기본 정보
- CAS
20123-80-2- 표준 SMILES
O=S(=O)([O-])c1cc(O)ccc1O.O=S(=O)([O-])c1cc(O)ccc1O.[Ca+2]- InChIKey
QGNBTYAQAPLTMX-UHFFFAOYSA-L- 분자식
- C12H10CaO10S2
- 평균 분자량
- 418.4 g/mol
- 단동위원소 질량
- 417.9341297
개요
A drug used to reduce hemorrhage in diabetic retinopathy.
이름 및 식별자
- 우선 이름
- Calcium Dobesilate
- IUPAC
- calcium bis(2,5-dihydroxybenzenesulfonate)
- 영어명
- Calcium dobesilate
- 분자식
- 2C6H5O5S.Ca
- 분자량
- 418.41
이름 및 동의어
CALCIUM DOBESILATE20123-80-2DexiumDobesilate calciumDoxiumDobesilate de calciumCalcii dobesilasBenzenesulfonic acid, 2,5-dihydroxy-, calcium salt (2:1)Hydroquinone calcium sulfonate205 Edobesilato de calcioCALCIUM DOXYBENSYLATE
이름 더 보기
Calciumdobesilat5-benzenesulfonatecalcium dihydroxy-2QiangbenhuangsuangaiDobesilate calcium saltCALCIUMDOBESILATECAPSULE
205-E5921X1560QDTXSID60173946calcio dobesilatoCalcium, DobesilateDobesilate, CalciumDoxium 500RefChem:54622
데이터베이스 식별자
- CAS
20123-80-2- PubChem CID
- 29963
- DTXSID
DTXSID60173946- ChEMBL
CHEMBL2106191- UNII
- 5921X1560Q
- EC Number
- 243-531-5
물성
구조 계산 물성
- 극성 표면적
- 212 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 10
- 회전 가능 결합 수
- 0
- 무거운 원자 수
- 25
- 형식 전하
- 0
- 복잡도
- 228
물리화학적 성질
- 녹는점
- 300 ° · >300° (dec)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 2 O: · H2O: 용해성15mg/mL, 투명
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- 수용성
- 2 O: · H2O: 15mg/mL, clear
- 안정성
- 흡습성
- InChI
- InChI=1S/2C6H6O5S.Ca/c2*7-4-1-2-5(8)6(3-4)12(9,10)11;/h2*1-3,7-8H,(H,9,10,11);/q;;+2/p-2
- InChIKey
- QGNBTYAQAPLTMX-UHFFFAOYSA-L
- SMILES
- S([O-])(=O)(=O)C1=CC(=CC=C1O)O.S([O-])(=O)(=O)C1C=C(C=CC=1O)O.[Ca+2]
화학적 성질
White or almost white, hygroscopic powder.
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 66.7% (2 of 3) of all reports.
Warning
H315 (33.3%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)
Aggregated GHS information provided per 3 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory InformationChemical: Benzenesulfonic acid, 2,5-dihydroxy-, calcium salt (2:1)
Other Safety InformationEvaluation - Chemicals not considered for in depth evaluation - Not commercially active in Australia
Hazard Classes and CategoriesSkin Irrit. 2 (33.3%)
안전 데이터
- wgk
- 3
- 독성
- LD50 in mice: 700 mg/kg (Esteve-Subirana)
- risk_code
- 36/37/38
- hazard_code
- Xi
- safety_code
- 26
- 위험 등급
- IRRITANT
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
ATC Code
C - Cardiovascular system
QC - Cardiovascular system
MeSH Pharmacological Classification
Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.
용도 및 제조
UsesUse (kg; approx.) in Germany (2009): >1000
응용 분야
개요Calcium dobesilate is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability to reduce capillary permeability in the body. In Switzerland the drug is sold by the pharmaceutical company OM Pharma under the trade name of Doxium in capsules containing 500 mg of active ingredient.Calcium dobesilate is indicated in states of fragility and altered capillary permeability, e.g. diabetic retinopathy, chronic venous disease and hemorrhoidal disease. In combination with lidocaine or with lidocaine and dexamethasone, the drug enters the composition of preparations for the therapy of hemorrhoidal disease. In association with potassium hydrodex-sulfate[citation needed] enters the composition of adjuvant gels in the treatment of varicose veins. The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and diabetic nephropathy.
용도Calcium dobesilate is an antioxidant that has been used to treat diabetic retinopathy, in which it slows progression of the disease during long-term oral treatment by reducing microvascular permeability, leading to improved visual acuity. It not only acts as an antioxidant but also stimulates endothelial production of nitric oxide.
Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.
관련 반응
0건
현재 필터 조건에 해당하는 반응 기록이 없습니다.
화합물 노트
불러오는 중…