| GHS 분류 | WarningH315: Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.9% (27 of 2894) of reports.H315 (95.5%): Causes skin irritation [Warning Skin corrosion/irritation] |
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| 규제 정보 | Chemical: Decanoic acidDecanoic acid is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Decanoic acid are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)2008/127, Reg. (EU) 2017/195, Reg. (EU) 2020/1160, Reg. (EU) 2021/745 , Reg. (EU) 2023/1446, Reg. (EU) 2024/1280, Reg. (EU) 2024/2221, Reg. (EU) No 540/2011Status: Active Update: 04-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/18512Decanoic acid: Does not have an individual approval but may be used under an appropriate group standard |
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| 기타 안전 정보 | IMAP assessments - Decanoic acid: Environment tier I assessment |
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| 화재 위험 | This chemical is combustible. (NTP, 1992) |
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| 화재 가능성 | Combustible |
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| 건강 유해성 | Harmful if swallowed or inhaled. Material is irritating to tissues of mucous membranes, and upper respiratory tract, eyes and skin. (USCG, 1999) |
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| 유해성 요약 | Emergency treatment: non-toxic ingestionA skin irritantNeat material highly irritating in rabbit eyesCauses skin irritation in human volunteers in concentrations >1%[HSDB] A skin, eye, mucous membrane, and upper respiratory tract irritant[CAMEO] Safe when used as a flavoring agent in food[JECFA] An irritant[MSDSonline] |
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| FDA 요건 | Capric acid is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity of the substance added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) any substance intended for use in or on food is of appropriate food grade and is prepared and handled as a food ingredient. |
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| 반응성 그룹 | Acids, Carboxylic |
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| EPA Safer Chemical | Chemical: Decanoic acid |
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| FIFRA 요건 | Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (b) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Dairy processing equipment, and food-processing equipment and utensils. Decanoic acid is included on this list. Limit: when ready for use, the end-use concentration is not to exceed 90 ppm.An exemption from the requirement of a tolerance is established for residues of decanoic acid in or on all raw agricultural commodities and in processed commodities, when such residues result from the use of decanoic acid as an antimicrobial treatment in solutions containing a diluted end-use concentration of decanoic acid (up to 170 ppm per application) on food contact surfaces such as equipment, pipelines, tanks, vats, fillers, evaporators, pasteurizers and aseptic equipment in restaurants, food service operations, dairies, breweries, wineries, beverage and food processing plants |
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| Reactivity Profile | DECANOIC ACID reacts exothermically to neutralize bases. Can react with active metals to form gaseous hydrogen and a metal salt. May absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers. Reacts with cyanide salts or solutions of cyanide salts to generate gaseous hydrogen cyanide. Reacts exothermically with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides to generate flammable and/or toxic gases. Can react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Reacts with carbonates and bicarbonates to generate a harmless gas (carbon dioxide). Can be oxidized exothermically by strong oxidizing agents and reduced by strong reducing agentsa wide variety of products is possible. May initiate polymerization reactions or catalyze (increase the rate of) reactions among other materials. |
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| Air and Water Reactions | Insoluble in water. |
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| 소화 | Fire Extinguishing Agents Not to Be Used: Water may not be effective. |
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| 응급 처치 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
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| 보관 조건 | Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water. /Residential uses/ |
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| 정리 방법 | If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label./Residential uses/After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide..To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash. /Residential uses/ |
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| 비화재 누출 대응 | Neutralizing Agents for Acids and Caustics: Sodium bicarbonate solution (USCG, 1999) |
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| 처리 방법 | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal. /Residential uses/Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Do cut or puncture other empty pesticide containers made of metal or plastic to prevent someone from reusing them. Wrap the empty container and put it in the trash after you have rinsed it. /Residential uses/ |
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| Preventive Measures | Wear the items of protective clothing the label requires: for example, non-absorbent gloves (not leather or fabric), rubber footwear (not canvas or leather), a hat, goggles, or a dust-mist filter. If no specific clothing is listed, gloves, long-sleeved shirts and long pants, and closed shoes are recommended. You can buy protective clothing and equipment at hardware stores or building supply stores. /Residential uses/Indoor Applications. If the label directions permit, leave all windows open and fans operating after the application is completed. If the pesticide product is only effective in an unventilated (sealed) room or house, do not stay there. Put all pets outdoors, and take yourself any your family away from treated areas for at least the length of time prescribed on the label. Apply most surface sprays only to limited areas such as cracksdon't treat entire floors, walls, or ceilings. Don't let pesticides get on any surfaces that are used for food preparation. Wash any surfaces that may have pesticide residue before placing food on them. /Residential uses/Indoor Applications. When using total release foggers to control pests, use no more than the amount needed and to keep foggers away from ignition sources (ovens, stoves, air conditioners, space heaters, and water heaters, for example). Foggers should not be used in small, enclosed places such as closets and cabinets or under tables and counters. /Residential uses/Outdoor Applications. Never apply pesticides outdoors on a windy day (winds higher than 10 mph). Position yourself so that a light breeze does not blow pesticide spray or dust into your face. /Residential uses/ |
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| Allowable Tolerances | Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (b) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Dairy processing equipment, and food-processing equipment and utensils. Decanoic acid is included on this list. Limit: when ready for use, the end-use concentration is not t exceed 90 ppm.An exemption from the requirement of a tolerance is established for residues of decanoic acid in or on all raw agricultural commodities and in processed commodities, when such residues result from the use of decanoic acid as an antimicrobial treatment in solutions containing a diluted end-use concentration of decanoic acid (up to 170 ppm per application) on food contact surfaces such as equipment, pipelines, tanks, vats, fillers, evaporators, pasteurizers and aseptic equipment in restaurants, food service operations, dairies, breweries, wineries, beverage and food processing plants |
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| Personal Protective Equipment (PPE) | Respirator, chemical safety goggles, rubber boots, and heavy rubber gloves. (USCG, 1999) |
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| 체내 부담 | Samples of mother's milk were collected from Bayonne, NJJersey City, NJPittsburgh, PABaton Rouge, LAand Charleston, WV and analyzed for volatile and semivolatile organics. Decanoic acid was not detected(1). |
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| Treatment | Management of acute MCADD includes rapid correction of hypoglycemia, rehydration and treatment of the underlying infection or other stress factor. Current long-term therapy includes avoidance of fasting and a high carbohydrate low-fat diet, but it does not fully prevent the crises and the neurological alterations. (A15457) |
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| 상호 작용 | The effects of sodium caprate and sodium caprylate on transcellular permeation routes were examined in rats. The release of membrane phospholipids was significantly increased only by caprate, while protein release did not change from the control in the presence of caprate or caprylate, indicating that the extent of membrane disruption was insufficient to account for the extent of the enhanced permeation. Using brush border membrane vesicles prepared from colon, with their protein and lipid component labeled by fluorescent probes, the perturbing actions of caprate and caprylate toward the membrane were examined by fluorescence polarization. Caprate interacted with membrane protein and lipids, and caprylate mainly with protein, causing perturbation to the membrane. The release of 5(6)-carboxyfluorescein previously included in brush border membrane vesicles was increased by caprate but not by caprylate. These results suggest that caprate enhances permeability via the transcellular route through membrane perturbation. /Sodium caprate/Skin permeation rates were measured in vitro using human skin samples. 6 model cmpd of diverse physicochemical properties were dissolved in propylene glycol, and the permeation rates studied in the presence and absence of various fatty acids (including decanoic and neodecanoic acid). Both decanoic and neodecanoic acid increased the skin diffusivity of 4 of the 6 model cmpd, but only decanoic acid incr the permeation rate of propylene glycol ...The in vitro human skin permeation rate of an analgesic (buprenorphine) was incr by a factor of 3.5 by the addition of 0.5% decanoic acid.The enhancing action of decanoic acid on the intestinal absorption of phenosulfonphthalein (PSP) was studied in rats. Decanoic acid and 2 hydroxy derivatives enhanced PSP absorption to varying degreesPSP was no longer absorbed once the enhancer had been completely absorbed. Absorption enhancement correlated with the ability to sequester calcium ions.For more Interactions (Complete) data for DECANOIC ACID (7 total), please visit the HSDB record page. |
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| 건강 영향 | Octanoic (OA) and decanoic (DA) acids are the predominant metabolites accumulating in medium-chain acyl-CoA dehydrogenase (MCADE.C. 1.3.99.3) deficiency (MCADD), the most common inherited defect of fatty acid oxidation. Glycine and l-carnitine bind to these fatty acids giving rise to derivatives that also accumulate in this disorder. The clinical presentation typically occurs in early childhood but can occasionally be delayed until adulthood. The major features of the disease include hypoglycemia, vomiting, lethargy and encephalopathy after fasting, infection or other metabolic stressors. (A15457) |
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| 생태독성 수치 | LC50Species: Xenopus laevis (African clawed frog, embryo)Conditions: freshwater, renewal, pH 7.0-7.8Concentration: 24000 ug/L for 96 hr (23000-25000 ug/L) /> or =98% purity/EC50Concentration: 7500 ug/L for 96 hr (7000-9000 ug/L)Effect: increased developmental changes, general (craniofacial defects, abnormal gut coiling) /> or =98% purity/LC50 Oryzias latipes (Red Killifish) 31 mg/L/96 hr /In seawaterother conditions of bioassay not specified/LC50 Oryzias latipes (Red Killifish) 20 mg/L/96 hr /In freshwaterFor more Ecotoxicity Values (Complete) data for DECANOIC ACID (10 total), please visit the HSDB record page. |
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| 환경 거동 | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 4,000 for the free acid(SRC), determined from a log Kow of 4.09(2) and a regression-derived equation(3), indicates that undissociated decanoic acid is expected to have slight mobility in soil(SRC). The pKa of decanoic acid is 4.90(4), indicating that this compound will exist almost entirely in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of decanoic acid from moist soil surfaces is not expected to be an important fate process based upon the pKa(SRC). Decanoic acid is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 3.66X10-4 mm Hg(6). A 46% of theoretical BOD after 20 days in the presence of sewage inoculum(7) and 42% of theoretical BOD in 1 day using an activated sludge inoculum(8) suggest that biodegradation may be important environmental fate process in soil.AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 4,000 for the free acid(SRC), determined from a log Kow of 4.09(2) and a regression-derived equation(3), indicates that undissociated decanoic acid is expected to adsorb to suspended solids and sediment(SRC). A pKa of 4.90(4) indicates decanoic acid will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation of 100 ppm decanoic acid using a Japanese cultivation method was 100% in river water and 100% in sea water after 3 days(8), suggesting that biodegradtion may be an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), decanoic acid, which has a vapor pressure of 3.66X10-4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase decanoic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 1.4 days(SRC), calculated from its rate constant of 1.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). |
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| 식품 조사 수치 | Flavoring constituents of cassava (Manihot esculenta) from the Dominican Republic, gari from Nigeria, and farine from the Caribbean (St. Lucia) were analyzed. Decanoic acid was identified in gari, amounts unknown(1). The decanoic acid content in milk fat from cows ranges from 1.19 to 2.01 percent of total fatty acid content(2). Decanoic acid was identified in raw beef using supercritical carbon dioxide extraction0.10 percent of the noncondensable volatile fraction area was identified as decanoic acid(3). Decanoic acid was identified as a volatile constituent of cooked strawberry jam at a concn of 6.1 mg/kg(4). Decanoic acid has been identified in mutton and beef volatiles, concn unknown(5). The fine aerosol emission rate for decanoic acid from a frying hamburger (extralean/regular), from a charbroiled hamburger (extralean), and from a charbroiled hamburger (regular) was determined to be 3.5, 16.3, and 25.0 mg/kg, respectively(6). Decanoic acid was found as a volatile component of raw and roasted earth-almond (Cyperus esculentus L.)(7). Decanoic acid occurs as a component (along with caprylic acid and behenic acid) of caprenin, a triglyceride used as a low calorie cocoa butter substitute(8).Decanoic acid was found in gas and particulate matter effluents from commercial-scale meat charbroiling operations at 8,890 and 2,220 ug/kg meat cooked, respectively(1). |
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| 노출 경로 | Dermal (MSDS)eye contact (MSDS)inhalation (MSDS)oral (MSDS) |
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| Milk Concentrations | ENVIRONMENTAL: The decanoic acid content in milk fat from cows ranges from 1.19 to 2.01 percent of total fatty acid content(1). Decanoic acid was not detected in samples of mother's milk that were collected from Bayonne, NJJersey CityNJ, Pittsburgh, PABaton Rouge, LAand Charleston, WV and analyzed for volatile and semivolatile organics(2). |
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| 독성 요약 | The CIR Expert Panel concluded that the following ingredients are safe in the present practices of use andconcentration described in the safety assessment when formulated to be non-irritating and non-sensitizing, which may be basedon a QRA...Capric Acid...Safe for use in cosmetics, with qualificationsIt has been demonstrated that octanoic (OA) and decanoic (DA) acids compromise the glycolytic pathway and citric acid cycle functioning, increase oxygen consumption in the liver and inhibit some activities of the respiratory chain complexes and creatine kinase in rat brain (A15454, A15455). These fatty acids were also shown to induce oxidative stress in the brain (A15456). Experiments suggest that OA and DA impair brain mitochondrial energy homeostasis that could underlie at least in part the neuropathology of MCADD. (A15457) |
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| Average Daily Intake | Fatty acids are an important part of the normal daily diet of mammals, birds and invertebrates.Annual consumption is 18,833.33 lb. Individual consumption is 0.01596 mg/kg/day. |
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| 생태독성 발췌 | /OTHER TERRESTRIAL SPECIES/ Of 11 C6-22 even-numbered saturated and unsaturated fatty acids and their potassium salts tested for toxicity to balsam woolly aphid (Adelges piceae), the most effective fatty acids were capric acid (C10 saturated) and oleic acid (C18 unsaturated)./OTHER TERRESTRIAL SPECIES/ /The decanoic acid/ concn that immobilizes 95% of the nematodes (Panagrellus redivivus) within 1 hr (ED95) is 156 ppm./OTHER TERRESTRIAL SPECIES/ The toxicity of ... /decanoic acid was/ evaluated using rice bloodworm larvae (10 larvae each group). Mortality was assessed after 24 hr exposure to 1, 10, 50 mg/L ... Decanoic acid caused 100% mortality at 10 or 50 mg/Lat 1 mg/L it caused 12 to 15% mortality./OTHER TERRESTRIAL SPECIES/ The insecticidal property of ... /decanoic acid/ was examined in 2 Drosophila species (D. mojavensis and D. nigrospiracula), using 2 cacti (agria and organpipe) as food source. Triplicate groups of 50 larvae were exposed to each food source, and given 30 days to emerge into adults. Decanoic acid (0.5% and 1.0%) was lethal to all D. nigrospiracula larvae. D. mojavensis was more tolerant, with viabilities of 76% and 9.3% at 0.5% and 1.0% decanoic acid respectively. Viability was 83 to 86% in the controls.For more Ecotoxicity Excerpts (Complete) data for DECANOIC ACID (8 total), please visit the HSDB record page. |
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