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기본 정보
- CAS
6990-06-3- 표준 SMILES
CC(=O)O[C@H]1C[C@@]2(C)[C@@H](C[C@@H](O)[C@H]3[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@@H]4CC[C@@]32C)/C1=C(\CCC=C(C)C)C(=O)O- InChIKey
IECPWNUMDGFDKC-MZJAQBGESA-N- 분자식
- C31H48O6
- 평균 분자량
- 516.719 g/mol
- 단동위원소 질량
- 516.34508926
이름 및 식별자
- 우선 이름
- Fusidic acid
- IUPAC
- (17Z)-16beta-(Acetyloxy)-3alpha,11alpha-dihydroxy-4alpha,8,14-trimethyl-5alpha,8alpha,9beta,13alpha,14beta-18-norcholesta-17,24-dien-21-oic acid
- 영어명
- Fusidic Acid
- 분자식
- C31H48O6
- 분자량
- 516.71
이름 및 동의어
FUSIDIC ACIDFusidineFusidinic acid(Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-Acetoxy-3,11-dihydroxy-4,8,10,14-tetramethyldodecahydro-1H-cyclopenta[a]phenanthren-17(2H,10H,14H)-ylidene)-6-methylhept-5-enoic acidFusidic acid CRS29-NordaMMara-17(20),24-dien-21-oicacid, 16-(acetyloxy)-3,11-dihydroxy-, (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-(3ALPHA,4ALPHA,8ALPHA,9BETA,11ALPHA,13ALPHA,14BETA,16BETA,17Z)-16-(ACETYLOXY)-3,11-DIHYDROXY-29-NORDAMMARA-17(20),24-DIEN-21-OIC ACIDsq16603ramycinFuzidin
데이터베이스 식별자
- CAS
6990-06-3- PubChem CID
- 3000226
- DTXSID
DTXSID0023086- ChEMBL
CHEMBL374975- ChEBI
CHEBI:29013- UNII
- 59XE10C19C
- EC Number
- 230-256-0
- Nikkaji
- J16.166G
물성
물리화학적 성질
- 녹는점
- 190 · 190-192°C
- 끓는 점
- 521.49 °C · 521.49°C (rough estimate)
- 밀도
- 1.0389 · 1.0389 (rough estimate)
- 증기압
- 0 · 0-0Pa at 25℃
- 굴절률
- 1.489 · 1.4890 (estimate)
- 저장 조건
- 2 · Sealed in dry,2-8°C
- 용해도
- 물에는 거의 녹지 않으며, 에탄올에는 잘 녹습니다(96%).
- 산도 계수 (pKa)
- 5.35 in · pK: 5.35 in water
- 물리적 상태
- Solid
- 색상
- 흰색에서 황백색까지
- 수용성
- 2.376 · 2.376-525000μg/L at 25℃
- Merck
- 14 · 14,4317
- 안정성
- 흡습성
- 주요 응용
- 의약품(소분자)
- InChIKey
- IECPWNUMDGFDKC-MZJAQBGESA-N
- SMILES
- [H][C@@]12CC[C@@]3(C)[C@@]([H])([C@H](O)C[C@@]4([H])\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C(O)=O)[C@@]1(C)CC[C@@H](O)[C@H]2C
- LogP
- 2.68 · 2.68-6.75 at 20℃
화학적 성질
White Solid
안전 및 규제
안전 데이터
- wgk
- 3
- rtecs
- RC1350000
- 독성
- LD50 in mice (g/kg): 1.2 s.c.; 1.5 orally (Godtfredsen)
- HS 번호
- 29419000
- risk_code
- 22
- hazard_code
- Xn
- safety_code
- 36
- Hazard Classifications
- Acute Tox. 4 Oral
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
개요Fusidic Acid: An Inhibitor of the Elongation Factor G (EF-G)Fusidic acid is a steroidal antibiotic compound derived from the fungus Fusidium coccineum. The elongation factor G (EF-G) catalyzes the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation. Fusidic acid binds to EF-G, preventing its release from the ribosome, thus stalling bacterial protein synthesis. Fusidic acid is mainly notable for its activity against staphylococci, whether or not they are resistant to methicillin and related penicillins. Fusidic acid was found in the culture broth of a fungus imperfectus, Fusidium coccineum, by Leo in 1962. It has a steroid structure but shows no hormonal activity.
제조 방법
Fusidic acid (FA) is a tetracyclic triterpenoids isolated from fungi, which was first isolated from Fusidium coccineum in 1960 [1].
공급사100 곳
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추가 설명
정의ChEBI: A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.
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