200 G/L); 'NUVANOL N' 5 P READY-TO-USE POWDER (50 G/KG). PRODUCTS SOLD UNDER TRADE MARK 'ALFACRON' ARE NO LONGER AVAILABLE.

Mixed formulations: Iodofenphos + Dichlorvos.

ALFACRON

C 9491

For more Formulations/Preparations (Complete) data for IODOFENPHOS (14 total), please visit the HSDB record page.

The WHO Recommended Classification of Pesticides by Hazard identifies Iodofenphos (technical grade) as an active ingredient believed to be obsolete or discontinued for use as a pesticide.

INTRODUCED /IN 1966/ BY CIBA AG (NOW CIBA-GEIGY AG) (BELGIAN PATENT 672431; BRITISH PATENT 1057609) AS CODE NUMBER 'C9491'; TRADE MARK 'NUVANOL N'.

Miscible with other neutral, powder-formulated insecticides.

Nuvanol N is not marketed in the USA

For more General Manufacturing Information (Complete) data for IODOFENPHOS (6 total), please visit the HSDB record page.