Deoxynojirimycin
DNJ · Sepetaprost · DEOXYNOJIRIMYCIN · moranoline · DNM · Duvoglustat · S-GI · EIEE31
식별자 및 물리적 특성
| CAS No. | 19130-96-2 |
|---|---|
| 분자식 | C6H13NO4 |
| 평균 분자량 | 163.17 g/mol |
| 단동위원소 질량 | 163.0844579 g/mol |
| SMILES | OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O |
| InChIKey | LXBIFEVIBLOUGU-JGWLITMVSA-N |
| PubChem CID | 29435 |
| ChEMBL | CHEMBL307429 |
| ChEBI | CHEBI:44369 |
| EC No. | 606-239-2 |
| DTXSID | DTXSID70172647 |
화학 및 물리적 성질
| XLogP | -2.3 |
|---|---|
| 극성 표면적 | 93 |
| 수소 결합 공여자 수 | 5 |
| 수소 결합 수용자 수 | 5 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 11 |
| 형식 전하 | 0 |
| 복잡도 | 132 |
| 의약품 | Pharmaceuticals -> Listed in ZINC15Pharmaceuticals -> Antibiotics |
| 녹는점 | 195-196°C |
| 끓는 점 | 361.1±42.0 °C(Predicted) |
| 밀도 | 1.456±0.06 g/cm3(Predicted) |
| 증기압 | 0Pa at 25℃ |
| 저장 조건 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 용해도 | 최대 25 mg/ml의 물에 용해됩니다. |
| pKa(산도 계수) | 13.77±0.70(Predicted) |
| 물리적 상태 | 가루 |
| 색상 | 하얀색 |
| 용해도 | 물, 디메틸설폭사이드 및 메탄올에 용해됩니다. |
| BRN | 3588039 |
| 안정성 | 제공된 대로 구매일로부터 2년 동안 안정적입니다. 증류수 용액은 -20°에서 최대 3개월 동안 보관할 수 있습니다. |
| 주요 응용 | 음식 및 음료제약 |
| 화장품 원료 기능 | 피부 보호피부 컨디셔닝 - 기타 |
| InChI | 1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 |
| InChIKey | LXBIFEVIBLOUGU-JGWLITMVSA-N |
| SMILES | OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O |
| LogP(분배 계수) | -1.8 |
화학적 성질
White Crystalline Solid
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 96% (24 of 25) of all reports.Not ClassifiedAggregated GHS information provided per 25 reports by companies from 2 notifications to the ECHA C&L Inventory. |
|---|---|
| 규제 정보 | Status: Active Update: 17-10-2012 https://echa.europa.eu/registration-dossier/-/registered-dossier/81083,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-: Does not have an individual approval but may be used under an appropriate group standard |
| Hazard Classes and Categories | Not Classified |
| 수질 위해 등급(WGK) | 1 |
| 관세 코드 | 29329990 |
| 안전 문구(S) | 24/25 |
| 저장 분류 | 11 - Combustible Solids |
용도
출처
1-Deoxynojirimycin (DNJ), a product of fermentation, exists in mulberry leaves and Commelina communis (dayflower) as well as is isolated from several bacterial strains such as Bacillus and Streptomyces species. Mulberry, a common deciduous plant, belongs to the genus Morus (Moraceae family). Numerous researchers have reported the DJN contents in different parts and various varieties of mulberry. Various mulberry varieties contain DNJ contents ranging between 0.68 and 2.78 mg/gm, while this fraction varies between 1.57 and 3.48 mg/gm in different Chinese mulberry leaves. Moreover, mulberry shoots contain the highest contents of DNJ, followed by young mulberry leaves. Mature leaves of mulberry contain the least content of DNJ. All the mulberry leave groups showed a 1–2-fold increase in DNJ contents compared to unfermented mulberry leaf powder extract (UFMLE). Additionally, fermented mulberry leaf powder extract exhibited higher α-glucosidase activity than UFMLE. DNJ-rich food products can be prepared by fermenting mulberry leaves using the above-mentioned fermenting agents[6].
용도
An alpha-glucosidase inhibitor. Interferes with normal processing of N-linked glycoproteins.(+)-1-Deoxynojirimycin acts as an inhibitor of alfa-glucosidase I and II and maltase-glucoamylase. It also inhibits mammalian glucosidase, intestinal and lysosmal, beta-glucosidase from sweet almonds, pancreatic alfa-amylase and amyloglucosidase. Further, it serves as a enzyme enhancer for the treatment of Fabry and Pompe disease.