기본 정보
- CAS
77-39-4- 표준 SMILES
OC(CCN1CCCCC1)(c1ccccc1)C1CCCC1- InChIKey
SWRUZBWLEWHWRI-UHFFFAOYSA-N- 분자식
- C19H29NO
- 평균 분자량
- 287.4 g/mol
- 단동위원소 질량
- 287.22491455
개요
Cycrimine is a member of the class of piperidines that is 3-(piperidin-1-yl)propan-1-ol in which one of the hydrogen atoms at the 1-position is substituted by cyclopentyl, and the other is substituted by phenyl. A central anticholinergic, it is used as its hydrochloride salt in the management and treatment of Parkinson's disease. It has a role as an antiparkinson drug, a muscarinic antagonist and an antidyskinesia agent. It is a member of piperidines, a tertiary alcohol and a tertiary amino compound.
이름 및 식별자
- 우선 이름
- Cycrimine
- IUPAC
- 1-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
- 영어명
- cycrimine
- 분자식
- C19H29NO
- 분자량
- 287.444
이름 및 동의어
cycrimine77-39-4CicriminaCycriminum(+-)-cycrimine1-cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-olalpha-Cyclopentyl-alpha-phenyl-1-Piperidinepropanol543567RFQQCHEBI:59692DTXSID508617691-Piperidinepropanol, alpha-cyclopentyl-alpha-phenyl-RefChem:130055
이름 더 보기
cycrimine USP/EP/BP1-Piperidinepropanol, α-cyclopentyl-α-phenyl-α-Cyclopentyl-α-phenyl-1-piperidine-1-propanol1-Phenyl-1-cyclopentyl-3-piperidino-1-propanol1-cyclopentyl-1-phenyl-3-piperidino-propan-1-ol1-cyclopentyl-1-phenyl-3-piperidin-1-yl-propan-1-ol
DTXCID50810651alpha-cyclopentyl-alpha-phenyl-1-piperidinepropanol.HCl201-024-61-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol1-Piperidinepropanol, a-cyclopentyl-a-phenyl-1-Piperidinepropanol, .alpha.-cyclopentyl-.alpha.-phenyl-.alpha.-Cyclopentyl-.alpha.-phenyl-1-piperidinepropanolCycriminum [INN-Latin]
데이터베이스 식별자
- CAS
77-39-4- PubChem CID
- 2911
- DTXSID
DTXSID50861769- ChEMBL
CHEMBL1201227- ChEBI
CHEBI:59692- UNII
- 543567RFQQ
- EC Number
- 201-024-6
- Nikkaji
- J4.201C
물성
구조 계산 물성
- XLogP
- 3.9
- 극성 표면적
- 23.5 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 21
- 형식 전하
- 0
- 복잡도
- 301
실험 및 물리화학적 성질
LogP4
Solubility9.09e-03 g/L
Melting Point112-113
Physical DescriptionSolid
물리화학적 성질
- 녹는점
- 90 · 90-92°C
- 끓는 점
- 125 · 125-135 °C(Press: 0.02 Torr)
- 밀도
- 1.057 · 1.057±0.06 g/cm3(Predicted)
- 저장 조건
- -20 °C · -20°C Freezer, Under inert atmosphere
- 용해도
- 클로로포름(약간 용해됨), 에틸아세테이트, 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 14.4 · 14.40±0.29(Predicted)
- 색상
- 황백색에서 연한 노란색
- 안정성
- Stable under recommended storage conditions., Stable Under Recommended Storage C
화학 및 산업
약리 정보
Protein Binding14-21%
Pharmacodynamics
Cycrimine is a central anticholenergic used in the treatment of the symptoms of Parkinson's disease. It is a drug used to reduce levels of acetylcholine. Acetylcholine is usually in balance with dopamine neurotransmitters, however lower levels of dopamine are present in the brain of patients suffering from Parkinson's disease. By lowering levels of acetylcholine, it is thought that this balance may be restored.
Mechanism of ActionCycrimine binds the muscarinic acetylcholine receptor M1, effectively inhibiting acetylcholine. This decrease in acetylcholine restores the normal dopamine-acetylcholine balance and relieves the symptoms of Parkinson's disease.
Cellular LocationsMembrane
응용 분야
용도Cycrimine is a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.
상·하류 제품 정보
상류 원료
공급사10 곳
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추가 설명
정의ChEBI: A member of the class of piperidines that is 3-(piperidin-1-yl)propan-1-ol in which one of the hydrogen atoms at the 1-position is substituted by cyclopentyl, and the other is substituted by phenyl. A central anticholinergic, it is used as its hydrochlorid salt in the management and treatment of Parkinson's disease.
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